Recent insights into the biological functions of sestrins in health and disease

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science · doi:10.1126/science.1095569 · Cited by 731 · see citing works

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works

Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage

Bae, S. H., Sung, S. H., Oh, S. Y., Lim, J. M., Lee, S. K., Park, Y. N., Lee, H. E., Kang, D., & Rhee, S. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.002 · Cited by 492 · see citing works

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.014 · Cited by 466 · see citing works

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Saxton, R. A., Knockenhauer, K. E., Wolfson, R. L., Chantranupong, L., Pacold, M. E., Wang, T., Schwartz, T. U., & Sabatini, D. M. (2016) · Science · doi:10.1126/science.aad2087 · Cited by 457 · see citing works

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Budanov, A. V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205877 · Cited by 363 · see citing works

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

Lee, J. H., Budanov, A. V., & Karin, M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.018 · Cited by 339 · see citing works

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.004 · Cited by 295 · see citing works

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

Kim, M., Bae, S. H., Ryu, J., Kwon, Y., Oh, J.-H., Kwon, J., Moon, J., Kim, K., Miyawaki, A., Lee, M. G., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1183081 · Cited by 286 · see citing works

A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging

Lanna, A., Gomes, D. C. O., Muller-Durovic, B., McDonnell, T., Escors, D., Gilroy, D. W., Lee, J. H., Karin, M., & Akbar, A. N. (2017) · Nature Immunology · doi:10.1038/ni.3665 · Cited by 284 · see citing works

Impaired Distal Airway Development in Mice Lacking Elastin

Wendel, D. P., Taylor, D. G., Albertine, K. H., et al. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.3.3906 · Cited by 280 · see citing works

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 249 · see citing works

Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury

Ishihara, M., Urushido, M., Hamada, K., Matsumoto, T., Shimamura, Y., Ogata, K., Inoue, K., Taniguchi, Y., Horino, T., Fujieda, M., et al. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00642.2012 · Cited by 195 · see citing works

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Kim, J. S., Ro, S.-H., Kim, M., Park, H.-W., Semple, I. A., Park, H., Cho, U., Wang, W., Guan, K., Karin, M., et al. (2015) · Scientific Reports · doi:10.1038/srep09502 · Cited by 177 · see citing works

Hepatoprotective role of Sestrin2 against chronic ER stress

Park, H., Park, H., Ro, S., Jang, I., Semple, I. A., Kim, D. N., Kim, M., Nam, M., Zhang, D., Yin, L., et al. (2014) · Nature Communications · doi:10.1038/ncomms5233 · Cited by 176 · see citing works

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

Johnson, M. R., Behmoaras, J. V., Bottolo, L., Krishnan, M. L., Pernhorst, K., Santoscoy, P. L. M., Rossetti, T., Speed, D., Srivastava, P. K., Chadeau‐Hyam, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7031 · Cited by 174 · see citing works

Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart

Morrison, A., Chen, L., Wang, J., Zhang, M., Yang, H. M., Ma, Y., Budanov, A. V., Lee, J. H., Karin, M., & Li, J. (2014) · The FASEB Journal · doi:10.1096/fj.14-258814 · Cited by 167 · see citing works

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Kim, H., An, S., Ro, S.-H., Teixeira, F., Park, G. J., Kim, C., Cho, C., Kim, J.-S., Jakob, U., Lee, J.-H., et al. (2015) · Nature Communications · doi:10.1038/ncomms10025 · Cited by 152 · see citing works

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner

Kim, G. T., Lee, S. H., Kim, J., & Kim, Y. M. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1658 · Cited by 146 · see citing works

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

Eid, A. A., Lee, D.-Y., Roman, L. J., Khazim, K., & Gorin, Y. C. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00217-13 · Cited by 135 · see citing works

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J. P., Gewillig, M. H. M. L., Nakamura, Y., Niikawa, N., et al. (2003) · Human Genetics · doi:10.1007/s00439-003-0917-5 · Cited by 117 · see citing works

Role of sestrin2 in the regulation of proinflammatory signaling in macrophages

Yang, J. H., Kim, K. M., Kim, M. G., Seo, K. H., Han, J. Y., Ka, S., Park, B., Shin, S. M., Ku, S., Cho, I. J., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.002 · Cited by 108 · see citing works

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling

Tao, R., Xiong, X., Liangpunsakul, S., & Dong, X. C. (2015) · Diabetes · doi:10.2337/db14-0539 · Cited by 96 · see citing works

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

Ro, S., Xue, X., Ramakrishnan, S. K., Cho, C., Namkoong, S., Jang, I., Semple, I. A., Ho, A., Park, H., Shah, Y. M., et al. (2016) · eLife · doi:10.7554/elife.12204 · Cited by 96 · see citing works

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

Kim, H. J., Joe, Y., Kim, S., Park, S., Park, J., Chen, Y., Kim, J., Ryu, J., Cho, G. J., Surh, Y., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.026 · Cited by 96 · see citing works

Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells

Kim, G. T., Lee, S. H., & Kim, Y. M. (2013) · Journal of Cancer Prevention · doi:10.15430/jcp.2013.18.3.264 · Cited by 92 · see citing works

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats

Li, L., Xiao, L., Hou, Y., He, Q., Zhu, J., Li, Y., Wu, J., Zhao, J., Yu, S., & Zhao, Y. (2016) · Scientific Reports · doi:10.1038/srep30272 · Cited by 92 · see citing works

Role of sestrin2 in peroxide signaling in macrophages

Essler, S., Dehne, N., & Brüne, B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.017 · Cited by 90 · see citing works

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

Ro, S., Nam, M., Jang, I., Park, H., Park, H., Semple, I. A., Kim, M., Kim, J. S., Park, H., Einat, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401787111 · Cited by 89 · see citing works

Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-Dependent autophagy activation

Hou, Y.-S., Guan, J.-J., Xu, H.-D., Wu, F., Sheng, R., & Qin, Z.-H. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00285-15 · Cited by 87 · see citing works

Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes

Li, H., Liu, S., Yuan, H., Niu, Y., & Fu, L. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.023 · Cited by 77 · see citing works

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture

Chen, Y., Chen, S., Wu, C., Huang, S.-S., & Yang, D. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.009 · Cited by 73 · see citing works

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

Yang, Y.-L., Loh, K.-S., Liou, B.-Y., Chu, I., Kuo, C., Chen, H., & Chen, C. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2012.12.011 · Cited by 72 · see citing works

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

Shi, X.-D., Xu, L., Doycheva, D., Tang, J.-P., Yan, M., & Zhang, J. H. (2017) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x16656201 · Cited by 72 · see citing works

Regulation of Toll-like Receptor-Mediated Sestrin2 Induction by AP-1, Nrf2, and the Ubiquitin-Proteasome System in Macrophages

Kim, M. G., Yang, J. H., Kim, K. M., Jang, C. H., Jung, J. Y., Cho, I. J., Shin, S. M., & Ki, S. H. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv012 · Cited by 70 · see citing works

Sestrin2 Decreases Renal Oxidative Stress, Lowers Blood Pressure, and Mediates Dopamine D 2 Receptor–Induced Inhibition of Reactive Oxygen Species Production

Yang, Y., Cuevas, S., Yang, S., Villar, V. A. M., Escano, C. S., Asico, L. D., Yu, P., Jiang, X., Weinman, E. J., Armando, I., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03840 · Cited by 67 · see citing works

Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury

Kallenborn-Gerhardt, W., Lu, R., Syhr, K. M. J., Heidler, J., von Melchner, H., Geißlinger, G., Bangsow, T., & Schmidtko, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4958 · Cited by 66 · see citing works

Upregulation of sestrin-2 expression protects against endothelial toxicity of angiotensin II

Lao, Y., Li, F., Yong, Y., Dong, J., Zhang, L., Huang, X., Li, F., & Jiewen, L. (2014) · Cell Biology and Toxicology · doi:10.1007/s10565-014-9276-3 · Cited by 52 · see citing works

Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer

Wei, J., Fu, Z., FANG, M., Guo, J., Zhao, Q., Lu, W., & Zhou, Q. (2014) · Oncology Reports · doi:10.3892/or.2014.3701 · Cited by 52 · see citing works

Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation

Seo, K., Seo, S., Ki, S. H., & Shin, S. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.014 · Cited by 52 · see citing works

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation

Xue, R., Zeng, J., Chen, Y., Chen, C., Tan, W., Zhao, J., Dong, B., Sun, Y., Dong, Y., & Liu, C. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13052 · Cited by 51 · see citing works

Inactivation of sestrin 2 induces TGF-β signaling and partially rescues pulmonary emphysema in a mouse model of COPD

Wempe, F., De-Zolt, S., Koli, K. M., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner‐Kock, A., Weißmann, N., Keski‐Oja, J., & von Melchner, H. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004234 · Cited by 50 · see citing works

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle

Nascimento, E. B. M., Osler, M. E., & Zierath, J. R. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00212.2013 · Cited by 49 · see citing works

Sestrin2 protects against acetaminophen-induced liver injury

Kim, S. J., Kim, K. M., Yang, J. H., Cho, S. S., Kim, J. Y., Park, S. J., Lee, S., Ku, S., Cho, I. J., & Ki, S. H. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.02.002 · Cited by 47 · see citing works

Upregulation of Sestrin-2 Expression via P53 Protects Against 1-Methyl-4-Phenylpyridinium (MPP+) Neurotoxicity

Daixing, Z., Chengye, Z., Zhong, Q., & Li, S. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0081-x · Cited by 45 · see citing works

Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation

Ding, B., Parmigiani, A., Chen, Y., & Budanov, A. V. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1084447 · Cited by 45 · see citing works

Upregulation of Sestrin2 Expression Protects Against Macrophage Apoptosis Induced by Oxidized Low-Density Lipoprotein

Hu, H., Shi, Z., Lin, X., Chen, S., Wang, Q.-Y., & Tang, S. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2627 · Cited by 41 · see citing works

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

Parmigiani, A., & Budanov, A. V. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.003 · Cited by 38 · see citing works

Relative Alterations in Blood-Based Levels of Sestrin in Alzheimer’s Disease and Mild Cognitive Impairment Patients

Rai, N., Kumar, R. K., Desai, G. R., Gunasekaran, V., Shekhar, S., Chatterjee, P., Tripathi, M., Upadhyay, A. D., Dwivedi, S. N., Dey, A. B., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160479 · Cited by 34 · see citing works

Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation

Dong, Z., Lin, C., Liu, Y., Jin, H., Wu, H., Li, Z., Sun, L., Zhang, L., Hu, X., Wei, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep46307 · Cited by 32 · see citing works

An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling

Xu, H., Sun, H., Zhang, H., Liu, J., Fan, F., Li, Y., Ning, X., Sun, Y., Dai, S., Liu, B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124033 · Cited by 30 · see citing works

Amino Acid–Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet

Kimball, S., Ravi, S., Gordon, B. S., Dennis, M. D., & Jefferson, L. (2015) · Journal of NutriLife · doi:10.3945/jn.115.215491 · Cited by 29 · see citing works

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells

Khan, N., Jajeh, F., Khan, M. I., Mukhtar, E., Shabana, S. M., & Mukhtar, H. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw124 · Cited by 29 · see citing works

Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD

Heidler, J., Fysikopoulos, A., Wempe, F., Seimetz, M., Bangsow, T., Tomasovic, A., Veit, F., Scheibe, S., Pichl, A., Weisel, F. C., et al. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.013482 · Cited by 28 · see citing works

The critical role of Sestrin 1 in regulating the proliferation of cardiac fibroblasts

Sun, G., Xue, R., Yao, F., Liu, D., Huang, H., Chen, C., Li, Y., Zeng, J., Zhang, G., Dong, Y., et al. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.11.011 · Cited by 27 · see citing works

Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells

Hamatani, H., Hiromura, K., Sakairi, T., Takahashi, S., Watanabe, M., Maeshima, A., Ohse, T., Pippin, J. W., Shankland, S. J., & Nojima, Y. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00625.2013 · Cited by 26 · see citing works

The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury

Kang, X., Petyaykina, K., Tao, R., Xiong, X., Dong, X. C., & Liangpunsakul, S. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00373.2013 · Cited by 26 · see citing works

The potential of sestrins as therapeutic targets for diabetes

Dong, X. C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1044976 · Cited by 26 · see citing works

Sestrin2: A Promising Therapeutic Target for Liver Diseases

Kim, K. M., Yang, J. H., Shin, S. M., Cho, I. J., & Ki, S. H. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00228 · Cited by 25 · see citing works

Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway

Chai, D.-D., Wang, G., Zhou, Z., Yang, H., & Yu, Z. (2015) · International Journal of Endocrinology · doi:10.1155/2015/505849 · Cited by 25 · see citing works

Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespan

Chen, J., Tarry‐Adkins, J. L., Matharu, K., Yeo, G. S. H., & Ozanne, S. E. (2010) · Clinical Science · doi:10.1042/cs20100230 · Cited by 25 · see citing works

Sestrin2 protects the myocardium against radiation-induced damage

Zeng, Y.-C., Chi, F., Xing, R., Zeng, J., Gao, S., Chen, J., Wang, H.-M., Duan, Q.-Y., Sun, Y.-N., Niu, N., et al. (2016) · Radiation and Environmental Biophysics · doi:10.1007/s00411-016-0643-8 · Cited by 23 · see citing works

Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells

Tsilioni, I., Filippidis, A., Kerenidi, T., Budanov, A. V., Zarogiannis, S. G., & Gourgoulianis, K. I. (2016) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2016.02.002 · Cited by 21 · see citing works

Sestrin family may play important roles in the regulation of cardiac pathophysiology

Liao, H.-H., Ruan, J., Liu, H.-J., Liu, Y., Feng, H., & Tang, Q. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.08.164 · Cited by 16 · see citing works

Role of sestrin2 in H 2 O 2 -induced PC12 apoptosis

Liu, A., Yu, Q., Xiao, S., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.043 · Cited by 7 · see citing works

Sestrin 2: a regulator of the glomerular parietal epithelial cell phenotype

Smeets, B., & Huber, T. B. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00435.2014 · Cited by 5 · see citing works

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works

Discovery of NV-5138, the first selective Brain mTORC1 activator

Sengupta, S., Giaime, E., Narayan, S., Hahm, S., Howell, J., O’Neill, D., Vlasuk, G. P., & Saiah, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-40693-5 · Cited by 72 · see citing works

Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway

Han, X., Ding, C., Zhang, G., Pan, R., Liu, Y., Huang, N., Hou, N., Han, F., Xu, W., & Sun, X. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.03.032 · Cited by 63 · see citing works

Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

Mohankumar, K., Lee, J., Wu, C. S., Sun, Y., & Safe, S. (2018) · Endocrinology · doi:10.1210/en.2017-03049 · Cited by 24 · see citing works

Autophagy in cancer biology and therapy

Noor, N., Gammoh, Simon, 。., et al. (2014) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Is Selective Autophagy Distinct from Starvation-Induced Autophagy?

Guillebaud, G., & Germain, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00005-3

Death and survival of neuronal and astrocytic cells in ischemic brain injury： a role of autophagy

Min, Xü, Huiling, et al. (2011) · 中国药理学报：英文版 · Cited by 1 · see citing works

There is more to autophagy than induction

Klionsky, D. J., & Nemchenko, A. (2011) · Autophagy · doi:10.4161/auto.7.8.16609 · Cited by 4 · see citing works

Roles of autophagy in lymphocytes： reflections and directions

Ian, I., McLeod, You-wen, et al. (2010) · 中国免疫学杂志：英文版 · Cited by 1 · see citing works