Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

Villaret, Aurélie; Galitzky, Jean; Decaunes, Pauline; Estève, David; Marques, Marie-Adeline; Sengenès, Coralie; Chiotasso, Patrick; Tchkonia, Tamara; Lafontan, Max; Kirkland, James L.; Bouloumié, Anne

doi:10.2337/db10-0398

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage, susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We defined the properties of endothelial cells (EC) isolated from subcutaneous adipose tissue (SAT) and visceral adi…