Perirenal Fat Thickness Is Significantly Associated With the Risk for Development of Chronic Kidney Disease in Patients With Diabetes
Open accessAbstract
Perirenal fat is adjacent to kidneys and active in metabolism and adipokine secretion. We aimed to investigate whether perirenal fat is an independent predictor for chronic kidney disease (CKD) and compared it with total, subcutaneous, or visceral fat in patients with diabetes. Perirenal fat thickness (PRFT) was measured by computed tomography, and total body fat (TBF), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) were assessed by DEXA. In cross-sectional analysis, patients with higher PRFT had a lower estimated glomerular filtration rate (eGFR). Multiple linear regression analysis showed a negative correlation between PRFT and eGFR after confounders adjustment. No association between eGFR and TBF, SAT, or VAT was observed. Longitudinally, 190 patients with type 2 diabetes mellitus (T2DM) without CKD at baseline were followed for 2 years. A total of 29 participants developed CKD. After VAT-based multivariate adjustment, each SD (per-SD) increment in baseline PRFT was associated with a higher incidence of CKD (hazard ratio 1.67, 95% CI 1.04–2.68), while TBF, SAT, and VAT were not. Furthermore, PRFT predicted CKD, with a C-statistic (95% CI) of 0.668 (0.562, 0.774), which was higher than that of TPF [0.535 (0.433, 0.637)], SAT [0.526 (0.434, 0.618)], and VAT [0.602 (0.506, 0.698)]. In conclusion, with perirenal fat there was a higher predictive value for CKD than with total, subcutaneous, or visceral fat in T2DM.
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Increased perirenal fat and hilar fat have been linked to CKD.
“Specifically, increased perirenal fat (46) and hilar fat (47) have been linked to CKD.”
From GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity (2025) · cites this paper as [46]
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- Authors
- Chen, X., Mao, Y., Hu, J., Han, S., Gong, L., Luo, T., Yang, S., Qing, H., Wang, Y., Du, Z., Mei, M., Zheng, L., Lv, X., Tang, Y., Zhao, Q., Zhou, Y., He, J. C., Li, Q., & Wang, Z.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- University of California, Berkeley (US)
- Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Department of Medicine/Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY
- Corresponding author
- Li, Qifu
- Wang, Zhihong
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2021-06-22
- Volume
- 70
- Issue
- 10
- Pages
- 2322-2332
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W3174570524
- Cited by
- 92
- References
- 47
- Citations by year
- 2026: 15 · 2025: 30 · 2024: 19 · 2023: 17 · 2022: 10 · 2021: 1
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81970720, [2015], 81770851, 81800731, 2017YFC0909600, 81800757, 81700754, 81870567)
- Chongqing Medical University
- China International Medical Foundation (Z-2017-26-1902)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- perirenal fat thickness, chronic kidney disease, type 2 diabetes, visceral adipose tissue, subcutaneous adipose tissue, total body fat, estimated glomerular filtration rate, CKD prediction, adipose tissue
- MeSH terms
- Aged, China, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Humans, Kidney, Male, Middle Aged, Organ Size, Risk Factors, Tomography, X-Ray Computed, Intra-Abdominal Fat, Adiposity, Renal Insufficiency, Chronic
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