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Cited by 106Pancreatic function and diabetesMicroRNA in disease regulationDiabetes and associated disorders

β-Cell MicroRNAs: Small but Powerful

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Filios, Stephen R., Shalev, Anath·2015·Diabetes
DOI 10.2337/db15-0831PMC PMC4613982
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Abstract

Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of genes and pathways potentially affected is huge. Not surprisingly, many miRs have also been implicated in diabetes, and more recently, some have been discovered to play important roles in the pancreatic islet, including β-cell function, proliferation, and survival. The goal of this Perspective is to offer an overview of this rapidly evolving field and the miRs involved, reveal novel networks of β-cell miR signaling, and provide an outlook of the opportunities and challenges ahead.

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  • The increase in miR-29 in β-cells exposed to elevated glucose mediates the reduction of glucose-stimulated insulin secretion caused by long-term hypoglycemia via reduced expression of syntaxin-1.

    “MiR-29 is increased in β-cells exposed to elevated glucose and it was proposed that this mediates the reduction of glucose-stimulated insulin secretion caused by long-term hypoglycemia via reduced expression of syntaxin-1 (186, 218).”

    From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [186]

    In “Insulin Secretion: Preventing Excess” (page not provided), the review says miR-29 increases in response to glucose and that the associated decrease in syntaxin-1 negatively affects glucose-stimulated insulin secretion. It does not attribute that reduction to long-term hypoglycemia; that condition is unsupported. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

  • MiR-29 is increased in β-cells exposed to elevated glucose.

    “MiR-29 is increased in β-cells exposed to elevated glucose and it was proposed that this mediates the reduction of glucose-stimulated insulin secretion caused by long-term hypoglycemia via reduced expression of syntaxin-1 (186, 218).”

    From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [186]

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Authors
Filios, S. R., & Shalev, A.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Shalev, Anath
ORCID
Shalev, Anath
Venue
Diabetes
Publisher
American Diabetes Association
Published
2015-10-14
Volume
64
Issue
11
Pages
3631-3644
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/db15-0831
PMC
PMC4613982
OpenAlex
W2097687832
Cited by
106
References
7
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 11 · 2021: 15 · 2020: 13 · 2019: 16 · 2018: 11 · 2017: 15 · 2016: 12
FWCI
2.43
Type
journal article
Language
en
Open access
Licence
www.diabetesjournals.org/site/license (vor, 200 d)
Locations
  • Diabetes (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (R01DK078752)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
microRNA, pancreatic beta cells, beta-cell function, beta-cell proliferation, beta-cell survival, pancreatic islets, non-coding RNA
MeSH terms
Cell Differentiation, Cell Survival, Diabetes Mellitus, Humans, Signal Transduction, MicroRNAs, Cell Proliferation, Insulin-Secreting Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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