New approaches in the treatment of hypertension

Oparil, Suzanne; Schmieder, Roland E.

doi:10.1161/circresaha.116.303603

Cited by 277Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesHormonal Regulation and Hypertension

New approaches in the treatment of hypertension

Oparil, Suzanne, Schmieder, Roland E.·2015·Circulation Research

DOI 10.1161/circresaha.116.303603

Open this paper in CoChat — free account

Abstract

Hypertension is the most common modifiable risk factor for cardiovascular disease and death, and lowering blood pressure with antihypertensive drugs reduces target organ damage and prevents cardiovascular disease outcomes. Despite a plethora of available treatment options, a substantial portion of the hypertensive population has uncontrolled blood pressure. The unmet need of controlling blood pressure in this population may be addressed, in part, by developing new drugs and devices/procedures to treat hypertension and its comorbidities. In this Compendium Review, we discuss new drugs and interventional treatments that are undergoing preclinical or clinical testing for hypertension treatment. New drug classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agonists of natriuretic peptide A and vasoactive intestinal peptide receptor 2, and a novel mineralocorticoid receptor antagonist are in phase II/III of development, while inhibitors of aminopeptidase A, dopamine β-hydroxylase, and the intestinal Na(+)/H(+) exchanger 3, agonists of components of the angiotensin-converting enzyme 2/angiotensin(1-7)/Mas receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or preclinical development. The two main interventional approaches, transcatheter renal denervation and baroreflex activation therapy, are used in clinical practice for severe treatment resistant hypertension in some countries. Renal denervation is also being evaluated for treatment of various comorbidities, eg, chronic heart failure, cardiac arrhythmias and chronic renal failure. Novel interventional approaches in early development include carotid body ablation and arteriovenous fistula placement. Importantly, none of these novel drug or device treatments has been shown to prevent cardiovascular disease outcomes or death in hypertensive patients.

Integrity signals

Registry

Crossref · 10.1161/circresaha.116.303603

Cites

212 of 212 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Elevated blood pressure is an excellent clinical sign in many cardiovascular diseases, but by itself it does not provide information regarding mechanisms of any given disorder.
“However, despite blood pressure’s association with many unique dis- eases, by itself it does not provide information regarding the mechanisms of any given disorder.”
From Methods and challenges for assessing heterogeneity (2020) · cites this paper as [42]

2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214 · see citing works
2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950 · see citing works
Angiotensin-neprilysin inhibition versus enalapril in heart failure
McMurray, J. J. V., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409077 · Cited by 6,957 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
Endarterectomy for Asymptomatic Carotid Artery Stenosis
WALKER, M. D. (1995) · JAMA · doi:10.1001/jama.1995.03520420037035 · Cited by 4,435 · see citing works
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927 · see citing works
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
(2010) · The Lancet · doi:10.1016/s0140-6736(10)62039-9 · Cited by 2,242 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,232 · see citing works
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186 · see citing works
Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
Krum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
The North American Symptomatic Carotid Endarterectomy Trial
Ferguson, G. G., Eliasziw, M., Barr, H. W. K., Clagett, G. P., Barnes, R. W., Wallace, M. C., Taylor, D. W., Haynes, R. B., Finan, J. W., Hachinski, V., et al. (1999) · Stroke · doi:10.1161/01.str.30.9.1751 · Cited by 1,498 · see citing works
Neural control of renal function
DiBona, G. F., & Kopp, U. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.1.75 · Cited by 1,212 · see citing works
Revascularization versus Medical Therapy for Renal-Artery Stenosis
The ASTRAL Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905368 · Cited by 1,194 · see citing works
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial
Solomon, S. D., Zile, M. R., Pieske, B. M., Voors, A. A., Shah, A. M., Kraigher‐Krainer, E., Shi, V. C., Bransford, T. L., Takeuchi, M., Gong, J., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61227-6 · Cited by 1,171 · see citing works
Neural Control of Renal Function*
Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126 · see citing works
Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
Cooper, C. J., Murphy, T. P., Cutlip, D. E., Jamerson, K., Henrich, W. L., Reid, D., Cohen, D. J., Matsumoto, A. H., Steffes, M. W., Jaff, M. R., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310753 · Cited by 1,009 · see citing works
Clinical Practice Guidelines for the Management of Hypertension in the Community: A Statement by the American Society of Hypertension and the International Society of Hypertension
Weber, M. A., Schiffrin, E. L., White, W. B., Mann, S., Lindholm, L. H., Kenerson, J. G., Flack, J. M., Carter, B. L., Materson, B. J., Ram, C. V. S., et al. (2014) · The Journal of Clinical Hypertension · doi:10.1111/jch.12237 · Cited by 986 · see citing works
Use of Doppler Ultrasonography to Predict the Outcome of Therapy for Renal-Artery Stenosis
Radermacher, J., Chavan, A., Bleck, J. S., Vitzthum, A., Stoess, B., Gebel, M., Galanski, M., Koch, K. M., & Haller, H. G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440603 · Cited by 763 · see citing works
Prevalence of Resistant Hypertension in the United States, 2003–2008
Persell, S. D. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.170308 · Cited by 761 · see citing works
Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function
Bax, L., Woittiez, A.-J. J., Kouwenberg, H. J., Mali, W. P. T. M., Buskens, E., Beek, F. J. A., Braam, B. G., Huysmans, F. T. M., Kool, L. J. S., Rutten, M. J. C. M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00119 · Cited by 699 · see citing works
Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover.
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642 · see citing works
Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension
Chapman, N., Dobson, J., Wilson, S. L., Dahlöf, B., Sever, P., Wedel, H., & Poulter, N. R. (2007) · Hypertension · doi:10.1161/01.hyp.0000259805.18468.8c · Cited by 630 · see citing works
Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study
Krum, H., Schlaich, M. P., Sobotka, P. A., Böhm, M., Mahfoud, F., Rocha‐Singh, K. J., Katholi, R. E., & Esler, M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62192-3 · Cited by 622 · see citing works
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
Imig, J. D., & Hammock, B. D. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2875 · Cited by 616 · see citing works
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial
Pitt, B., Køber, L., Ponikowski, P. P., Gheorghiade, M., Filippatos, G. S., Krum, H., Nowack, C., Kolkhof, P., Kim, S. Y., & Zannad, F. M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht187 · Cited by 603 · see citing works
Baroreflex Activation Therapy Lowers Blood Pressure in Patients With Resistant Hypertension
Bisognano, J. D., Bakris, G., Nadim, M. K., Sanchez, L., Kroon, A. A., Schafer, J., de Leeuw, P. W., & Sica, D. A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.008 · Cited by 600 · see citing works
Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
Ruilope, L. M., Dukát, A., Böhm, M., Lacourcière, Y., Gong, J., & Lefkowitz, M. P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61966-8 · Cited by 598 · see citing works
Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial
Kostis, J. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.09.014 · Cited by 579 · see citing works
Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension
Mahfoud, F., Schlaich, M. P., Kindermann, I., Ukena, C., Cremers, B., Brandt, M. C., Hoppe, U. C., Vonend, O., Rump, L. C., Sobotka, P. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.991869 · Cited by 572 · see citing works
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
Kandzari, D. E., Bhatt, D. L., Brar, S. K., Devireddy, C. M., Esler, M., Fahy, M. P., Flack, J. M., Katzen, B. T., Lea, J. P., Lee, D. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu441 · Cited by 546 · see citing works
Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial
Azizi, M., Sapoval, M., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Midulla, M., Mounier-Véhier, C., Courand, P.-Y., Lantelme, P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61942-5 · Cited by 519 · see citing works
Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual‐Acting Angiotensin Receptor—Neprilysin Inhibitor (ARNi)
Gu, J., Noè, A., Chandra, P., Al‐Fayoumi, S., Ligueros‐Saylan, M., Sarangapani, R., Maahs, S., Ksander, G. M., Rigel, D. F., Jeng, A. Y., et al. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009343932 · Cited by 505 · see citing works
Efficacy of low-dose spironolactone in subjects with resistant hypertension
Nishizaka, M. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)01032-x · Cited by 500 · see citing works
Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension
Brandt, M. C., Mahfoud, F., Reda, S., Schirmer, S. H., Erdmann, E., Böhm, M., & Hoppe, U. C. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.034 · Cited by 498 · see citing works
EPOXIDE HYDROLASES: Mechanisms, Inhibitor Designs, and Biological Roles
Morisseau, C. H. P., & Hammock, B. D. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095920 · Cited by 482 · see citing works
Resistant hypertension? Assessment of adherence by toxicological urine analysis
Jung, O., Gechter, J. L., Wunder, C., Paulke, A., Bartel, C., Geiger, H., & Toennes, S. W. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835e2286 · Cited by 474 · see citing works
Validation of a Brachial Cuff-Based Method for Estimating Central Systolic Blood Pressure
Weber, T., Wassertheurer, S., Rammer, M., Maurer, E., Hametner, B., Mayer, C. C., Kropf, J., & Eber, B. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.176313 · Cited by 462 · see citing works
Dual Angiotensin Receptor and Neprilysin Inhibition as an Alternative to Angiotensin-Converting Enzyme Inhibition in Patients with Chronic Systolic Heart Failure: Rationale for and Design of the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure Trial (PARADIGM-HF)
McMurray, J. J. V., Packer, M., Desai, A. S., Gong, J., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K. B., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft052 · Cited by 458 · see citing works
Discovery and Characterization of Alamandine
Lautner, R. Q., Villela, D. C., Fraga-Silva, R. A., Silva, N., Verano‐Braga, T., Costa-Fraga, F. P., Jankowski, J., Jankowski, V., Sousa, F. B. D., Alzamora, A. C., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301077 · Cited by 440 · see citing works
Carotid Baroreceptor Stimulation, Sympathetic Activity, Baroreflex Function, and Blood Pressure in Hypertensive Patients
Heusser, K., Tank, J., Engeli, S., Diedrich, A., Menne, J., Eckert, S., Peters, T., Sweep, F. C. G. J., Haller, H., Pichlmaier, A. M., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140665 · Cited by 433 · see citing works
Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury
Kolkhof, P., Delbeck, M., Kretschmer, A., Steinke, W., Hartmann, E., Bärfacker, L., Eitner, F., Albrecht-Küpper, B., & Schäfer, S. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000091 · Cited by 430 · see citing works
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
Jiang, F., Yang, J., Zhang, Y., Dong, M., Wang, S., Zhang, Q., Liu, F., Zhang, K., & Zhang, C. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.59 · Cited by 427 · see citing works
High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis
Tomaszewski, M., White, C., Patel, P., Masca, N., Damani, R., Hepworth, J., Samani, N. J., Gupta, P., Madira, W., Stanley, A., et al. (2014) · Heart · doi:10.1136/heartjnl-2013-305063 · Cited by 404 · see citing works
Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
Haschke, M., Schuster, M., Poglitsch, M., Loibner, H., Salzberg, M. O., Bruggisser, M., Penninger, J. M., & Krähenbühl, S. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0072-7 · Cited by 362 · see citing works
Renal Denervation in Moderate to Severe CKD
Hering, D., Mahfoud, F., Walton, A. S., Krum, H., Lambert, G. W., Lambert, E. A., Sobotka, P. A., Böhm, M., Cremers, B., Esler, M. D., et al. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011111062 · Cited by 361 · see citing works
Novel Baroreflex Activation Therapy in Resistant Hypertension
Scheffers, I. J. M., Kroon, A. A., Schmidli, J., Jordan, J., Tordoir, J. H. M., Mohaupt, M. G., Luft, F. C., Haller, H. G., Menne, J., Engeli, S., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.089 · Cited by 356 · see citing works
Angiotensin Synthesis in the Brain and Increased Turnover in Hypertensive Rats
Ganten, D., Hermann, K., Bayer, C., Unger, T., & Lang, R. E. (1983) · Science · doi:10.1126/science.6879184 · Cited by 323 · see citing works
Effects of Aldosterone on the Vasculature
Schiffrin, E. L. (2006) · Hypertension · doi:10.1161/01.hyp.0000201443.63240.a7 · Cited by 299 · see citing works
Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy
Oudit, G. Y., Liu, G. C., Zhong, J., Basu, R., Chow, F. L., Zhou, J., Loibner, H., Janzek, E., Schuster, M., Penninger, J. M., et al. (2009) · Diabetes · doi:10.2337/db09-1218 · Cited by 298 · see citing works
Vasopeptidase Inhibitors
Corti, R., Burnett, J. C. J., Rouleau, J. L., Ruschitzka, F. T., & Lüscher, T. F. (2001) · Circulation · doi:10.1161/hc4001.097191 · Cited by 297 · see citing works
Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial
Hoppe, U. C., Brandt, M. C., Wachter, R., Beige, J., Rump, L. C., Kroon, A. A., Cates, A. W., Lovett, E. G., & Haller, H. G. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.04.004 · Cited by 289 · see citing works
Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study
Tissot, A. C., Maurer, P., Nussberger, J., Sabat, R., Pfister, T., Ignatenko, S., Volk, H., STOCKER, H., Müller, P., Jennings, G. T., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60381-5 · Cited by 287 · see citing works
Prolonged Activation of the Baroreflex Produces Sustained Hypotension
Lohmeier, T. E., Irwin, E. D., Rossing, M. A., Serdar, D. J., & Kieval, R. S. (2004) · Hypertension · doi:10.1161/01.hyp.0000111837.73693.9b · Cited by 283 · see citing works
Vasoactive intestinal peptide: cardiovascular effects
Henning, R. J. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00229-7 · Cited by 280 · see citing works
Assessment of Renal Artery Stenosis Severity by Pressure Gradient Measurements
Bruyne, B. D., Manoharan, G., Pijls, N. H. J., Verhamme, K. M. C., Maďarič, J., Bartúnek, J., Vanderheyden, M., & Heyndrickx, G. R. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.074 · Cited by 275 · see citing works
Discovery of BAY 94‐8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases
Bärfacker, L., Kühl, A., Hillisch, A., Grosser, R., Figueroa‐Pérez, S., Heckroth, H., Nitsche, A., Ergüden, J., Gielen‐Haertwig, H., Schlemmer, K., et al. (2012) · ChemMedChem · doi:10.1002/cmdc.201200081 · Cited by 273 · see citing works
Efficacy of Revascularization For Renal Artery Stenosis Caused by Fibromuscular Dysplasia
Trinquart, L., Mounier‐Véhier, C., Sapoval, M. R., Gagnon, N., & Plouin, P. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.152918 · Cited by 262 · see citing works
Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial
Esler, M., Böhm, M., Sievert, H., Rump, C., Schmieder, R. E., Krum, H., Mahfoud, F., & Schlaich, M. P. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu209 · Cited by 260 · see citing works
Antiandrogenic Effect of Spirolactones: Mechanism of Action
Corvol, P. L., Michaud, A., Ménard, J., FREIFELD, M., & MAHOUDEAU, J. A. (1975) · Endocrinology · doi:10.1210/endo-97-1-52 · Cited by 259 · see citing works
Renal Resistance Index and Progression of Renal Disease
Radermacher, J., Ellis, S., & Haller, H. G. (2002) · Hypertension · doi:10.1161/hy0202.103782 · Cited by 259 · see citing works
Ambulatory Blood Pressure Changes After Renal Sympathetic Denervation in Patients With Resistant Hypertension
Mahfoud, F., Ukena, C., Schmieder, R. E., Cremers, B., Rump, L. C., Vonend, O., Weil, J., Schmidt, M. U., Hoppe, U. C., Zeller, T., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000949 · Cited by 249 · see citing works
Baroreflex Activation Therapy provides durable benefit in patients with resistant hypertension: results of long-term follow-up in the Rheos Pivotal Trial
Bakris, G. L., Nadim, M. K., Haller, H. G., Lovett, E. G., Schafer, J. E., & Bisognano, J. D. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.01.003 · Cited by 246 · see citing works
Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension
Ferreira, A. J., Shenoy, V., Yamazato, Y., Sriramula, S., Francis, J., Yuan, L., Castellano, R. K., Ostrov, D. A., Oh, S. P., Katovich, M. J., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1678oc · Cited by 245 · see citing works
Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.
Kawamoto, T., Mitsuuchi, Y., Toda, K., Yokoyama, Y., Miyahara, K., Miura, S., Ohnishi, T., Ichikawa, Y., Nakao, K., & Imura, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1458 · Cited by 245 · see citing works
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
Xu, D., Li, N., He, Y., Timofeyev, V., Lü, L., Tsai, H.-J., Kim, I.-H., Tuteja, D., Mateo, R. K. P., Singapuri, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609158103 · Cited by 235 · see citing works
Efficacy and Safety of LCZ696, a First-in-Class Angiotensin Receptor Neprilysin Inhibitor, in Asian Patients With Hypertension
Kario, K., Sun, N., Chiang, F., Supasyndh, O., Baek, S. H., Inubushi-Molessa, A., Zhang, Y., Gotou, H., Lefkowitz, M. P., & Zhang, J. Y. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02002 · Cited by 232 · see citing works
Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial
Calhoun, D. A., White, W. B., Krum, H., Guo, W., Bermann, G., Trapani, A., Lefkowitz, M. P., & Ménard, J. (2011) · Circulation · doi:10.1161/circulationaha.111.029892 · Cited by 227 · see citing works
A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity
Ambühl, P. M., Tissot, A. C., Fulurija, A., Maurer, P., Nussberger, J., Sabat, R., Nief, V., Schellekens, C., Sladko, K., Roubicek, K., et al. (2006) · Journal of Hypertension · doi:10.1097/hjh.0b013e32800ff5d6 · Cited by 220 · see citing works
Functional role of renal afferents.
Stella, A., & Zanchetti, A. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.3.659 · Cited by 217 · see citing works
Characteristics of Resistant Hypertension in a Large, Ethnically Diverse Hypertension Population of an Integrated Health System
Sim, J. J., Bhandari, S. K., Shi, J., Liu, I. L. A., Calhoun, D. A., McGlynn, E. A., Kalantar-Zadeh, K., & Jacobsen, S. J. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.017 · Cited by 206 · see citing works
Aldosterone Synthase Inhibition With LCI699
Amar, L., Azizi, M., Ménard, J., Peyrard, S., Watson, C. E., & Plouin, P. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.157271 · Cited by 204 · see citing works
Renal nerves in the pathogenesis of hypertension in experimental animals and humans
Katholi, R. E. (1983) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1983.245.1.f1 · Cited by 197 · see citing works
Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma
Jankowski, V., Vanholder, R. C., van der Giet, M., Tölle, M., Karadogan, S., Gobom, J., Furkert, J., Oksche, A., Krause, E., Tran, T. N. A., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000253889.09765.5f · Cited by 197 · see citing works
Randomized Comparison of Renal Denervation Versus Intensified Pharmacotherapy Including Spironolactone in True-Resistant Hypertension
Rosa, J., Widimský, P., Toušek, P., Petrák, O., Čurila, K., Waldauf, P., Bednář, F., Zelinka, T., Holaj, R., Štrauch, B., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04019 · Cited by 196 · see citing works
European consensus on the diagnosis and management of fibromuscular dysplasia
Persu, A., Giavarini, A., Touzé, E., Januszewicz, A., Sapoval, M. R., Azizi, M., Barral, X., Jeunemaı̂tre, X., Morganti, A., Plouin, P., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000213 · Cited by 196 · see citing works
A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule
Fagart, J., Hillisch, A., Huyet, J., Bärfacker, L., Fay, M., Pleiß, U., Pook, E., Schäfer, S., Rafestin-Oblin, M. E., & Kolkhof, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.131342 · Cited by 192 · see citing works
The evolution of aldosterone antagonists
Garthwaite, S. M., & McMahon, E. G. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.005 · Cited by 189 · see citing works
Refractory Hypertension
Calhoun, D. A., Booth, J. N., Oparil, S., Irvin, M. R., Shimbo, D., Lackland, D. T., Howard, G., Safford, M. M., & Muntner, P. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02026 · Cited by 186 · see citing works
Therapeutic Drug Monitoring Facilitates Blood Pressure Control in Resistant Hypertension
Brinker, S. K., Pandey, A., Ayers, C., Price, A. L., Raheja, P., Arbique, D., Das, S. R., Halm, E., Kaplan, N., & Vongpatanasin, W. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.067 · Cited by 181 · see citing works
Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial
Lobo, M. D., Sobotka, P. A., Stanton, A. V., Cockcroft, J., Sulke, N., Dolan, E., van der Giet, M., Hoyer, J. D., FURNISS, S. S., Foran, J. P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)62053-5 · Cited by 179 · see citing works
Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension
Trzebski, A., Tafil, M., Zółtowski, M., & Przybylski, J. (1982) · Cardiovascular Research · doi:10.1093/cvr/16.3.163 · Cited by 177 · see citing works
Candoxatril, a neutral endopeptidase inhibitor
Bevan, E. G., Connell, J., Doyle, J., Carmichael, H. A., Davies, D. L., Lorimer, A. R., & Mclnnes, G. T. (1992) · Journal of Hypertension · doi:10.1097/00004872-199207000-00002 · Cited by 173 · see citing works
Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy
Ceral, J., Habrdová, V., Voříšek, V., Bima, M., Pelouch, R., & Solař, M. (2010) · Hypertension Research · doi:10.1038/hr.2010.183 · Cited by 170 · see citing works
Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series
Brinkmann, J., Heusser, K., Schmidt, B. M., Menne, J., Klein, G., Bauersachs, J., Haller, H., Sweep, F. C., Diedrich, A., Jordan, J., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201186 · Cited by 166 · see citing works
Multitarget Stool DNA Testing for Colorectal-Cancer Screening
Brenner, H., Werner, S., & Chen, H. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1405215 · Cited by 164 · see citing works
Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis
Štrauch, B., Petrák, O., Zelinka, T., Rosa, J., Krátká, Z., Indra, T., Chytil, L., Marešová, V., Kurcová, I., Holaj, R., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283652c61 · Cited by 163 · see citing works
Intestinal Inhibition of the Na + /H + Exchanger 3 Prevents Cardiorenal Damage in Rats and Inhibits Na + Uptake in Humans
Spencer, A. G., Labonté, E. D., Rosenbaum, D. P., Plato, C. F., Carreras, C. W., Leadbetter, M. R., Kozuka, K., Kohler, J. N., Koo-McCoy, S., He, L., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007790 · Cited by 158 · see citing works
Effects of Renal Sympathetic Denervation on Arterial Stiffness and Central Hemodynamics in Patients With Resistant Hypertension
Brandt, M. C., Reda, S., Mahfoud, F., Lenski, M., Böhm, M., & Hoppe, U. C. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.959 · Cited by 154 · see citing works
Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics
Kolkhof, P., & Borden, S. A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.025 · Cited by 152 · see citing works
Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog
Kluskens, L., Nelemans, S. A., Rink, R., de Vries, L., Meter-Arkema, A. H., Wang, Y., Walther, T., Kuipers, A., Moll, G. N., & Haas, M. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.146431 · Cited by 150 · see citing works
Blood pressure changes after renal denervation at 10 European expert centers
Persu, A., Jin, Y., Azizi, M., Baelen, M., Völz, S., Elvan, A., Severino, F., Rosa, J., Adıyaman, A., Elmula, F. E. M. F., et al. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.88 · Cited by 150 · see citing works
Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single‐ and Multiple‐Dose Studies in Healthy Human Subjects
Chen, D., Whitcomb, R., MacIntyre, E. D., Tran, V., Do, Z. N., Sabry, J. H., Patel, D. V., Anandan, S., Gless, R. D., & Webb, H. K. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010397049 · Cited by 149 · see citing works
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II
Richards, M., Wittert, G., Crozier, I., Espiner, E. A., Yandle, T. G., Ikram, H., & Frampton, C. M. (1993) · Journal of Hypertension · doi:10.1097/00004872-199304000-00011 · Cited by 145 · see citing works
Renin–Angiotensin Blockade Combined With Natriuretic Peptide System Augmentation
von Lueder, T. G., Sangaralingham, S. J., Wang, B. H., Kompa, A. R., Atar, D., Burnett, J. C. J., & Krum, H. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.000289 · Cited by 130 · see citing works
A Number of Marketed Dihydropyridine Calcium Channel Blockers Have Mineralocorticoid Receptor Antagonist Activity
Dietz, J. D., Du, S., Bolten, C. W., Payne, M., Xia, C., Blinn, J. R., Funder, J. W., & Hu, X. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103580 · Cited by 126 · see citing works
Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2
Kulemina, L. V., & Ostrov, D. A. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111413919 · Cited by 122 · see citing works
Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension
Siński, M., Lewandowski, J., Przybylski, J., Bidiuk, J., Abramczyk, P., Ciarka, A., & Gaciong, Z. A. (2011) · Hypertension Research · doi:10.1038/hr.2011.209 · Cited by 121 · see citing works
VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins
Couvineau, A., & Laburthe, M. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01676.x · Cited by 120 · see citing works
Neurogenic Hypertension
Jannetta, P. J., Segal, R., Wolfson, S. K., Dujovny, M., SEMBA, A., & Cook, E. E. (1985) · Annals of Surgery · doi:10.1097/00000658-198508000-00018 · Cited by 119 · see citing works
Posterior fossa neurovascular anomalies in essential hypertension
Naraghi, R., Huk, W. J., Fahlbusch, R., Geiger, H., Crnac, J., Luft, F. C., & Engels, G. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90289-5 · Cited by 118 · see citing works
Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
Brown, M. J., Coltart, J., Gunewardena, K. A., Ritter, J. M., Auton, T. R., & Glover, J. F. (2004) · Clinical Science · doi:10.1042/cs20030381 · Cited by 118 · see citing works
Prolonged Activation of the Baroreflex Abolishes Obesity-Induced Hypertension
Lohmeier, T. E., Dwyer, T. M., Irwin, E. D., Rossing, M. A., & Kieval, R. S. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087874 · Cited by 118 · see citing works
Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR
Tan, Z., Lu, Y., Whiteis, C. A., Simms, A. E., Paton, J. F. R., Chapleau, M. W., & Abboud, F. M. (2009) · Circulation Research · doi:10.1161/circresaha.109.206946 · Cited by 117 · see citing works
Surgical Removal of the Carotid Body for Bronchial Asthma
Nakayama, K. (1961) · Diseases of the Chest · doi:10.1378/chest.40.6.595 · Cited by 117 · see citing works
Phase I/II dose escalation study of angiotensin 1-7 [A(1-7)] administered before and after chemotherapy in patients with newly diagnosed breast cancer
Rodgers, K. E., Oliver, J., & diZerega, G. S. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-005-0078-4 · Cited by 115 · see citing works
Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
Lea, W. B., Kwak, E. S., Luther, J. M., Fowler, S. M., Wang, Z., Ma, J., Fogo, A. B., & Brown, N. J. (2009) · Kidney International · doi:10.1038/ki.2009.9 · Cited by 115 · see citing works
Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases
Ferreira, A. J., Shenoy, V., Qi, Y., Fraga-Silva, R. A., Santos, R. A. S., Katovich, M. J., & Raizada, M. K. (2010) · Experimental Physiology · doi:10.1113/expphysiol.2010.055277 · Cited by 112 · see citing works
Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension
Colussi, G., Catena, C., & Sechi, L. A. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283599b6a · Cited by 109 · see citing works
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets
Treml, B., Neu, N., Kleinsasser, A. T., Gritsch, C., Finsterwalder, T., Geiger, R., Schuster, M., Janzek, E., Loibner, H., Penninger, J. M., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c03009 · Cited by 107 · see citing works
Study of Aldosterone Synthase Inhibition as an Add‐On Therapy in Resistant Hypertension
Karns, A. D., Bral, J. M., Hartman, D., Peppard, T., & Schumacher, C. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12051 · Cited by 104 · see citing works
Aldosterone synthase inhibition in humans
Azizi, M., Amar, L., & Ménard, J. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs388 · Cited by 103 · see citing works
Phase I and Pharmacokinetic Study of Angiotensin-(1-7), an Endogenous Antiangiogenic Hormone
Petty, W. J., Miller, A. A., McCoy, T. P., Gallagher, P. E., Tallant, E. A., & Torti, F. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1957 · Cited by 102 · see citing works
Decrease of blood pressure by ventrolateral medullary decompression in essential hypertension
Geiger, H., Naraghi, R., Schobel, H., Frank, H., Sterzel, R. B., & Fahlbusch, R. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11343-5 · Cited by 102 · see citing works
Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Ocaranza, M. P., Moya, J., Barrientos, V., Alzamora, R., Hevia, D., Morales, C., Pinto, M., Escudero, N., Garcı́a, L., Novoa, U., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000094 · Cited by 100 · see citing works
Renal Denervation in Moderate Treatment-Resistant Hypertension
Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Sobotka, P. A., Veelken, R. A., Spies, A., Ukena, C., Laufs, U., Uder, M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.023 · Cited by 99 · see citing works
The Renin-Angiotensin System
Oparil, S., & Haber, E. (1974) · New England Journal of Medicine · doi:10.1056/nejm197408292910905 · Cited by 91 · see citing works
Rationale and Design of ARTS: A Randomized, Double-Blind Study of BAY 94-8862 in Patients with Chronic Heart Failure and Mild or Moderate Chronic Kidney Disease
Pitt, B., Filippatos, G. S., Gheorghiade, M., Køber, L., Krum, H., Ponikowski, P. P., Nowack, C., Kolkhof, P., Kim, S., & Zannad, F. M. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs061 · Cited by 90 · see citing works
Wilder's principle: pre-treatment value determines post-treatment response
Messerli, F. H., Bangalore, S., & Schmieder, R. E. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu467 · Cited by 90 · see citing works
Renal Denervation
Persu, A., Renkin, J. P., Thijs, L., & Staessen, J. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.195263 · Cited by 88 · see citing works
Antihypertensive and Laxative Effects by Pharmacological Inhibition of Sodium-Proton-Exchanger Subtype 3–Mediated Sodium Absorption in the Gut
Linz, D., WIRTH, K. J., Linz, W., Heuer, H., Frick, W., Hofmeister, A., Heinelt, U., Arndt, P., Schwahn, U., Böhm, M., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201590 · Cited by 87 · see citing works
An Endogenous Ouabain-Like Factor Associated with Hypertensive Pregnant Women*
Graves, S. W., & Williams, G. H. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1070 · Cited by 86 · see citing works
Improved Cardiac Structure and Function With Chronic Treatment Using an Implantable Device in Resistant Hypertension
Bisognano, J. D., Kaufman, C. L., Bach, D. S., Lovett, E. G., & de Leeuw, P. W. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.048 · Cited by 85 · see citing works
Independence of the Blood Pressure Lowering Effect and Efficacy of the Angiotensin Receptor Neprilysin Inhibitor, LCZ696, in Patients with Heart Failure with Preserved Ejection Fraction: An Analysis of the PARAMOUNT Trial
Jhund, P. S., Claggett, B. L., Packer, M., Zile, M. R., Voors, A. A., Pieske, B. M., Lefkowitz, M. P., Shi, V. C., Bransford, T. L., McMurray, J. J. V., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.76 · Cited by 83 · see citing works
PC18, a Specific Aminopeptidase N Inhibitor, Induces Vasopressin Release by Increasing the Half-Life of Brain Angiotensin III
Goazigo, A. R.-L., Mota, N. D., Zini, S., Cadel, S., Fournié‐Zaluski, M., Roques, B. P., Corvol, P. L., & Llorens‐Cortés, C. (1999) · Neuroendocrinology · doi:10.1159/000054439 · Cited by 82 · see citing works
New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin‐Converting Enzyme 2/Angiotensin‐(1–7)/Mas Receptor Axis
Ferreira, A. J., Murça, T. M., Fraga-Silva, R. A., Castro, C. H., Raizada, M. K., & Santos, R. A. S. (2012) · International Journal of Hypertension · doi:10.1155/2012/147825 · Cited by 80 · see citing works
A new strategy for treating hypertension by blocking the activity of the brain renin–angiotensin system with aminopeptidase A inhibitors
Gao, J., Marc, Y., Iturrioz, X., Leroux, V., Balavoine, F., & Llorens‐Cortés, C. (2014) · Clinical Science · doi:10.1042/cs20130396 · Cited by 80 · see citing works
Comparison of valsartan and amlodipine on ambulatory and morning blood pressure in hypertensive patients
Eguchi, K. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.09.008 · Cited by 80 · see citing works
Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats
Marc, Y., Gao, J., Balavoine, F., Michaud, A., Roques, B. P., & Llorens‐Cortés, C. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.190942 · Cited by 79 · see citing works
Improvement of albuminuria after renal denervation
Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Veelken, R., Ewen, S., Ukena, C., Uder, M., Böhm, M., & Schmieder, R. E. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.017 · Cited by 75 · see citing works
Effectiveness and Safety of a Therapeutic Vaccine Against Angiotensin II Receptor Type 1 in Hypertensive Animals
Chen, X., Qiu, Z., Yang, S., Ding, D., Chen, F., Zhou, Y., Wang, M., Lin, J., Yu, X., Zhou, Z., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201020 · Cited by 73 · see citing works
A digoxin-like immunoreactive substance in preeclampsia
Gusdon, J. P., Buckalew, V. M., & Hennessy, J. F. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(84)80114-3 · Cited by 72 · see citing works
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia
Anandan, S., Webb, H. K., Chen, D., Wang, Y., Aavula, B. R., Cases, S., Cheng, Y., Do, Z. N., Mehra, U., Tran, V., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.12.042 · Cited by 72 · see citing works
Catheter-Based Renal Denervation for Resistant Hypertension
Papademetriou, V., Tsioufis, C. P., Sinhal, A. R., Chew, D. P., Meredith, I. T., Malaiapan, Y., Worthley, M. I., & Worthley, S. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03605 · Cited by 72 · see citing works
Ethanol-mediated perivascular renal sympathetic denervation: preclinical validation of safety and efficacy in a porcine model
Fischell, T. A., Vega, F., Raju, N. R., Johnson, E. T., Kent, D. J., Ragland, R. R., Fischell, D. R., ALMANY, S. L., & Ghazarossian, V. E. (2013) · EuroIntervention · doi:10.4244/eijv9i1a20 · Cited by 71 · see citing works
THE EFFECTS OF SPIRONOLACTONE AND CHLORTHALIDONE ON ARTERIAL PRESSURE
Cranston, W. I., & Juel‐Jensen, B. E. (1962) · The Lancet · doi:10.1016/s0140-6736(62)92199-2 · Cited by 70 · see citing works
Inhibition of soluble epoxide hydrolase bycis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension
Neckář, J., Kopkan, L., Husková, Z., Kolář, F., Papoušek, F., Kramer, H. J., Hwang, S. H., Hammock, B. D., Imig, J. D., Malý, J., et al. (2011) · Clinical Science · doi:10.1042/cs20110622 · Cited by 70 · see citing works
The Effects of Aldosterone Synthase Inhibition on Aldosterone and Cortisol in Patients With Hypertension: A Phase II, Randomized, Double‐Blind, Placebo‐Controlled, Multicenter Study
Andersen, K. K., Hartman, D., Peppard, T., Hermann, D. J., Ess, P. J. V., Lefkowitz, M. P., & Trapani, A. J. (2012) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2012.00667.x · Cited by 70 · see citing works
Antidigoxin Antibodies in Eclampsia
Rc, G. (1988) · New England Journal of Medicine · doi:10.1056/nejm198802253180815 · Cited by 70 · see citing works
Natriuretic Peptide Receptor-C Attenuates Hypertension in Spontaneously Hypertensive Rats
Li, Y., Sarkar, O., Brochu, M., & Anand‐Srivastava, M. B. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01772 · Cited by 69 · see citing works
Beneficial Effects of Long‐Term Administration of an Oral Formulation of Angiotensin‐(1–7) in Infarcted Rats
Marques, F. D., Melo, M. B., de Souza, L. E., Irigoyen, M. C., Sinisterra, R. D., Sousa, F. B. D., Savergnini, S. Q., Braga, V. B. A., Ferreira, A. J., & Santos, R. A. S. (2012) · International Journal of Hypertension · doi:10.1155/2012/795452 · Cited by 65 · see citing works
Renal sympathetic denervation therapy in the real world: results from the Heidelberg registry
Vogel, B., Kirchberger, M. C., Zeier, M. G., Stoll, F., Meder, B., Saure, D., Andrassy, M., Mueller, O. J., Hardt, S. E., Schwenger, V., et al. (2013) · Clinical Research in Cardiology · doi:10.1007/s00392-013-0627-5 · Cited by 64 · see citing works
Aldosterone Synthase Inhibitors as Promising Treatments for Mineralocorticoid Dependent Cardiovascular and Renal Diseases
Hu, Q., Yin, L., & Hartmann, R. W. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401430e · Cited by 63 · see citing works
Opportunities for Targeting the Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Receptor Pathway in Hypertension
Fraga-Silva, R. A., Ferreira, A. J., & Santos, R. A. S. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0324-1 · Cited by 63 · see citing works
Studies on Renin Antibodies
Helmer, O. M. (1958) · Circulation · doi:10.1161/01.cir.17.4.648 · Cited by 63 · see citing works
Synthesis and Biological Evaluation of Novel, Peripherally Selective Chromanyl Imidazolethione-Based Inhibitors of Dopamine β-Hydroxylase
Беляев, А. Н., Learmonth, D. A., & Soares-da-Silva, P. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm051051f · Cited by 62 · see citing works
Pulsatile Compression of the Rostral Ventrolateral Medulla in Hypertension
Morimoto, S., Sasaki, S., Miki, S., Kawa, T., Itoh, H., Nakata, T., Takeda, K., Nakagawa, M., Naruse, S., & Maeda, T. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.514 · Cited by 62 · see citing works
Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug
Balavoine, F., Azizi, M., Bergerot, D., Mota, N. D., Patouret, R., Roques, B. P., & Llorens‐Cortés, C. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0125-y · Cited by 59 · see citing works
Effects of chronic baroreceptor unloading on blood pressure in the dog
Thrasher, T. N. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00489.2004 · Cited by 59 · see citing works
Angiotensin 1–7: A peptide for preventing and treating metabolic syndrome
Santos, S. H. S., & Andrade, J. M. O. (2014) · Peptides · doi:10.1016/j.peptides.2014.07.002 · Cited by 58 · see citing works
Noninvasive Renal Sympathetic Denervation by Extracorporeal High-Intensity Focused Ultrasound in a Pre-Clinical Canine Model
Wang, Q., Guo, R., Rong, S., Yang, G., Zhu, Q., Jiang, Y., Deng, C., Liu, D., Zhou, Q., Wu, Q., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.050 · Cited by 58 · see citing works
Investigation of aldosterone-synthase inhibition in rats
Ménard, J., Gonzalez, M.-F., Guyene, T.-T., & Bissery, A. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000226205.65442.f2 · Cited by 57 · see citing works
Novel Pyridyl- or Isoquinolinyl-Substituted Indolines and Indoles as Potent and Selective Aldosterone Synthase Inhibitors
Yin, L., Hu, Q., Emmerich, J., Lo, M. M. ‐., Metzger, E., Ali, A., & Hartmann, R. W. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500140c · Cited by 57 · see citing works
Deactivation of carotid body chemoreceptors by hyperoxia decreases blood pressure in hypertensive patients
Siński, M., Lewandowski, J., Przybylski, J., Zalewski, P., Symonides, B., Abramczyk, P., & Gaciong, Z. A. (2014) · Hypertension Research · doi:10.1038/hr.2014.91 · Cited by 56 · see citing works
Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy
Schumacher, C., Steele, R. E., & Brunner, H. R. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363570c · Cited by 56 · see citing works
Volume sensitive hypertension and the digoxin-like factor reversal by a fab directed against digoxin in DOCA-salt hypertensive rats
Krep, H., Price, D. A., Soszynski, P. A., Tao, Q., Graves, S. W., & Hollenberg, N. K. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00181-n · Cited by 54 · see citing works
Evaluation of two carrier protein–angiotensin I conjugate vaccines to assess their future potential to control high blood pressure (hypertension) in man
Downham, M. R., Auton, T. R., Rosul, A., Sharp, H. L., Sjöström, L., Rushton, A. B., Richards, J. P., Mant, T., Gardiner, S. M., Bennett, T. M., et al. (2003) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2003.01926.x · Cited by 53 · see citing works
Decrease in Blood Pressure and Regression of Cardiovascular Complications by Angiotensin II Vaccine in Mice
Nakagami, F., Koriyama, H., Nakagami, H., Osako, M. K., Shimamura, M., Kyutoku, M., Miyake, T., Katsuya, T., Rakugi, H., & Morishita, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060493 · Cited by 53 · see citing works
Aldosterone synthase inhibitors in hypertension: current status and future possibilities
Hargovan, M., & Ferro, A. (2014) · JRSM Cardiovascular Disease · doi:10.1177/2048004014522440 · Cited by 53 · see citing works
Creation of an iliac arteriovenous shunt lowers blood pressure in chronic obstructive pulmonary disease patients with hypertension
Faul, J. L., Schoors, D. F., Brouwers, S., Scott, B., Jerrentrup, A., Galvin, J., Luitjens, S. F., & Dolan, E. (2014) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2013.10.069 · Cited by 52 · see citing works
Why are mineralocorticoid receptor antagonists cardioprotective?
Chai, W., & Danser, A. H. J. (2006) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-006-0107-9 · Cited by 51 · see citing works
Arteriovenous Anastomosis
Burchell, A. E., Lobo, M. D., Sulke, N., Sobotka, P. A., & Paton, J. F. R. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.02925 · Cited by 51 · see citing works
Rationale and study design of the Prospective comparison of Angiotensin Receptor neprilysin inhibitor with Angiotensin receptor blocker MEasuring arterial sTiffness in the eldERly (PARAMETER) study
Williams, B., Cockcroft, J. R., Kario, K., Zappe, D., Cardenas, P., Hester, A., Brunel, P., & Zhang, J. Y. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004254 · Cited by 51 · see citing works
Neprilysin Inhibition — A Novel Therapy for Heart Failure
Jessup, M. L. (2014) · New England Journal of Medicine · doi:10.1056/nejme1409898 · Cited by 48 · see citing works
The Novel Mas agonist, CGEN-856S, Attenuates Isoproterenol-Induced Cardiac Remodeling and Myocardial Infarction Injury in Rats
Savergnini, S. Q., Ianzer, D. A., Carvalho, M. B. L., Ferreira, A. J., Silva, G. A. B., Marques, F. D., Peluso, A. A., Beiman, M., Cojocaru, G., Cohen, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057757 · Cited by 46 · see citing works
Effect of single doses of SLV306, an inhibitor of both neutral endopeptidase and endothelin-converting enzyme, on pulmonary pressures in congestive heart failure
Dickstein, K., de Voogd, H. J., Mirić, M., Willenbrock, R., Mitrović, V. L., Pacher, R., & Koopman, P. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.03.074 · Cited by 43 · see citing works
Proper Patient Selection Yields Significant and Sustained Reduction in Systolic Blood Pressure Following Renal Artery Stenting in Patients With Uncontrolled Hypertension: Long‐Term Results From the HERCULES Trial
Chrysant, G. S., Bates, M. C., Sullivan, T. M., Bachinsky, W., Popma, J. J., Peng, L., Omran, H. L., Jaff, M. R., & the HERCULES Investigators (2014) · Journal of Clinical Hypertension · doi:10.1111/jch.12341 · Cited by 43 · see citing works
Renal Artery Revascularization
Bavry, A. A., Kapadia, S. R., Bhatt, D. L., & Kumbhani, D. J. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.4332 · Cited by 43 · see citing works
Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial
Parvanova, A. I., van der Meer, I. M., Iliev, I. P., Perna, A., Gaspari, F., Trevisan, R., Bossi, A. C., Remuzzi, G., Benigni, A., & Ruggenenti, P. L. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70029-9 · Cited by 43 · see citing works
Renal Denervation for Resistant Hypertension
Rodríguez‐Leor, O., Bonet, J., & Bayés‐Genís, A. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1405677 · Cited by 42 · see citing works
Impact of the AT2 Receptor Agonist C21 on Blood Pressure and Beyond
Foulquier, S., Steckelings, U. M., & Unger, T. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0291-6 · Cited by 41 · see citing works
Disproportional Decrease in Office Blood Pressure Compared With 24-Hour Ambulatory Blood Pressure With Antihypertensive Treatment
Schmieder, R. E., Schmidt, S. T., Riemer, T., Dechend, R., Hagedorn, I., Senges, J., Messerli, F. H., & Zeymer, U. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.03140 · Cited by 41 · see citing works
Effect of combination of renin inhibitor and Mas-receptor agonist in DOCA–salt-induced hypertension in rats
Singh, Y. P., Singh, K., & Sharma, P. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1489-2 · Cited by 40 · see citing works
Blood pressure response to renal artery stenting in 901 patients from five prospective multicenter FDA‐approved trials
Weinberg, I., Keyes, M. J., Giri, J., Rogers, K. R., Olin, J. W., White, C. J., & Jaff, M. R. (2014) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.25263 · Cited by 38 · see citing works
Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism
Amar, L., Azizi, M., Ménard, J., Peyrard, S., & Plouin, P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835d6d49 · Cited by 38 · see citing works
HORMONAL AND ELECTROLYTE RESPONSES TO THE ALDOSTERONE SYNTHASE INHIBITOR LCI699 IN SODIUM DEPLETED HEALTHY SUBJECTS
Ménard, J., Watson, C. E., Rebello, S. S., Zhang, Y. M., & Dole, W. P. (2010) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)60584-0 · Cited by 38 · see citing works
Temporary Reduction of Blood Pressure and Sympathetic Nerve Activity in Hypertensive Patients After Microvascular Decompression
Frank, H., Heusser, K., Geiger, H., Fahlbusch, R., Naraghi, R., & Schobel, H. P. (2008) · Stroke · doi:10.1161/strokeaha.108.518670 · Cited by 38 · see citing works
Microvascular Decompression for Hypertension
Yamamoto, I., Yamada, S., & Sato, O. (1991) · Neurologia medico-chirurgica · doi:10.2176/nmc.31.1 · Cited by 37 · see citing works
Aminopeptidase A inhibitors as centrally acting antihypertensive agents
Bodineau, L., Frugière, A., Marc, Y., Claperon, C., & Llorens‐Cortés, C. (2008) · Heart Failure Reviews · doi:10.1007/s10741-007-9077-3 · Cited by 37 · see citing works
Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes
Tikkanen, I. T., Tikkanen, T., Cao, Z., Allen, T. J., Davis, B. J., Lassila, M., CASLEY, D. J., Johnston, C. I., Burrell, L. M., & Cooper, M. E. (2002) · Journal of Hypertension · doi:10.1097/00004872-200204000-00029 · Cited by 36 · see citing works
Success and failure of vaccines against renin–angiotensin system components
Brown, M. J. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.156 · Cited by 35 · see citing works
Etamicastat, a Novel Dopamine β-Hydroxylase Inhibitor: Tolerability, Pharmacokinetics, and Pharmacodynamics in Patients With Hypertension
Almeida, L., Nunes, T., Costa, R., Rocha, J., Vaz‐da‐Silva, M., & Soares-da-Silva, P. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.10.012 · Cited by 32 · see citing works
Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?
Ménard, J., & Pascoe, L. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000226183.98439.b3 · Cited by 31 · see citing works
Long-Term Results After Microvascular Decompression in Essential Hypertension
Frank, H., Schobel, H.-P., Heusser, K., Geiger, H., Fahlbusch, R., & Naraghi, R. (2001) · Stroke · doi:10.1161/hs1201.099799 · Cited by 30 · see citing works
Digoxin Immune Fab Treatment for Severe Preeclampsia
Adair, C. D., Buckalew, V. M., Graves, S. W., Lam, G. K., Johnson, D., Saade, G. R., Lewis, D. F., Robinson, C., Danoff, T. M., Chauhan, N., et al. (2010) · American Journal of Perinatology · doi:10.1055/s-0030-1249762 · Cited by 30 · see citing works
The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans
Seed, A., Kuc, R. E., Maguire, J. J., Hillier, C., Johnston, F., Essers, H., de Voogd, H. J., McMurray, J. J. V., & Davenport, A. P. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.03.022 · Cited by 30 · see citing works
In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator
Edelson, J. D., Makhlina, M., Silvester, K. R., Vengurlekar, S. S., Chen, X., Zhang, J., Koziol‐White, C. J., Cooper, P. R., Hallam, T. J., Hay, D. W. P., et al. (2012) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2012.11.001 · Cited by 29 · see citing works
Digoxin antibody fragment, antigen binding (Fab), treatment of preeclampsia in women with endogenous digitalis-like factor: a secondary analysis of the DEEP Trial
Lam, G. K., Hopoate-Sitake, M., Adair, C. D., Buckalew, V. M., Johnson, D., Lewis, D. F., Robinson, C., Saade, G. R., & Graves, S. W. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.04.010 · Cited by 29 · see citing works
From SYMPLICITY HTN-3 to the Renal Denervation Global Registry: where do we stand and where should we go?
Pathak, A., Ewen, S., Fajadet, J. C., Honton, B., Mahfoud, F., Marco, J., Schlaich, M. P., Schmieder, R. E., Tsioufis, K. P., Ukena, C., et al. (2014) · EuroIntervention · doi:10.4244/eijv10i1a4 · Cited by 29 · see citing works
Immediate Effects of Bilateral Carotid Body Resection on Total Respiratory Resistance and Compliance in Humans
Winter, B., & Whipp, B. J. (2004) · Advances in experimental medicine and biology · doi:10.1007/0-387-27023-x_3 · Cited by 27 · see citing works
Aldosterone, Hypertension, and Cardiovascular Disease
Ruilope, L. M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111211 · Cited by 26 · see citing works
Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat
Igreja, B., Pires, N. M., Bonifácio, M. J., Loureiro, A. I., Fernandes‐Lopes, C., Wright, L. C., & Soares-da-Silva, P. (2014) · Hypertension Research · doi:10.1038/hr.2014.143 · Cited by 25 · see citing works
Inhibition of Both Neutral Endopeptidase and Endothelin-Converting Enzyme by SLV306 Reduces Proteinuria and Urinary Albumin Excretion in Diabetic Rats
ne-Reinke, C. T., Simon, K., Richter, C.-M., Godes, M., Neumayer, H., hlen, D. T., & Hocher, B. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000166208.12297.8d · Cited by 25 · see citing works
Aldosterone synthase inhibitors: pharmacological and clinical aspects.
Jansen, P. M., van den Meiracker, A. H., & Danser, A. J. (2009) · PubMed · Cited by 22 · see citing works
Immunologic approaches to blockade of the renin-angiotensin system: A review
Michel, J., Guettier, C., Reade, R., Sayah, S., Corvol, P. L., & Ménard, J. (1989) · American Heart Journal · doi:10.1016/0002-8703(89)90767-9 · Cited by 22 · see citing works
Hypertension Vaccine may be a boon to millions in developing world
Bairwa, M. L., Pilania, M., Gupta, V., & Yadav, K. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.27520 · Cited by 19 · see citing works
DigiFab Interacts With Endogenous Cardiotonic Steroids and Reverses Preeclampsia-Induced Na/K-ATPase Inhibition
Ishkaraeva, V. V., Fedorova, O. V., Solodovnikova, N. G., Frolova, E. V., Bzhelyansky, A., Emelyanov, I. V., Adair, D. C., Zazerskaya, I. E., & Bagrov, A. Y. (2012) · Reproductive Sciences · doi:10.1177/1933719112447124 · Cited by 19 · see citing works
Construction, expression and immunogenicity of a novel anti-hypertension angiotensin II vaccine based on hepatitis A virus-like particle
Ou, X., Guo, L., Wu, J., Mi, K., Yin, N., Zhang, G., Li, H., & Sun, M. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.23940 · Cited by 18 · see citing works
Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia ( PRESERVE ‐1)
Paidas, M. J., Sibai, B. M., Triche, E. W., Frieling, J. T. M., Lowry, S., & The PRESERVE‐1 Study Group (2013) · American Journal of Reproductive Immunology · doi:10.1111/aji.12091 · Cited by 17 · see citing works
Angiotensin‐(1‐7)/Angiotensin‐Converting Enzyme 2/Mas Receptor Axis and Related Mechanisms
Ferreira, A. J., Santos, R. A. S., & Raizada, M. K. (2012) · International Journal of Hypertension · doi:10.1155/2012/690785 · Cited by 15 · see citing works

Flagged first, then by citations

1 of the 213 references couldn’t be matched to a known paper.

Sorted by citations

Hypertension.
Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.14 · Cited by 1,167 · see citing works
Self-citation
Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management
Burnier, M., & Egan, B. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313220 · Cited by 878 · see citing works
Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19
Kreutz, R. H., Algharably, E. A. E., Azizi, M., Dobrowolski, P., Guzik, T. J., Januszewicz, A., Persu, A., Prejbisz, A., Riemer, T., Wang, J., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa097 · Cited by 356 · see citing works
Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure
Coulson, L. B., Danser, A. H. J., Poglitsch, M., Touyz, R. M., Burnett, J. C. J., Llorens‐Cortés, C., Ehlers, M. R., & Sturrock, E. D. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.017129 · Cited by 341 · see citing works
COVID-19 patients with hypertension have more severe disease: a multicenter retrospective observational study
Huang, S., Wang, J., Liu, F., Liu, J., Cao, G., Yang, C., Liu, W. Y., Tu, C., Zhu, M., & Xiong, B. (2020) · Hypertension Research · doi:10.1038/s41440-020-0485-2 · Cited by 227 · see citing works
Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines
Despanie, J., Dhandhukia, J. P., Hamm‐Alvarez, S. F., & MacKay, J. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.11.010 · Cited by 177 · see citing works
Dietary fiber and blood pressure control
Aleixandre, A., & Miguel, M. (2016) · Food & Function · doi:10.1039/c5fo00950b · Cited by 156 · see citing works
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma
Sun, X.-N., Li, C., Liu, Y., Du, L., Zeng, M., Zheng, X., Zhang, W.-C., Liu, Y., Zhu, M., Kong, D., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.310480 · Cited by 134 · see citing works
Renin angiotensin aldosterone inhibition in the treatment of cardiovascular disease
Ferrario, C. M., & Mullick, A. E. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.020 · Cited by 121 · see citing works
Assessment of sympathetic neural activity in chronic insomnia: evidence for elevated cardiovascular risk
Carter, J. R., Grimaldi, D., Fonkoue, I. T., Medalie, L., Mokhlesi, B., & Cauter, E. V. (2018) · SLEEP · doi:10.1093/sleep/zsy048 · Cited by 110 · see citing works
Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and Dysfunction
Zhang, Z.-Z., Wang, W., Jin, H., Chen, X., Cheng, Y., Xu, Y., Song, B., Penninger, J. M., Oudit, G. Y., & Zhong, J. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.10156 · Cited by 107 · see citing works
Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22
Karnik, S. S., Singh, K. D., Tirupula, K. C., & Ünal, H. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13742 · Cited by 105 · see citing works
Methods and challenges for assessing heterogeneity
Feczko, E., & Fair, D. A. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.015 · Cited by 96 · see citing works
Reprogramming: A Preventive Strategy in Hypertension Focusing on the Kidney
Tain, Y., & Joles, J. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010023 · Cited by 96 · see citing works
Nanocarriers as treatment modalities for hypertension
Alam, T., Khan, S., Gaba, B., Haider, M. F., Baboota, S., & Ali, J. (2017) · Drug Delivery · doi:10.1080/10717544.2016.1255999 · Cited by 92 · see citing works
Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors
Silva, G., SILVA, M. S. D. O., Nascimento, D., Silva, E. L., Gouvêa, F. F. F., Lopes, L. G. D. F., Araújo, A. V., Ferraz‐Pereira, K. N., & de Queiroz, T. M. (2021) · Biology · doi:10.3390/biology10101041 · Cited by 96 · see citing works
Novel therapeutics for the treatment of hypertension and its associated complications: peptide- and nonpeptide-based strategies
Ghatage, T., Goyal, S., Dhar, A., & Bhat, A. (2021) · Hypertension Research · doi:10.1038/s41440-021-00643-z · Cited by 91 · see citing works
Patient preference for therapies in hypertension: a cross-sectional survey of German patients
Schmieder, R. E., Högerl, K., Jung, S., Bramlage, P., Veelken, R. A., & Ott, C. (2019) · Clinical Research in Cardiology · doi:10.1007/s00392-019-01468-0 · Cited by 86 · see citing works
The Role of Renin–Angiotensin–Aldosterone System and Its New Components in Arterial Stiffness and Vascular Aging
Neves, M. F., Cunha, A. R., Cunha, M. R., Gismondi, R. A., & Oigman, W. (2018) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-018-0252-5 · Cited by 85 · see citing works
Drug Treatment of Hypertension: Focus on Vascular Health
Cameron, A. C., Lang, N. N., & Touyz, R. M. (2016) · Drugs · doi:10.1007/s40265-016-0642-8 · Cited by 83 · see citing works
Glucocorticoid and mineralocorticoid receptors and corticosteroid homeostasis are potential targets for endocrine-disrupting chemicals
Zhang, J., Yang, Y., Liu, W., Schlenk, D., & Liu, J. (2019) · Environment International · doi:10.1016/j.envint.2019.105133 · Cited by 80 · see citing works
The Vasoactive Mas Receptor in Essential Hypertension
Povlsen, A. L., Grimm, D. G., Wehland, M., Infanger, M., & Krüger, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010267 · Cited by 75 · see citing works
Phase II randomized sham-controlled study of renal denervation for individuals with uncontrolled hypertension – WAVE IV
Schmieder, R. E., Ott, C., Toennes, S. W., Bramlage, P., Gertner, M. E., Dawood, O., Baumgart, P., O’Brien, B., Dasgupta, I., Nickenig, G., et al. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001584 · Cited by 75 · see citing works
Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway
Cheng, Y., Shen, A., Wu, X., Shen, Z., Chen, X., Li, J., Liu, L., Lin, X., Wu, M., Chen, Y., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111022 · Cited by 74 · see citing works
European Society of Hypertension position paper on renal denervation 2018
Schmieder, R. E., Mahfoud, F., Azizi, M., Pathak, A., Dimitriadis, K. S., Kroon, A. A., Ott, C., Scalise, F., Mancia, G., & Tsioufis, C. P. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001858 · Cited by 66 · see citing works
The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges
Wang, Z., Ye, D., Ye, J., Wang, M., Liu, J., Jiang, H., Xu, Y. Q., Zhang, J., Chen, J., & Wan, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01253 · Cited by 64 · see citing works
Pathophysiology of Intestinal Na+/H+ Exchange
Gurney, M. A., Laubitz, D., Ghishan, F. K., & Kiela, P. R. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.09.010 · Cited by 60 · see citing works
The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling
Zhang, Z.-Z., Cheng, Y., Jin, H., Chang, Q. H., Shang, Q., Xu, Y., Chen, L., Xu, R., Song, B., & Zhong, J. (2017) · Oncotarget · doi:10.18632/oncotarget.20305 · Cited by 59 · see citing works
Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury
Öz, M., & Lorke, D. E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111193 · Cited by 55 · see citing works
Immunotherapy of Endothelin-1 Receptor Type A for Pulmonary Arterial Hypertension
Dai, Y., Chen, X., Song, X., Chen, X., Ma, W., Lin, J., Wu, H., Hu, X., Zhou, Y., Zhang, H., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.02.067 · Cited by 55 · see citing works
Central sympathetic nerve activation in subarachnoid hemorrhage
Hasegawa, Y., Uchikawa, H., Kajiwara, S., & Morioka, M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15511 · Cited by 55 · see citing works
Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review
Bhuia, M. S., Wilairatana, P., Ferdous, J., Chowdhury, R., Bappi, M. H., Rahman, M. A., Mubarak, M. S., & Islam, M. T. (2023) · Molecules · doi:10.3390/molecules28166141 · Cited by 53 · see citing works
Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation
Patel, P., Gupta, P., White, C., Stanley, A. G., Williams, B., & Tomaszewski, M. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.103 · Cited by 54 · see citing works
Preventive Cardiology as a Subspecialty of Cardiovascular Medicine
Shapiro, M. D., Maron, D. J., Morris, P. B., Kosiborod, M., Sandesara, P. B., Virani, S. S., Khera, A., Ballantyne, C. M., Baum, S. J., Sperling, L. S., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.08.1016 · Cited by 53 · see citing works
Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins
Hsu, C., & Tain, Y. (2021) · Biomedicines · doi:10.3390/biomedicines9060623 · Cited by 53 · see citing works
Calcium Signaling Dynamics in Vascular Cells and Their Dysregulation in Vascular Disease
Dai, C., & Khalil, R. A. (2025) · Biomolecules · doi:10.3390/biom15060892 · Cited by 52 · see citing works
Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to β-Blockers in Hypertensive African Americans
Gong, Y., Wang, Z., Beitelshees, A. L., McDonough, C. W., Langaee, T. Y., Hall, K., Schmidt, S. O., Curry, R. W., Gums, J. G., Bailey, K. R., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06345 · Cited by 50 · see citing works
The benefits of soluble non-bacterial fraction of kefir on blood pressure and cardiac hypertrophy in hypertensive rats are mediated by an increase in baroreflex sensitivity and decrease in angiotensin-converting enzyme activity
Brasil, G. A., Silva‐Cutini, M. A., Moraes, F. D. S. A., Pereira, T. D. M. C., Vasquez, E. C., Lenz, D., Bissoli, N. S., Endringer, D. C., de Lima, E. M., Biancardi, V. C., et al. (2018) · Nutrition · doi:10.1016/j.nut.2017.12.007 · Cited by 50 · see citing works
Changes in Hypertension Prevalence, Awareness, Treatment, and Control in High-, Middle-, and Low-Income Countries: An Update
Cífková, R., Fodor, G. J., & Wohlfahrt, P. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0669-y · Cited by 48 · see citing works
Inhibitory activities of grape bioactive compounds against enzymes linked with human diseases
Dwibedi, V., Jain, S., Singhal, D., Mittal, A., Rath, S. K., & Saxena, S. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11801-9 · Cited by 47 · see citing works
Solubility of prazosin hydrochloride (alpha blocker antihypertensive drug) in supercritical CO2: Experimental and thermodynamic modelling
Sodeifian, G., Alwi, R. S., Razmimanesh, F., & Sodeifian, F. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.119689 · Cited by 47 · see citing works
Discovery and Characterization of Allosteric WNK Kinase Inhibitors
Yamada, K., Zhang, J.-H., Xie, X., Reinhardt, J., Xie, A. Q., LaSala, D., Kohls, D., Yowe, D. L., Burdick, D., Yoshisue, H., et al. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00511 · Cited by 46 · see citing works
First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension
Chen, H. H., Wan, S., Iyer, S. R., Cannone, V., Sangaralingham, S. J., Nuetel, J., & Burnett, J. C. J. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17159 · Cited by 46 · see citing works
Mega clinical trials which have shaped the RAS intervention clinical practice
Düsing, R. (2016) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944716644131 · Cited by 43 · see citing works
Resistant Hypertension: Mechanisms and Treatment
Hwang, A. Y., Dietrich, E. A., Pepine, C. J., & Smith, S. M. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0754-x · Cited by 47 · see citing works
Neurohumoral and Endothelial Responses to Heated Water-Based Exercise in Resistant Hypertensive Patients
Cruz, L. G. D. B., Bocchi, E. A., Grassi, G. M., & Guimarães, G. V. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0870 · Cited by 44 · see citing works
Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation
Gan, Z., Huang, D., Jiang, J., Li, Y., Li, H., & Ke, Y. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187338 · Cited by 43 · see citing works
Identification and Antihypertension Study of Novel Angiotensin I-Converting Enzyme Inhibitory Peptides from the Skirt of Chlamys farreri Fermented with Bacillus natto
Gao, J., Liu, Q., Zhao, L., Yu, J., Wang, S., Cao, T., Gao, X., & Wei, Y. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04232 · Cited by 42 · see citing works
Hypertensive heart disease and myocardial fibrosis: How traditional Chinese medicine can help addressing unmet therapeutical needs
Liu, M., Long, X., Xu, J., Chen, M., Yang, H., Guo, X., Kang, J., Ouyang, Y., Luo, G., Yang, S., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106515 · Cited by 41 · see citing works
3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow
Maier, M. C., Valotta, A., Hiebler, K., Soritz, S., Gavric, K., Grabner, B., & Gruber‐Wölfler, H. (2020) · Organic Process Research & Development · doi:10.1021/acs.oprd.0c00228 · Cited by 39 · see citing works
Externally Delivered Focused Ultrasound for Renal Denervation
Neužil, P., Ormiston, J. A., Brinton, T. J., Stárek, Z., Esler, M., Dawood, O., Anderson, T. L., Gertner, M. E., Whitbourne, R., & Schmieder, R. E. (2016) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2016.04.013 · Cited by 38 · see citing works
Renal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension
Chen, H., Cheng, P., Ho, W.-Y., Lu, P., Lai, C.-C., Tseng, Y.-M., Fang, H.-C., Sun, G., Hsiao, M., Liu, C.-P., et al. (2016) · Scientific Reports · doi:10.1038/srep38447 · Cited by 38 · see citing works
Association Between Systemic Inflammation, Carotid Arteriosclerosis, and Autonomic Dysfunction
Rupprecht, S., Finn, S., Hoyer, D., Guenther, A., Witte, O. W., Schultze, T., & Schwab, M. G. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00706-x · Cited by 37 · see citing works
Epochs in the depressor/pressor balance of the renin–angiotensin system
Colafella, K. M. M., Hilliard, L. M., & Denton, K. M. (2016) · Clinical Science · doi:10.1042/cs20150939 · Cited by 36 · see citing works
Future drug discovery in renin-angiotensin-aldosterone system intervention
Tamargo, M., & Tamargo, J. L. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1335301 · Cited by 34 · see citing works
Pacemaker‐Mediated Programmable Hypertension Control Therapy
Neužil, P., Merkely, B. P., Ērglis, A., Marinskis, G., de Groot, J. R., Schmidinger, H., Venegas, M. R., Voskuil, M., Sturmberger, T., Petrů, J., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006974 · Cited by 34 · see citing works
Pharmacological modulation of vascular ageing: A review from VascAgeNet
Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 36 · see citing works
Altered microRNA regulation of short chain fatty acid receptors in the hypertensive kidney is normalized with hydrogen sulfide supplementation
Weber, G. J., Foster, J., Pushpakumar, S. B., & Sen, U. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.06.012 · Cited by 33 · see citing works
Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes
Tu, H., Zhang, D.-Z., & Li, Y.-L. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0274-y · Cited by 29 · see citing works
Silkworm pupa protein and its peptides: Preparation, biological activity, applications in foods, and advantages
Wu, X., Yang, J., Mumby, W., Zhang, Y., Zhang, Y., Wang, C., Chen, X., Suo, H., & Song, J. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104129 · Cited by 31 · see citing works
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy
Clark, C. R., & Khalil, R. A. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115963 · Cited by 31 · see citing works
Role of Paced Breathing for Treatment of Hypertension
Cernes, R., & Zimlichman, R. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0742-1 · Cited by 31 · see citing works
Pacemaker‐Based Cardiac Neuromodulation Therapy in Patients With Hypertension: A Pilot Study
Kalarus, Z. F., Merkely, B. P., Neužil, P., Grabowski, M., Mitkowski, P. P., Marinskis, G., Ērglis, A., Kaźmierczak, J., Sturmberger, T., Sokal, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.020492 · Cited by 30 · see citing works
Pathogenesis of Hypertension
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 33 · see citing works
Mathematically Processed UV Spectroscopic Method for Quantification of Chlorthalidone and Azelnidipine in Bulk and Formulation: Evaluation of Greenness and Whiteness
Attimarad, M., Chohan, M. S., Venugopala, K. N., Nair, A. B., Nagaraja, S., Shafi, S., David, M., Balgoname, A. A., Altaysan, A. I., Molina, E. I. P., et al. (2022) · Journal of Spectroscopy · doi:10.1155/2022/4965138 · Cited by 29 · see citing works
Targeting gut S. aureofaciens Tü117 serves as a new potential therapeutic intervention for the prevention and treatment of hypertension
Zhou, T., Wang, Z., Lv, X., Guo, M., Zhang, N., Liu, L., Geng, L., Shao, J., Zhang, K., Gao, M., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.004 · Cited by 28 · see citing works
Systems pharmacology–based integration of human and mouse data for drug repurposing to treat thoracic aneurysms
Hansen, J., Galatioto, J., Caescu, C. I., Arnaud, P., Calizo, R. C., Spronck, B., Murtada, S., Borkar, R. M., Weinberg, A. D., Azeloglu, E. U., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127652 · Cited by 28 · see citing works
Central Iliac Arteriovenous Anastomosis for Hypertension: Targeting Mechanical Aspects of the Circulation
Kapil, V., Sobotka, P. A., Saxena, M., Mathur, A., Knight, C. J., Dolan, E., Stanton, A. V., & Lobo, M. D. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0585-6 · Cited by 28 · see citing works
Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)
Burgoyne, J. R., Prysyazhna, O. D., Richards, D. A., & Eaton, P. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09670 · Cited by 28 · see citing works
Stress, Genes, and Hypertension. Contribution of the ISIAH Rat Strain Study
Redina, O. E., & Markel, А. L. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0870-2 · Cited by 28 · see citing works
Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach
Chen, C., Guo, C., Gao, J., Shi, K., Cheng, J., Zhang, J., Chen, S., Liu, Y., & Liu, A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.061 · Cited by 28 · see citing works
Androgen-sensitive hypertension associated with soluble guanylate cyclase alpha1 deficiency is mediated by 20-HETE
Dordea, A., Vandenwijngaert, S., Garcia, V., Tainsh, R., Nathan, D. I., Allen, K., Raher, M. J., Tainsh, L. T., Zhang, F., Lieb, W. S., et al. (2015) · BMC Pharmacology and Toxicology · doi:10.1152/ajpheart.00877.2015 · Cited by 15 · see citing works
Posicionamento Brasileiro sobre Hipertensão Arterial Resistente – 2020
Yugar‐Toledo, J. C., Moreno, H., Gus, M., Rosito, G. B. A., Scala, L. C. N., Muxfeldt, E. S., Alessi, A., Brandão, A. A., Filho, O. M., Feitosa, A. D. M., et al. (2020) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20200198 · Cited by 28 · see citing works
Local angiotensin-(1–7) administration improves microvascular endothelial function in women who have had preeclampsia
Stanhewicz, A. E., & Alexander, L. M. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00221.2019 · Cited by 26 · see citing works
Bioactive Peptides and Exercise Modulate the AMPK/SIRT1/PGC-1α/FOXO3 Pathway as a Therapeutic Approach for Hypertensive Rats
Ho, J., Baskaran, R., Wang, M.-F., Yang, H., Lo, Y., Mohammedsaleh, Z. M., & Lin, W. (2022) · Pharmaceuticals · doi:10.3390/ph15070819 · Cited by 26 · see citing works
Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats
Carvalho‐Galvão, A., Ogunlade, B., Xu, J., Silva-Alves, C. R. A., Mendes-Júnior, L. G., Guimarães, D. D., Cruz, J. C., de Queiroz, T. M., Balarini, C. M., Braga, V. A., et al. (2018) · Clinical Science · doi:10.1042/cs20180222 · Cited by 26 · see citing works
Iron–Immune Crosstalk at the Maternal–Fetal Interface: Emerging Mechanisms in the Pathogenesis of Preeclampsia
Zhong, J., Jiang, R., Liu, N., Cai, Q., Cao, Q., Du, Y., & Zhao, H. (2025) · Antioxidants · doi:10.3390/antiox14070890 · Cited by 29 · see citing works
Vascular hyperpolarization in human physiology and cardiovascular risk conditions and disease
Schinzari, F., Tesauro, M., & Cardillo, C. (2015) · Acta Physiologica · doi:10.1111/apha.12630 · Cited by 25 · see citing works
Psyllium Husk (Plantago ovata) as a Potent Hypocholesterolemic Agent in Animal, Human and Poultry
Xing, L. C., Santhi, D., Shar, A. G., Saeed, M., Arain, M. A., Shar, A. H., Bhutto, Z. A., Kakar, M. U., Manzoor, R., El-Hack, M. E. A., et al. (2017) · International Journal of Pharmacology · doi:10.3923/ijp.2017.690.697 · Cited by 24 · see citing works
Electroactive polyacrylamide/chitosan/polypyrrole hydrogel for captopril release controlled by electricity
Ovando‐Medina, V. M., Reyes‐Palacios, G. A., García‐Montejano, L. A., Antonio-Carmona, I. D., & Martínez‐Gutiérrez, H. (2021) · Journal of Vinyl and Additive Technology · doi:10.1002/vnl.21842 · Cited by 24 · see citing works
Pathophysiology of Hypertension
Hall, J. E., Omoto, A. C. M., Wang, Z., Mouton, A. J., Li, X., & Hall, M. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-88369-6.00005-0 · Cited by 31 · see citing works
Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
Cavalcanti, C. D. O., Alves, R. R., de Oliveira, A. L., Cruz, J. C., de França-Silva, M. D. S., Braga, V. A., & Balarini, C. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00015 · Cited by 24 · see citing works
A neural blood pressure marker for bioelectronic medicines for treatment of hypertension
Sevcencu, C., Nielsen, T. N., & Struijk, J. J. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.06.031 · Cited by 24 · see citing works
Can C-Reactive Protein to Albumin Ratio Predict In-Hospital Death Rate Due to COVID-19 in Patients With Hypertension?
Şaylık, F., Akbulut, T., & Kaya, Ş. (2021) · Angiology · doi:10.1177/00033197211012145 · Cited by 23 · see citing works
Positive Effect of a Pea–Clam Two-Peptide Composite on Hypertension and Organ Protection in Spontaneously Hypertensive Rats
Sun, X., Wang, M., Xu, C., Wang, S., Li, L., Zou, S., Yu, J., & Wei, Y. (2022) · Nutrients · doi:10.3390/nu14194069 · Cited by 23 · see citing works
Chronic Treatment With Acetylcholinesterase Inhibitors Attenuates Vascular Dysfunction in Spontaneously Hypertensive Rats
Lataro, R. M., Silva, M. A. B., Mestriner, F., Cáu, S. B. D. A., Tostes, R. C., & Salgado, H. C. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz036 · Cited by 23 · see citing works
Antihypertensive effect of carvacrol is improved after incorporation in β‐cyclodextrin as a drug delivery system
da Silva, L. B., Camargo, S. B., Moraes, R. D. A., Medeiros, C. F. D. A., Jesus, A. D. M., Evangelista, A. F., Villarreal, C. F., Quintans‐Júnior, L. J., & Silva, D. F. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13364 · Cited by 23 · see citing works
Recent Advances in Therapeutic Vaccines to Treat Hypertension
Nakagami, H., & Morishita, R. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11084 · Cited by 22 · see citing works
High-mobility group box 1 protein, angiotensins, ACE2, and target organ damage
Luft, F. C. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1372-1 · Cited by 22 · see citing works
A Primer to Angiotensin Peptide Isolation, Stability, and Analysis by Nano-Liquid Chromatography with Mass Detection
Olkowicz, M., Chłopicki, S., & Smolenski, R. T. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7030-8_14 · Cited by 21 · see citing works
Sensory signals mediating high blood pressure via sympathetic activation: role of adipose afferent reflex
Dalmasso, C., Leachman, J. R., Osborn, J. L., & Loria, A. S. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00079.2019 · Cited by 21 · see citing works
Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction
Jiang, W., Chen, C., Huo, J., Lu, D., Jiang, Z., Geng, J., Xu, H., & Shan, Q. (2018) · Scientific Reports · doi:10.1038/s41598-018-28562-z · Cited by 21 · see citing works
Approaches for the Management of Resistant Hypertension in 2020
Aronow, W. S. (2020) · Current Hypertension Reports · doi:10.1007/s11906-019-1013-0 · Cited by 21 · see citing works
Short-term outcome and early effect on blood pressure of laparoscopic sleeve gastrectomy in morbidly obese patients
Yin, X., Qian, J., Wang, Y., Yang, C., Jia, B., Cheng, Y., Yu, G., & Wang, Y. (2018) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2018.1529775 · Cited by 20 · see citing works
Erratum to: Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19: European Society of Hypertension COVID-19 Task Force Review of Evidence
Kreutz, R. H., Algharably, E. A. E., Azizi, M., Dobrowolski, P., Guzik, T. J., Januszewicz, A., Persu, A., Prejbisz, A., Riemer, T., Wang, J., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab224 · Cited by 20 · see citing works
Targeting cytokine-like protein FAM3D lowers blood pressure in hypertension
Shen, Y., Dong, Z., Fan, F., Li, K., Zhu, S., Dai, R., Huang, J., Xie, N., He, L., Gong, Z., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101072 · Cited by 19 · see citing works
Does Aldosterone Play a Significant Role for Regulation of Vascular Tone?
Lyngsø, K. S., Assersen, K. B., Dalgaard, E. G., Skøtt, O., Jensen, B. L., & Hansen, P. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000345 · Cited by 19 · see citing works
Noninvasive Stereotactic Radiotherapy for Renal Denervation in a Swine Model
Cai, X., Yang, Y., Shen, Y., Wang, W., Qian, L., Cai, J., Chi, R., Fei, Y., Yu, S., Wei, L., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.053 · Cited by 19 · see citing works
Managing Hypertension in the elderly: What’s new?
Aronow, W. S. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100001 · Cited by 19 · see citing works
Introduction to a Compendium on Hypertension
Mancia, G. (2015) · Circulation Research · doi:10.1161/circresaha.115.305755 · Cited by 19 · see citing works

Authors: Oparil, S., & Schmieder, R. E.
Affiliations: University of Alabama at Birmingham Hospital (US)
ORCID: Oparil, Suzanne
Schmieder, Roland E.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-03-13
Volume: 116
Issue: 6
Pages: 1074-1095
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.116.303603
OpenAlex: W2138173257
Cited by: 276
References: 213
Citations by year: 2026: 10 · 2025: 14 · 2024: 20 · 2023: 26 · 2022: 23 · 2021: 27 · 2020: 30 · 2019: 33 · 2018: 26 · 2017: 29 · 2016: 24 · 2015: 14
FWCI: 22.79
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: hypertension, antihypertensive drugs, treatment-resistant hypertension, vasopeptidase inhibitors, aldosterone synthase inhibitors, soluble epoxide hydrolase inhibitors, mineralocorticoid receptor antagonists, dopamine beta-hydroxylase inhibitor, Na+/H+ exchanger 3, baroreflex activation therapy, arteriovenous fistula, cardiovascular disease prevention, uncontrolled hypertension
MeSH terms: Mineralocorticoid Receptor Antagonists, Animals, Antihypertensive Agents, Arteriovenous Shunt, Surgical, Carotid Body, Clinical Trials as Topic, Electric Stimulation Therapy, Enzyme Inhibitors, Female, Humans, Hypertension, Ion Channels, Kidney, Kidney Tubules, Pre-Eclampsia, Pregnancy, Pressoreceptors, Receptors, Cell Surface, Renal Artery, Renin-Angiotensin System, Sympathectomy, Sympathetic Nervous System, Drug Design, Multicenter Studies as Topic, Drugs, Investigational, Stents, Comorbidity, Randomized Controlled Trials as Topic, Baroreflex, Oxidative Stress, Decompression, Surgical, Models, Animal, Therapies, Investigational, High-Intensity Focused Ultrasound Ablation, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New approaches in the treatment of hypertension

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks