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Cited by 300

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy

Open access
Oudit, Gavin Y., Liu, George C., Zhong, JiuChang, Basu, Ratnadeep, Chow, Fung L., Zhou, Joyce, Loibner, Hans, Janzek, Evelyne, Schuster, Manfred, Penninger, Josef M., Herzenberg, Andrew M., Kassiri, Zamaneh, Scholey, James W.·2010·Diabetes
DOI 10.2337/db09-1218
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Abstract

OBJECTIVE: Diabetic nephropathy is one of the most common causes of end-stage renal failure. Inhibition of ACE2 function accelerates diabetic kidney injury, whereas renal ACE2 is downregulated in diabetic nephropathy. We examined the ability of human recombinant ACE2 (hrACE2) to slow the progression of diabetic kidney injury. RESEARCH DESIGN AND METHODS: Male 12-week-old diabetic Akita mice (Ins2WT/C96Y) and control C57BL/6J mice (Ins2WT/WT) were injected daily with placebo or with rhACE2 (2 mg/kg, i.p.) for 4 weeks. Albumin excretion, gene expression, histomorphometry, NADPH oxidase activity, and peptide levels were examined. The effect of hrACE2 on high glucose and angiotensin II (ANG II)–induced changes was also examined in cultured mesangial cells. RESULTS: Treatment with hrACE2 increased plasma ACE2 activity, normalized blood pressure, and reduced the urinary albumin excretion in Akita Ins2WT/C96Y mice in association with a decreased glomerular mesangial matrix expansion and normalization of increased α-smooth muscle actin and collagen III expression. Human recombinant ACE2 increased ANG 1–7 levels, lowered ANG II levels, and reduced NADPH oxidase activity. mRNA levels for p47phox and NOX2 and protein levels for protein kinase Cα (PKCα) and PKCβ1 were also normalized by treatment with hrACE2. In vitro, hrACE2 attenuated both high glucose and ANG II–induced oxidative stress and NADPH oxidase activity. CONCLUSIONS: Treatment with hrACE2 attenuates diabetic kidney injury in the Akita mouse in association with a reduction in blood pressure and a decrease in NADPH oxidase activity. In vitro studies show that the protective effect of hrACE2 is due to reduction in ANG II and an increase in ANG 1–7 signaling.

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Metadata

Authors
Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, J. M., Herzenberg, A. M., Kassiri, Z., & Scholey, J. W.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2009-11-23
Volume
59
Issue
2
Pages
529-538
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db09-1218
OpenAlex
W2053710318
Cited by
300
References
44
FWCI
14.84
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy. https://app.cochat.ai/papers/10.2337/db09-1218
The paper
Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, J. M., Herzenberg, A. M., Kassiri, Z., & Scholey, J. W. (2010). Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy. Diabetes. https://doi.org/10.2337/db09-1218

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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