The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Novel and Reversible Mechanisms of Smoking-Induced Insulin Resistance in Humans
Open accessAbstract
Smoking is the most common cause of preventable morbidity and mortality in the United States, in part because it is an independent risk factor for the development of insulin resistance and type 2 diabetes. However, mechanisms responsible for smoking-induced insulin resistance are unclear. In this study, we found smokers were less insulin sensitive compared with controls, which increased after either 1 or 2 weeks of smoking cessation. Improvements in insulin sensitivity after smoking cessation occurred with normalization of IRS-1ser636 phosphorylation. In muscle cell culture, nicotine exposure significantly increased IRS-1ser636 phosphorylation and decreased insulin sensitivity, recapitulating the phenotype of smoking-induced insulin resistance in humans. The two pathways known to stimulate IRS-1ser636 phosphorylation (p44/42 mitogen-activated protein kinase [MAPK] and mammalian target of rapamycin [mTOR]) were both stimulated by nicotine in culture. Inhibition of mTOR, but not p44/42 MAPK, during nicotine exposure prevented IRS-1ser636 phosphorylation and normalized insulin sensitivity. These data indicate nicotine induces insulin resistance in skeletal muscle by activating mTOR. Therapeutic agents designed to oppose skeletal muscle mTOR activation may prevent insulin resistance in humans who are unable to stop smoking or are chronically exposed to secondhand smoke.
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Cites
Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Diet, muscle glycogen and physical performance.
Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740 · cited 5×
“IMTG FSR and IMTG and DAG saturation were calculated as previously described (17).”
MethodInfluentialMammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking
Barnoya, J., & Glantz, S. A. (2005) · Circulation · doi:10.1161/circulationaha.104.492215 · Cited by 939 · cited 1×
“Carrying an almost equal risk as active smoking for the development of cardiovascular disease is exposure to secondhand smoke (6).”
BackgroundPositive and negative regulation of insulin signaling through IRS-1 phosphorylation
Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · cited 1×
“Serine phosphorylation of many sites on IRS-1, including ser636, decreases IRS-1 tyrosine phosphorylation, phosphatidylinositol-3-kinase binding, and insulin-stimulated glucose uptake (39).”
BackgroundMorino, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25151 · Cited by 811
Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M. (1983) · Muscle & Nerve · doi:10.1002/mus.880060809 · Cited by 582
Perry, I. J., Wannamethee, S. G., Walker, M. K., Thomson, A. G., Whincup, P. H., & Shaper, A. G. (1995) · BMJ · doi:10.1136/bmj.310.6979.560 · Cited by 532
Cited by
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939
Henderson, D. C., Vincenzi, B., Andrea, N. V., Ulloa, M., & Copeland, P. M. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00115-7 · Cited by 288
Xia, J., Wang, L., Ma, Z., Zhong, L., Wang, Y., Gao, Y., He, L., & Su, X. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw452 · Cited by 285
Early life factors and type 2 diabetes mellitus
Jiang, X., Ma, H., Wang, Y., & Liu, Y. (2013) · Journal of Diabetes Research · doi:10.1155/2013/485082 · Cited by 92
Carlsson, S., Andersson, T., Araghi, M., Galanti, R., Lager, A., Lundberg, M., Nilsson, P., Norberg, M., Pedersen, N. L., Trolle‐Lagerros, Y., et al. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12592 · Cited by 68
Metadata
- Authors
- Bergman, B. C., Perreault, L., Hunerdosse, D., Kerege, A., Playdon, M., Samek, A. M., & Eckel, R. H.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2012-11-15
- Volume
- 61
- Issue
- 12
- Pages
- 3156-3166
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2168247614
- Cited by
- 167
- References
- 17
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bergman, B. C., Perreault, L., Hunerdosse, D., Kerege, A., Playdon, M., Samek, A. M., & Eckel, R. H. (2012). Novel and Reversible Mechanisms of Smoking-Induced Insulin Resistance in Humans. Diabetes. https://doi.org/10.2337/db12-0418
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