Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity
Open accessAbstract
In human obesity, white adipose tissue (WAT) is enriched in macrophages. How macrophage infiltration in WAT contributes to the complications of obesity is unknown. This study tested the hypothesis that recruitment of macrophages in omental WAT is associated with hepatic damage in obese patients. Paired biopsies of subcutaneous and omental WAT and a liver biopsy were collected during gastric surgery in 46 obese women and 9 obese men (BMI 47.9 ± 0.93 kg/m2). The number of HAM56+ macrophages in WAT was quantified microscopically, and correlations with clinical and biological parameters and histological liver pathology were investigated. There were twice as many macrophages in omental as in subcutaneous WAT (P < 0.0001). After adjustment for age, omental WAT macrophage infiltration was correlated to fasting glucose and insulin, quantitative insulin sensitivity check index, triglycerides, aspartate aminotransferase (AST), and γ-glutamyltranspeptidase. We propose an easy equation to estimate the amount of macrophages in omental WAT. Increased macrophage accumulation specifically in omental WAT was associated with hepatic fibroinflammatory lesions (P = 0.01). The best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and omental WAT macrophages. These data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients.
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Advanced glycation end products may also be derived from food or tobacco.
“AGE may also be derived from food (454,461) or tobacco (462) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [462]
Weight reduction regimens result in a lowering of inflammatory markers, suggesting that macrophage infiltration is reversible.
“Conversely, weight reduction regimens resulted in a lowering of inflammatory markers, which suggested that this infiltration is reversible (7).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [7]
Obese subjects harbor increased adipose tissue macrophage content, particularly in more insulin-resistant visceral depots.
“In parallel, obese subjects were found to harbor increased AT macrophage (ATMΦ) content, particularly in more insulin-resistant visceral depots (7).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [7]
We confirmed the significant presence of macrophage cells in human WAT.
“Among them, we confirmed the significant presence of macrophage cells in human WAT [46].”
From Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity (2008) · cites this paper as [46]
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- Authors
- Cancello, R., Tordjman, J., Poitou, C., Guilhem, G., Bouillot, J. L., Hugol, D., Coussieu, C., Basdevant, A., Hen, A. B., Bedossa, P., Guerre-Millo, M., & Clément, K.
- Affiliations
- Inserm (FR)
- Institut National de la Santé et de la Recherche Médicale (INSERM), U755 Nutriomique, Paris, France
- Assistance Publique – Hôpitaux de Paris (FR)
- LIM and BIO, Paris 13 University, Bobigny, France
- Pathology Department, AP-HP Beaujon Hospital, Clichy France
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2006-06-01
- Volume
- 55
- Issue
- 6
- Pages
- 1554-1561
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2134133526
- Cited by
- 607
- References
- 37
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 21 · 2023: 20 · 2022: 28 · 2021: 28 · 2020: 35 · 2019: 21 · 2018: 38 · 2017: 37 · 2016: 28 · 2015: 33 · 2014: 39 · 2013: 46 · 2012: 40
- FWCI
- 24.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- macrophage infiltration, omental adipose tissue, subcutaneous adipose tissue, morbid obesity, liver injury, insulin resistance, aspartate aminotransferase, gamma-glutamyltranspeptidase, obesity-related liver disease
- MeSH terms
- Adult, Analysis of Variance, Aspartate Aminotransferases, Blood Glucose, Female, gamma-Glutamyltransferase, Humans, Immunohistochemistry, Insulin, Cholesterol, HDL, Liver, Macrophages, Male, Obesity, Morbid, Omentum, Triglycerides, Linear Models, Adipocytes, Subcutaneous Fat, Adipose Tissue, White
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