From Blood Monocytes to Adipose Tissue-Resident Macrophages
Open accessAbstract
Obesity has been suggested to be a low-grade systemic inflammatory state, therefore we studied the interaction between human adipocytes and monocytes via adipose tissue (AT)-derived capillary endothelium. Cells composing the stroma-vascular fraction (SVF) of human ATs were characterized by fluorescence-activated cell sorter (FACS) analysis and two cell subsets (resident macrophages and endothelial cells [ECs]) were isolated using antibody-coupled microbeads. Media conditioned by mature adipocytes maintained in fibrin gels were applied to AT-derived ECs. Thereafter, the expression of endothelial adhesion molecules was analyzed as well as the adhesion and transmigration of human monocytes. FACS analysis showed that 11% of the SVF is composed of CD14+/CD31+ cells, characterized as resident macrophages. A positive correlation was found between the BMI and the percentage of resident macrophages, suggesting that fat tissue growth is associated with a recruitment of blood monocytes. Incubation of AT-derived ECs with adipocyte-conditioned medium resulted in the upregulation of EC adhesion molecules and the increased chemotaxis of blood monocytes, an effect mimicked by recombinant human leptin. These results indicate that adipokines, such as leptin, activate ECs, leading to an enhanced diapedesis of blood monocytes, and suggesting that fat mass growth might be linked to inflammatory processes.
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The non-adipose stroma vascular fraction (SVF) of WAT, comprising infiltrated macrophages among other cellular types, is a source of inflammation-related molecules that may exert a local action on adipose tissue biology, particularly within the enlarged WAT.
“Although some molecules secreted by WAT, such as leptin and adiponectin, are synthesized by mature adipocytes [8], the non-adipose SVF, comprising infiltrated macrophages among other cellular types, is a source of inflammation-related molecules that may exert a local action on adipose tissue biology, particularly within the enlarged WAT [9-11].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [10]
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- Authors
- Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A.
- Affiliations
- Goethe University Frankfurt (DE)
- Department of Cardiovascular Physiology, J.W. Goethe University, Frankfurt am Main, Germany
- Sana Klinikum Offenbach (DE)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2004-05-01
- Volume
- 53
- Issue
- 5
- Pages
- 1285-1292
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2106919150
- Cited by
- 600
- References
- 33
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 16 · 2022: 20 · 2021: 13 · 2020: 11 · 2019: 20 · 2018: 18 · 2017: 32 · 2016: 18 · 2015: 33 · 2014: 25 · 2013: 48 · 2012: 44
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adipose tissue macrophages, blood monocytes, obesity, low-grade inflammation, adipocytes, endothelial cells, stromal vascular fraction, leptin, adipokines, monocyte transmigration, endothelial adhesion molecules, chemotaxis, monocyte recruitment, body mass index
- MeSH terms
- Adipose Tissue, Capillaries, Cell Adhesion, Cell Movement, Cells, Cultured, Endothelium, Vascular, Humans, Macrophages, Monocytes, Cellular Senescence, Culture Media, Conditioned, Adipocytes
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