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Cited by 59

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Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized 13C Dehydroascorbate Magnetic Resonance

Keshari, Kayvan R., Wilson, David M., Sai, Victor, Bok, Robert, Jen, Kuang-Yu, Larson, Peder, Van Criekinge, Mark, Kurhanewicz, John, Wang, Zhen J.·2015·Diabetes
DOI 10.2337/db13-1829PMC PMC4303960
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Abstract

Oxidative stress has been proposed to be a unifying cause for diabetic nephropathy and a target for novel therapies. Here we apply a new endogenous reduction-oxidation (redox) sensor, hyperpolarized (HP) 13C dehydroascorbate (DHA), in conjunction with MRI to noninvasively interrogate the renal redox capacity in a mouse diabetes model. The diabetic mice demonstrate an early decrease in renal redox capacity, as shown by the lower in vivo HP 13C DHA reduction to the antioxidant vitamin C (VitC), prior to histological evidence of nephropathy. This correlates with lower tissue reduced glutathione (GSH) concentration and higher NADPH oxidase 4 (Nox4) expression, consistent with increased superoxide generation and oxidative stress. ACE inhibition restores the HP 13C DHA reduction to VitC with concomitant normalization of GSH concentration and Nox4 expression in diabetic mice. HP 13C DHA enables rapid in vivo assessment of altered redox capacity in diabetic renal injury and after successful treatment.

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Research works printed but not linked: 47

  1. Caramori, 2003, Diabetes and nephropathy, Curr Opin Nephrol Hypertens, 12, 273, 10.1097/00041552-200305000-00008 · DOI
  2. Rösen, 2001, The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society, Diabetes Metab Res Rev, 17, 189, 10.1002/dmrr.196 · DOI
  3. Nishikawa, 2000, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature, 404, 787, 10.1038/35008121 · DOI · Paper page
  4. Forbes, 2008, Oxidative stress as a major culprit in kidney disease in diabetes, Diabetes, 57, 1446, 10.2337/db08-0057 · DOI · Paper page
  5. Brownlee, 2005, The pathobiology of diabetic complications: a unifying mechanism, Diabetes, 54, 1615, 10.2337/diabetes.54.6.1615 · DOI · Paper page
  6. Gorin, 2005, Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney, J Biol Chem, 280, 39616, 10.1074/jbc.M502412200 · DOI
  7. Block, 2009, Subcellular localization of Nox4 and regulation in diabetes, Proc Natl Acad Sci U S A, 106, 14385, 10.1073/pnas.0906805106 · DOI
  8. Sedeek, 2010, Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy, Am J Physiol Renal Physiol, 299, F1348, 10.1152/ajprenal.00028.2010 · DOI · Paper page
  9. Gorin, 2013, Nox4 and diabetic nephropathy: with a friend like this, who needs enemies, Free Radic Biol Med, 61C, 130, 10.1016/j.freeradbiomed.2013.03.014 · DOI
  10. Gorin, 2013, Nox as a target for diabetic complications, Clin Sci (Lond), 125, 361, 10.1042/CS20130065 · DOI
  11. Thallas-Bonke, 2008, Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway, Diabetes, 57, 460, 10.2337/db07-1119 · DOI
  12. Fujii, 2007, Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice, Kidney Int, 72, 473, 10.1038/sj.ki.5002366 · DOI
  13. Singh, 2011, Oxidative stress in early diabetic nephropathy: fueling the fire, Nat Rev Endocrinol, 7, 176, 10.1038/nrendo.2010.212 · DOI
  14. Kanwar, 2011, A glimpse of various pathogenetic mechanisms of diabetic nephropathy, Annu Rev Pathol, 6, 395, 10.1146/annurev.pathol.4.110807.092150 · DOI
  15. Sato-Horiguchi, 2012, Telmisartan attenuates diabetic nephropathy by suppressing oxidative stress in db/db mice, Nephron Exp Nephrol, 121, e97, 10.1159/000343102 · DOI
  16. Kim, 2012, Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells, PLoS One, 7, e39739, 10.1371/journal.pone.0039739 · DOI
  17. Keshari, 2014, The chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization, Chem Soc Rev, 43, 1627, 10.1039/C3CS60124B · DOI
  18. Ardenkjaer-Larsen, 2003, Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR, Proc Natl Acad Sci U S A, 100, 10158, 10.1073/pnas.1733835100 · DOI
  19. Keshari, 2011, Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging, Proc Natl Acad Sci U S A, 108, 18606, 10.1073/pnas.1106920108 · DOI
  20. Liang, 2001, Vitamin C transport systems of mammalian cells, Mol Membr Biol, 18, 87, 10.1080/09687680110033774 · DOI · Paper page
  21. Ghiselli, 2000, Total antioxidant capacity as a tool to assess redox status: critical view and experimental data, Free Radic Biol Med, 29, 1106, 10.1016/S0891-5849(00)00394-4 · DOI
  22. Keshari, 2013, Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET, J Nucl Med, 54, 922, 10.2967/jnumed.112.115402 · DOI
  23. Cohen, 2001, Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice, Metabolism, 50, 1435, 10.1053/meta.2001.28074 · DOI
  24. Sharma, 2003, Diabetic kidney disease in the db/db mouse, Am J Physiol Renal Physiol, 284, F1138, 10.1152/ajprenal.00315.2002 · DOI
  25. Rahman, 2006, Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method, Nat Protoc, 1, 3159, 10.1038/nprot.2006.378 · DOI
  26. Gabriely, 2001, Hyperglycemia modulates angiotensinogen gene expression, Am J Physiol Regul Integr Comp Physiol, 281, R795, 10.1152/ajpregu.2001.281.3.R795 · DOI
  27. Catherwood, 2002, Glucose-induced oxidative stress in mesangial cells, Kidney Int, 61, 599, 10.1046/j.1523-1755.2002.00168.x · DOI
  28. Ozdemir, 2005, Malondialdehyde, glutathione, glutathione peroxidase and homocysteine levels in type 2 diabetic patients with and without microalbuminuria, Ann Clin Biochem, 42, 99, 10.1258/0004563053492838 · DOI
  29. Koya, 2003, Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats, J Am Soc Nephrol, 14, S250, 10.1097/01.ASN.0000077412.07578.44 · DOI
  30. Beisswenger, 2005, Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress, Diabetes, 54, 3274, 10.2337/diabetes.54.11.3274 · DOI
  31. Griendling, 1994, Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells, Circ Res, 74, 1141, 10.1161/01.RES.74.6.1141 · DOI · Paper page
  32. Forbes, 2002, Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy, Diabetes, 51, 3274, 10.2337/diabetes.51.11.3274 · DOI
  33. Yoshida, 2009, Urinary oxidative stress markers closely reflect the efficacy of candesartan treatment for diabetic nephropathy, Nephron Exp Nephrol, 111, e20, 10.1159/000178764 · DOI
  34. Shah, 2007, Oxidants in chronic kidney disease, J Am Soc Nephrol, 18, 16, 10.1681/ASN.2006050500 · DOI
  35. Hsu, 2010, N-acetylcysteine for the management of anemia and oxidative stress in hemodialysis patients, Nephron Clin Pract, 116, c207, 10.1159/000317201 · DOI
  36. Siushansian, 1997, Cerebral astrocytes transport ascorbic acid and dehydroascorbic acid through distinct mechanisms regulated by cyclic AMP, J Neurochem, 68, 2378, 10.1046/j.1471-4159.1997.68062378.x · DOI
  37. Qutob, 1998, Insulin stimulates vitamin C recycling and ascorbate accumulation in osteoblastic cells, Endocrinology, 139, 51, 10.1210/endo.139.1.5659 · DOI
  38. Vera, 1998, Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells, Blood, 91, 2536, 10.1182/blood.V91.7.2536 · DOI
  39. Park, 2001, Reduction of dehydroascorbic acid by homocysteine, Biochim Biophys Acta, 1525, 173, 10.1016/S0304-4165(00)00186-0 · DOI
  40. Wells, 1990, Mammalian thioltransferase (glutaredoxin) and protein disulfide isomerase have dehydroascorbate reductase activity, J Biol Chem, 265, 15361, 10.1016/S0021-9258(18)55401-6 · DOI
  41. Whitbread, 2005, Characterization of the omega class of glutathione transferases, Methods Enzymol, 401, 78, 10.1016/S0076-6879(05)01005-0 · DOI
  42. Broedbaek, 2011, Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients, Diabetes Care, 34, 2594, 10.2337/dc11-1620 · DOI
  43. Morrow, 1991, Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress, Free Radic Biol Med, 10, 195, 10.1016/0891-5849(91)90076-F · DOI
  44. Sonta, 2005, In vivo imaging of oxidative stress in the kidney of diabetic mice and its normalization by angiotensin II type 1 receptor blocker, Biochem Biophys Res Commun, 330, 415, 10.1016/j.bbrc.2005.02.174 · DOI
  45. Han, 2010, In vivo electron spin resonance: an effective new tool for reactive oxygen species/reactive nitrogen species measurement, Arch Pharm Res, 33, 1293, 10.1007/s12272-010-0901-2 · DOI
  46. Towner, 2012, In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model, Diabetes, 61, 2405, 10.2337/db11-1540 · DOI
  47. Nelson, 2013, Metabolic imaging of patients with prostate cancer using hyperpolarized [1-13C]pyruvate, Sci Transl Med, 5, 198ra108, 10.1126/scitranslmed.3006070 · DOI

Cited by

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Metadata

Authors
Keshari, K. R., Wilson, D. M., Sai, V., Bok, R., Jen, K.-Y., Larson, P., Van Criekinge, M., Kurhanewicz, J., & Wang, Z. J.
Venue
Diabetes
Publisher
American Diabetes Association
Published
2014-09-02
Volume
64
Issue
2
Pages
344-352
ISSN
  • 0012-1797
  • 1939-327X
DOI
10.2337/db13-1829
PMC
PMC4303960
Cited by
59
References
2
Language
en
Licence
www.diabetesjournals.org/site/license (vor, 333 d)
Funders
Institut national de la santè et de la recherche mèdicale (P41EB013598, R00EB012064, R00EB014328, R01CA166766)

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