Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 156

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase

Martínez de Morentin, Pablo B., Whittle, Andrew J., Fernø, Johan, Nogueiras, Rubén, Diéguez, Carlos, Vidal-Puig, Antonio, López, Miguel·2012·Diabetes
DOI 10.2337/db11-1079
Open this paper in CoChat — free account

Abstract

Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action. The effects of nicotine on energy homeostasis have been mostly pinpointed in the central nervous system, but the molecular mechanisms controlling its action are still not fully understood. The aim of this study was to investigate the effect of nicotine on hypothalamic AMP-activated protein kinase (AMPK) and its effect on energy balance. Here we demonstrate that nicotine-induced weight loss is associated with inactivation of hypothalamic AMPK, decreased orexigenic signaling in the hypothalamus, increased energy expenditure as a result of increased locomotor activity, increased thermogenesis in brown adipose tissue (BAT), and alterations in fuel substrate utilization. Conversely, nicotine withdrawal or genetic activation of hypothalamic AMPK in the ventromedial nucleus of the hypothalamus reversed nicotine-induced negative energy balance. Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2337/db11-1079

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Research works printed but not linked: 40

  1. Grunberg, 2007, A neurobiological basis for nicotine withdrawal, Proc Natl Acad Sci USA, 104, 17901, 10.1073/pnas.0708964104 · DOI
  2. Mineur, 2011, Nicotine decreases food intake through activation of POMC neurons, Science, 332, 1330, 10.1126/science.1201889 · DOI · Paper page
  3. Seeley, 2011, Neuroscience: weight loss through smoking, Nature, 475, 176, 10.1038/475176a · DOI
  4. Elmquist, 2005, Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis, J Comp Neurol, 493, 63, 10.1002/cne.20786 · DOI
  5. Xue, 2009, Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues, Mol Cell Biol, 29, 4563, 10.1128/MCB.01914-08 · DOI
  6. López, 2010, Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance, Nat Med, 16, 1001, 10.1038/nm.2207 · DOI
  7. Fliers, 2010, Novel neural pathways for metabolic effects of thyroid hormone, Trends Endocrinol Metab, 21, 230, 10.1016/j.tem.2009.11.008 · DOI
  8. Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab, 1, 15, 10.1016/j.cmet.2004.12.003 · DOI · Paper page
  9. Lage, 2008, AMPK: a metabolic gauge regulating whole-body energy homeostasis, Trends Mol Med, 14, 539, 10.1016/j.molmed.2008.09.007 · DOI
  10. Minokoshi, 2004, AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus, Nature, 428, 569, 10.1038/nature02440 · DOI · Paper page
  11. López, 2008, Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin, Cell Metab, 7, 389, 10.1016/j.cmet.2008.03.006 · DOI
  12. Jang, 2003, Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats, Brain Res, 964, 311, 10.1016/S0006-8993(02)04122-7 · DOI
  13. Bishop, 2002, Nicotine and its withdrawal alter feeding induced by paraventricular hypothalamic injections of neuropeptide Y in Sprague-Dawley rats, Psychopharmacology (Berl), 162, 265, 10.1007/s00213-002-1101-7 · DOI
  14. Fornari, 2007, Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice, Neurosci Lett, 411, 72, 10.1016/j.neulet.2006.10.014 · DOI · Paper page
  15. Hur, 2010, High fat diet altered the mechanism of energy homeostasis induced by nicotine and withdrawal in C57BL/6 mice, Mol Cells, 30, 219, 10.1007/s10059-010-0110-3 · DOI
  16. Arai, 2001, Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats, Am J Physiol Endocrinol Metab, 280, E867, 10.1152/ajpendo.2001.280.6.E867 · DOI · Paper page
  17. Mano-Otagiri, 2009, Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor, Neurosci Lett, 455, 26, 10.1016/j.neulet.2009.03.054 · DOI
  18. Li, 2000, Nicotine administration enhances NPY expression in the rat hypothalamus, Brain Res, 867, 157, 10.1016/S0006-8993(00)02283-6 · DOI
  19. López, 2006, Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA, Diabetes, 55, 1327, 10.2337/db05-1356 · DOI
  20. Paxinos, 1986, The rat brain in stereotaxic coordinates
  21. Theander-Carrillo, 2006, Ghrelin action in the brain controls adipocyte metabolism, J Clin Invest, 116, 1983, 10.1172/JCI25811 · DOI · Paper page
  22. Sloan, 1989, Mechanisms involved in the respiratory depressant actions of nicotine in anesthetized rats, Pharmacol Biochem Behav, 34, 559, 10.1016/0091-3057(89)90558-3 · DOI
  23. Aberger, 2001, Cardiovascular responses to microinjections of nicotine into the caudal ventrolateral medulla of the rat, Brain Res, 892, 138, 10.1016/S0006-8993(00)03250-9 · DOI
  24. Dickson, 2010, Blockade of central nicotine acetylcholine receptor signaling attenuate ghrelin-induced food intake in rodents, Neuroscience, 171, 1180, 10.1016/j.neuroscience.2010.10.005 · DOI
  25. Farooqi, 2005, Monogenic obesity in humans, Annu Rev Med, 56, 443, 10.1146/annurev.med.56.062904.144924 · DOI
  26. Ropelle, 2010, IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition, PLoS Biol, 8, e1000465, 10.1371/journal.pbio.1000465 · DOI · Paper page
  27. Foster-Schubert, 2006, Emerging therapeutic strategies for obesity, Endocr Rev, 27, 779, 10.1210/er.2006-0041 · DOI
  28. Hampl, 1999, Cigarette use during adolescence: effects on nutritional status, Nutr Rev, 57, 215, 10.1111/j.1753-4887.1999.tb06945.x · DOI
  29. Bize, 2010, Participation in a population-based physical activity programme as an aid for smoking cessation: a randomised trial, Tob Control, 19, 488, 10.1136/tc.2009.030288 · DOI
  30. Gross, 1989, Nicotine replacement: effects of postcessation weight gain, J Consult Clin Psychol, 57, 87, 10.1037/0022-006X.57.1.87 · DOI
  31. Yoshida, 1999, Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice, Int J Obes Relat Metab Disord, 23, 570, 10.1038/sj.ijo.0800870 · DOI · Paper page
  32. Frankish, 1995, Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus: NPY may mediate nicotine’s effects on energy balance, Brain Res, 694, 139, 10.1016/0006-8993(95)00834-D · DOI
  33. Chen, 2007, Regulation of hypothalamic NPY by diet and smoking, Peptides, 28, 384, 10.1016/j.peptides.2006.07.034 · DOI
  34. Cannon, 2010, Thyroid hormones: igniting brown fat via the brain, Nat Med, 16, 965, 10.1038/nm0910-965 · DOI
  35. Niijima, 1984, Role of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue, Am J Physiol, 247, R650
  36. Nedergaard, 2007, Unexpected evidence for active brown adipose tissue in adult humans, Am J Physiol Endocrinol Metab, 293, E444, 10.1152/ajpendo.00691.2006 · DOI · Paper page
  37. Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N Engl J Med, 360, 1509, 10.1056/NEJMoa0810780 · DOI · Paper page
  38. Hofstetter, 1986, Increased 24-hour energy expenditure in cigarette smokers, N Engl J Med, 314, 79, 10.1056/NEJM198601093140204 · DOI
  39. Newhouse, 2004, Effects of nicotinic stimulation on cognitive performance, Curr Opin Pharmacol, 4, 36, 10.1016/j.coph.2003.11.001 · DOI
  40. Thacker, 2007, Temporal relationship between cigarette smoking and risk of Parkinson disease, Neurology, 68, 764, 10.1212/01.wnl.0000256374.50227.4b · DOI

Cited by

See all 156

Metadata

Authors
Martínez de Morentin, P. B., Whittle, A. J., Fernø, J., Nogueiras, R., Diéguez, C., Vidal-Puig, A., & López, M.
Affiliations
  • Department of Physiology, School of Medicine-CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruña, Spain
  • Institute of Metabolic Science, Metabolic Research Laboratories, NIHR Cambridge Biomedical Research Centre Addenbrooke's Hospital, University of Cambridge, Cambridge, U.K.
  • Dr. Einar Martens’ Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway
Venue
Diabetes
Publisher
American Diabetes Association
Published
2012-03-14
Volume
61
Issue
4
Pages
807-817
ISSN
  • 0012-1797
  • 1939-327X
DOI
10.2337/db11-1079
Cited by
156
References
10
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 3453 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase. https://app.cochat.ai/papers/10.2337/db11-1079
The paper
Martínez de Morentin, P. B., Whittle, A. J., Fernø, J., Nogueiras, R., Diéguez, C., Vidal-Puig, A., & López, M. (2012). Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase. Diabetes. https://doi.org/10.2337/db11-1079

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.