Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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Metabolic syndrome: from epidemiology to systems biology

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Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

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Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

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FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression

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Hepatoprotective role of Sestrin2 against chronic ER stress

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ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated Phosphorylation of Rictor

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Nelfinavir and bortezomib inhibit mTOR activity via ATF4‐mediated sestrin‐2 regulation

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Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

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Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

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Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes

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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

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Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

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Sestrins are evolutionarily conserved mediators of exercise benefits

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mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target

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Sestrins in Physiological Stress Responses

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Sestrin 3 Protects Against Diet‐Induced Nonalcoholic Steatohepatitis in Mice Through Suppression of Transforming Growth Factor β Signal Transduction

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The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

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Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer

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Sestrin2 as a Potential Target for Regulating Metabolic-Related Diseases

Gong, L., Wang, Z., Wang, Z., & Zhang, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751020 · Cited by 49 · see citing works

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle

Zeng, N., D’Souza, R. F., Figueiredo, V. C., Markworth, J. F., Roberts, L. A., Peake, J. M., Mitchell, C. J., & Cameron‐Smith, D. (2017) · Physiological Reports · doi:10.14814/phy2.13526 · Cited by 47 · see citing works

Sestrin2 regulates monocyte activation through AMPK‐mTOR nexus under high‐glucose and dyslipidemic conditions

Sundararajan, S., Jayachandran, I., Balasubramanyam, M., Mohan, V., Venkatesan, B. A., & Manickam, N. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28102 · Cited by 46 · see citing works

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

Parmigiani, A., & Budanov, A. V. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.003 · Cited by 38 · see citing works

Sestrin family – the stem controlling healthy ageing

Haidurov, A., & Budanov, A. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111379 · Cited by 35 · see citing works

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Ro, S., Fay, J., Cyuzuzo, C. I., Jang, Y., Lee, N., Song, H., & Harris, E. N. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603421 · Cited by 34 · see citing works

Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation

Dong, Z., Lin, C., Liu, Y., Jin, H., Wu, H., Li, Z., Sun, L., Zhang, L., Hu, X., Wei, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep46307 · Cited by 32 · see citing works

Decreased Sestrin levels in patients with type 2 diabetes and dyslipidemia and their association with the severity of atherogenic index

Sundararajan, S., Jayachandran, I., Subramanian, S. C., Anjana, R. M., Balasubramanyam, M., Mohan, V., Venkatesan, B. A., & Manickam, N. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01429-9 · Cited by 31 · see citing works

Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway

Liu, Y., Kim, H.-G., Dong, E., Dong, C., Huang, M., Liu, Y., Liangpunsakul, S., & Dong, X. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.07.011 · Cited by 30 · see citing works

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells

Khan, N., Jajeh, F., Khan, M. I., Mukhtar, E., Shabana, S. M., & Mukhtar, H. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw124 · Cited by 29 · see citing works

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins

Wang, T., Niu, Y., Liu, S., Yuan, H., Liu, X., & Fu, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.023 · Cited by 29 · see citing works

Substrate metabolism regulated by Sestrin2–mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart

Quan, N., Li, X., Zhang, J., Han, Y., Sun, W., Ren, D., Tong, Q., & Li, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101637 · Cited by 29 · see citing works

Protective response of Sestrin under stressful conditions in aging

Rai, N., & Dey, S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101186 · Cited by 28 · see citing works

p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis

Ding, B., Haidurov, A., Chawla, A. T., Parmigiani, A., van de Kamp, G., Dalina, A. A., Yuan, F., Lee, J. H., Chumakov, P. M., Grossman, S. R., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.27367 · Cited by 27 · see citing works

Targeting mTOR Signaling in Type 2 Diabetes Mellitus and Diabetes Complications

Yang, L., Zhang, Z., Wang, D., Jiang, Y., & Liu, Y. (2022) · Current Drug Targets · doi:10.2174/1389450123666220111115528 · Cited by 27 · see citing works

Amino Acid–Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet

Kimball, S., Ravi, S., Gordon, B. S., Dennis, M. D., & Jefferson, L. (2015) · Journal of NutriLife · doi:10.3945/jn.115.215491 · Cited by 29 · see citing works

The potential of sestrins as therapeutic targets for diabetes

Dong, X. C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1044976 · Cited by 26 · see citing works

The mTOR pathway in Gliomas: From molecular insights to targeted therapies

Pournajaf, S., & Pourgholami, M. H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118237 · Cited by 24 · see citing works

Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases

Fang, Z., Kim, H.-G., Huang, M., Chowdhury, K., Li, M. O., Liangpunsakul, S., & Dong, X. C. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.04.015 · Cited by 23 · see citing works

Sestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose Tissue

Ro, S., Semple, I. A., Ho, A., Park, H., & Lee, J. H. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00114 · Cited by 23 · see citing works

Sestrins: Darkhorse in the regulation of mitochondrial health and metabolism

Kumar, A. A., Dhiman, D., & Shaha, C. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05769-w · Cited by 23 · see citing works

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling

Wang, X., Liu, W., Zhuang, D., Hong, S., & Chen, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21487 · Cited by 22 · see citing works

The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) study

de Boer, S. P. M., Baran, Y., García‐García, H. M., Eskin, I., Lenzen, M. J., Kleber, M. E., Regar, E. S., de Jaegere, P. P. T., Ligthart, J. M. R., van Geuns, R., et al. (2018) · EuroIntervention · doi:10.4244/eij-d-17-00180 · Cited by 20 · see citing works

Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3

Han, X., Yang, Y., Liu, S., Niu, Y., Shao, H., & Fu, L. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166568 · Cited by 19 · see citing works

Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle

Navas‐Enamorado, I., Bernier, M., Brea‐Calvo, G., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.005 · Cited by 19 · see citing works

Sestrins are Gatekeepers in the Way from Stress to Aging and Disease

Dalina, A. A., Kovaleva, I. E., & Budanov, A. V. (2018) · Molecular Biology · doi:10.1134/s0026893318060043 · Cited by 20 · see citing works

Signal Transduction and Molecular Regulation in Fatty Liver Disease

Dong, X. C., Chowdhury, K., Huang, M., & Kim, H.-G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0076 · Cited by 18 · see citing works

Effect of Lactobacillus delbrueckii Subsp. lactis PTCC1057 on Serum Glucose, Fetuin-A ,and Sestrin 3 Levels in Streptozotocin-Induced Diabetic Mice

Hallajzadeh, J., Eslami, R. D., & Tanomand, A. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09693-0 · Cited by 17 · see citing works

Insulin-induced mTOR signaling and gluconeogenesis in renal proximal tubules: A mini-review of current evidence and therapeutic potential

Nakamura, M., Satoh, N., Horita, S., & Nangaku, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1015204 · Cited by 17 · see citing works

Role of natural mTOR inhibitors in treatment of diabetes mellitus

Noori, T., Sureda, A., & Shirooie, S. (2022) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12851 · Cited by 15 · see citing works

GLP-1 receptor agonists modulate blood glucose levels in T2DM by affecting Faecalibacterium prausnitzii abundance in the intestine

Liang, L., Rao, E., Zhang, X., Wu, B., Su, X., Chen, L., Nie, R., & Nian, X. (2023) · Medicine · doi:10.1097/md.0000000000034978 · Cited by 15 · see citing works

Bta-miR-330 promotes bovine intramuscular pre-adipocytes adipogenesis via targeting SESN3 to activate the Akt-mTOR signaling pathway

Yang, Z., Ma, X., Zhang, D., Li, B., Gao, N., Li, X., Mei, C., & Zan, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133650 · Cited by 15 · see citing works

Cестрины – шлагбаумы на путях от стресса к старению и болезням

Dalina, A. A., Kovaleva, I. E., & Budanov, A. V. (2018) · Molecular Biology · doi:10.1134/s0026898418060046 · Cited by 15 · see citing works

Pathological Consequences of Hepatic mTORC1 Dysregulation

Cho, C., Kowalsky, A. H., & Lee, J.-H. (2020) · Genes · doi:10.3390/genes11080896 · Cited by 15 · see citing works

Metabolic Adaptations to Exercise Training

Liu, S., Niu, Y., & Fu, L. (2019) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-019-0018-3 · Cited by 14 · see citing works

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B. A., Mukaida, S., Bengtsson, T., Hutchinson, D. S., & Sato, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14616 · Cited by 14 · see citing works

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle

Zeng, N., D'Souza, R., Sorrenson, B., Merry, T., Barnett, M., Mitchell, C., & Cameron-Smith, D. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3853-8 · Cited by 12 · see citing works

Sestrin3 enhances macrophage-mediated generation of T helper 1 and T helper 17 cells in a mouse colitis model

Ge, L., Xu, M. J., Brant, S. R., Liu, S., Zhu, C., Shang, J., Zhao, Q., & Zhou, F. (2020) · International Immunology · doi:10.1093/intimm/dxaa016 · Cited by 12 · see citing works

The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth

Soliman, G. A., Shukla, S. K., Etekpo, A., Gunda, V., Steenson, S., Gautam, N., Alnouti, Y., & Singh, P. K. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa131 · Cited by 8 · see citing works

Increased Sestrin3 Contributes to Post-ischemic Seizures in the Diabetic Condition

Shi, Z., Lei, Z., Wu, F., Xia, L., Ruan, Y., & Xu, Z. C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.591207 · Cited by 8 · see citing works

Glucose-Induced Activation of mTORC1 is Associated with Hexokinase2 Binding to Sestrins in HEK293T Cells

Roberson, P. A., Kincheloe, G. N., Welles, J. E., Xu, D., Sam-Clarke, M., MacLean, P. S., Lang, C. H., Jefferson, L. S., & Kimball, S. R. (2022) · Journal of Nutrition · doi:10.1016/j.tjnut.2022.11.021 · Cited by 7 · see citing works

Specificity and sensitivity of the SeLECT score in predicting late seizures in patients undergoing intravenous thrombolytic treatment and the effect of diabetes mellitus and leukoaraiosis

Dinç, Y., Demir, A. B., Özkaya, G., & Bakar, M. (2023) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0043-1767764 · Cited by 7 · see citing works

Role of sestrins in metabolic and aging-related diseases

Fang, H., Shi, X., Wan, J., & Zhong, X. (2023) · Biogerontology · doi:10.1007/s10522-023-10053-y · Cited by 7 · see citing works

Immunoregulation: the interplay between metabolism and redox homeostasis

Perpiñán, E., Fueyo, A. S., & Safinia, N. (2023) · Frontiers in Transplantation · doi:10.3389/frtra.2023.1283275 · Cited by 6 · see citing works

The multifaceted role of Sestrin 3 (SESN3) in oxidative stress, inflammation and tumorigenesis

Chen, Q., Zhong, G., Fang, X., Lin, C., Wang, S., & Li, M. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2025.119938 · Cited by 6 · see citing works

mTORC2: A neglected player in aging regulation

Xu, W., Chen, H., & Xiao, H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31363 · Cited by 6 · see citing works

Tanycytes from a bird’s eye view: gene expression profiling of the tanycytic region under different seasonal states in the Svalbard ptarmigan

Appenroth, D., West, A. C., Wood, S. H., & Hazlerigg, D. G. (2024) · Journal of Comparative Physiology A · doi:10.1007/s00359-024-01716-3 · Cited by 6 · see citing works

Sestrin2 and Sestrin3 protect spermatogenesis against heat-induced meiotic defects

Chen, W., Wang, M., Wang, H., Jiang, Y., Zhu, J., Zeng, X., Xie, H., Yang, Q., & Sun, Y. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae042 · Cited by 6 · see citing works

Prediction and Validation of Transcription Factors Modulating the Expression of Sestrin3 Gene Using an Integrated Computational and Experimental Approach

Srivastava, R., Zhang, Y., Xiong, X., Zhang, X., Pan, X., Dong, X. C., Liangpunsakul, S., & Janga, S. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160228 · Cited by 6 · see citing works

Unlocking the benefits of aerobic exercise for MAFLD: a comprehensive mechanistic analysis

Zhang, B., Hu, Y., Zou, F., Ding, L., & Jiang, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07535-7 · Cited by 6 · see citing works

Sestrins’ Expression in the Liver Is Not Altered by Short-Term Calorie Restriction in Young and Old Rats

Wrońska, A., Zubrzycki, A., & Kmieć, Z. (2022) · Gerontology · doi:10.1159/000521639 · Cited by 5 · see citing works

Modeling microRNA ‐driven post‐transcriptional regulation using exon–intron split analysis in pigs

Mármol‐Sánchez, E., Cirera, S., Zingaretti, L. M., Jacobsen, M. J., Ramayo‐Caldas, Y., Jørgensen, C. B., Fredholm, M., Cardoso, T. F., Quintanilla, R., & Amills, M. (2022) · Animal Genetics · doi:10.1111/age.13238 · Cited by 5 · see citing works

Potential Role of SESN3 in Linking Heart Failure with Preserved Ejection Fraction and Chronic Obstructive Pulmonary Disease via Autophagy Dysregulation

Zhu, R., Yuan, B., Li, Y., Liu, X., Huang, M., Jiao, B., Sun, Y. H., Gao, S., Sun, X., Liu, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115174 · Cited by 4 · see citing works

Sestrin1, 2, and 3 are dispensable for female fertility in mice

Wang, M., Chen, W., Zeng, X., Wang, T., Sun, Y., & Yang, Q. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01345-z · Cited by 4 · see citing works

Integration of genomic and transcriptomic data of inbred mouse models for polygenic obesity and leanness revealed “obese” and “lean” candidate alleles in polyadenylation signals

Šimon, M., Mikec, Š., Morton, N. M., Atanur, S. S., Horvat, S., & Kunej, T. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.101903 · Cited by 4 · see citing works

Beckwith-Wiedemann syndrome and large offspring syndrome involve alterations in methylome, transcriptome, and chromatin configurationPreprint

Li, Y., Xiao, P., Boadu, F., Goldkamp, A. K., Nirgude, S., Cheng, J. J., Hagen, D. E., Kalish, J. M., & Rivera, R. M. (2023) · medRxiv · doi:10.1101/2023.12.14.23299981 · Cited by 4 · see citing works

What’s Diet Got to Do With It? Basic and Clinical Science Behind Diet and Acne

Dodds, M. (2022) · Cutis · doi:10.12788/cutis.0565 · Cited by 3 · see citing works

Sestrins: a new therapeutic target for endothelial dysfunction and cardiovascular disease prevention

Li, C., & Zhang, X. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2578729 · Cited by 2 · see citing works

Mechanisms of Protection Against Oxidative Stress During Hibernation

Shemarova, & Nikitina, E. R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031319 · Cited by 2 · see citing works

Restoration of Sestrin 3 Expression Mitigates Cardiac Oxidative Damage in Ischemia–Reperfusion Injury Model

Park, M., Cho, S., & Jeong, D. (2025) · Antioxidants · doi:10.3390/antiox14010061 · Cited by 2 · see citing works

The Expanding Role of the mammalian Target of RapamycinComplex 2 (mTORC2) in Cellular Metabolism

Soliman, G. A. (2015) · Archives of Medicine · Cited by 2 · see citing works

Sestrin2 at the crossroads of cardiovascular disease and diabetes: A comprehensive review

Sivakumar, R., Senghor, K. A. A., Vinodhini, V. M., & Kumar, J. S. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100558 · Cited by 1 · see citing works

Sestryny jako modulatory procesów starzenia i chorób związanych z wiekiem*

Gabryel, B., & Duszkiewicz, R. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.9471 · Cited by 1 · see citing works

The Role of Sestrins in the Regulation of the Cellular Response to Stress

Budanov, A. V. (2022) · Biology Bulletin Reviews · doi:10.1134/s2079086422040028 · Cited by 1 · see citing works

Modeling microRNA-driven post-transcriptional regulation by using exon-intron split analysis (EISA) in pigsPreprint

Mármol‐Sánchez, E., Cirera, S., Zingaretti, L. M., Jacobsen, M. J., Ramayo‐Caldas, Y., Jørgensen, C. B., Fredholm, M., Cardoso, T. F., Quintanilla, R., & Amills, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.14.452370

Beckwith–Wiedemann syndrome and large offspring syndrome involve alterations in methylome, transcriptome, and chromatin configuration

Li, Y., Xiao, P., Boadu, F., Goldkamp, A. K., Nirgude, S., Cheng, J. J., Hagen, D. E., Kalish, J. M., & Rivera, R. M. (2025) · NAR Molecular Medicine · doi:10.1093/narmme/ugaf036 · Cited by 4 · see citing works

Leucine Enhances Stress Resistance in Honeybees (Apis mellifera L.) by Modulating Sestrin-Dependent Antioxidant Responses

Wang, Z., Liu, Z. L., Zhang, G., Wang, H. Y., Chi, X., Wang, Y., & Xu, B. (2026) · Biology · doi:10.3390/biology15141124

Persistent Body Mass Index Profiles During Adolescence: Associations With Brain Maturation and DNA Methylation

Yu, X., Xiang, S., Jia, T., Zhang, Z., Sun, Y., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Brühl, R., Garavan, H., et al. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100820

Sestrin1 Alleviates Metabolic Dysfunction-Associated Steatohepatitis by Inhibiting the mTORC1 Signaling Pathway

Hu, G. H., Chen, Y. F., Bai, W. Y., Huang, H., Zhang, J., Zhang, L. R., Zhang, S. M., Chen, J. X., Zhou, J. J., & Zhang, Z. ‐. (2026) · Molecular Biology · doi:10.1134/s0026893325605312

Sestrins as Multifunctional Regulators of Cell Viability on the Pathways from Stress to Aging

Haidurov, A., & Budanov, A. V. (2026) · Biochemistry (Moscow) · doi:10.1134/s0006297926601991

Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

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Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.004 · Cited by 295 · see citing works

Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3

Han, X., Yang, Y., Liu, S., Niu, Y., Shao, H., & Fu, L. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166568 · Cited by 19 · see citing works

Glucose Availability Regulates Sestrin3 Binding to Hexokinase2 to Affect Glucose‐induced mTORC1 Activation

Roberson, P. A., Welles, J. E., Xu, D., Kincheloe, G. N., Jefferson, L. S., & Kimball, S. R. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r5903

The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Kowalsky, A. H., Namkoong, S., Mettetal, E., Park, H.-W., Kazyken, D., Fingar, D., & Lee, J.-H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010857 · Cited by 52 · see citing works