A1C underestimates glycemia in HIV infection

Kim, Peter S.; Woods, Christian; Georgoff, Patrick; Crum, Dana; Rosenberg, Alice; Smith, Margo; Hadigan, Colleen

doi:10.2337/dc09-0177

Cited by 145HIV-related health complications and treatmentsDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

A1C underestimates glycemia in HIV infection

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Kim, Peter S., Woods, Christian, Georgoff, Patrick, Crum, Dana, Rosenberg, Alice, Smith, Margo, Hadigan, Colleen·2009·Diabetes Care

DOI 10.2337/dc09-0177PMC PMC2732167

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Abstract

OBJECTIVE: The objective of this study was to determine the relationship between A1C and glycemia in HIV infection. RESEARCH DESIGN AND METHODS: We completed a prospective cross-sectional study of 100 HIV-infected adults with type 2 diabetes (77%) or fasting hyperglycemia (23%) with measured glucose, A1C, mean corpuscular volume (MCV), and fructosamine. A total of 200 HIV-uninfected type 2 diabetic subjects matched for key demographic characteristics served as control subjects. RESULTS: Relative to the control subjects, A1C underestimated glucose by 29 +/- 4 mg/dl in the HIV-infected subjects. Current nucleoside reverse transcriptase inhibitors (NRTIs), higher MCV and hemoglobin, and lower HIV RNA and haptoglobin were associated with greater A1C-glucose discordance. However, only MCV and current NTRI use, in particular abacavir, remained significant predictors in multivariate analyses. Fructosamine more closely reflected glycemia in the HIV-infected subjects. CONCLUSIONS: A1C underestimates glycemia in HIV-infected patients and is related to NRTI use. Use of abacavir and increased MCV were key correlates in multivariate analyses. Fructosamine may be more appropriate in this setting.

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A1C may not be a suitable diagnostic test in people with anemia, people treated with erythropoietin, or people undergoing hemodialysis or HIV treatment.
“A1C may not be a suitable diagnostic test in people with anemia, people treated with erythropoietin, or people undergoing hemodialysis or HIV treatment (19,20).”
From 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024 (2024) · cites this paper as [20]
The Conclusions report that A1C underestimates glycemia in HIV-infected patients and that NRTI use is associated with the discrepancy, supporting caution during HIV treatment. The Research Design and Methods section says patients with anemia or renal disease were excluded; the paper does not establish the claim for anemia, erythropoietin treatment, or hemodialysis, nor does it directly evaluate A1C as a diagnostic test. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The A1C test may underestimate glycemia in people with HIV.
“The A1C test may underestimate glycemia in people with HIV; it is not recommended for diagnosis and may present challenges for monitoring (20).”
From 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024 (2024) · cites this paper as [20]
The Abstract’s Conclusions state that A1C underestimates glycemia in HIV-infected patients, and the Results report that it underestimated glucose relative to controls. The Conclusions also suggest fructosamine may be more appropriate, consistent with a monitoring concern. The cited paper does not state that A1C is not recommended for diagnosis, so that part of the citing sentence is unsupported. (LLM, conf=0.84)
Experimental — accuracy not yet measured
The A1C test may underestimate glycemia in people with HIV, so plasma glucose criteria are preferred to diagnose prediabetes and diabetes.
“As the A1C test may underestimate glycemia in people with HIV, plasma glucose criteria are preferred to diagnose prediabetes and diabetes (20).”
From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [20]
The Abstract Results and Conclusions report that A1C underestimated glycemia in the HIV-infected patients studied. The paper does not recommend plasma glucose criteria over A1C for diagnosing prediabetes or diabetes; its Conclusions instead suggest that fructosamine may be more appropriate for assessing glycemia in this setting. (LLM, conf=0.88)
Experimental — accuracy not yet measured
A1C may not be a suitable diagnostic test in people with anemia, people treated with erythropoietin, or people undergoing hemodialysis or HIV treatment.
“A1C may not be a suitable diagnostic test in people with anemia, people treated with erythropoietin, or people undergoing hemodialysis or HIV treatment (1,19,20).”
From 2. Diagnosis and classification of diabetes: standards of care in diabetes-2025 (2025) · cites this paper as [20]

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European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV*
Lundgren, J., Battegay, M., Behrens, G., De Wit, S., Guaraldi, G., Katlama, C., Martinez, E., Nair, D., Powderly, W., Reiss, P., et al. (2008) · HIV Medicine · doi:10.1111/j.1468-1293.2007.00534.x · Cited by 210 · see citing works
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Bosch, F. H., Werre, J. M., Roerdinkholder‐Stoelwinder, B., Huls, T., Willekens, F. L. A., & Halie, M. (1992) · Blood · doi:10.1182/blood.v79.1.254.bloodjournal791254 · Cited by 111 · see citing works
Association of erythrocyte indices with glycated haemoglobin in pre‐menopausal women
Koga, M., Morita, S., Saito, H., Mukai, M., & Kasayama, S. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02161.x · Cited by 77 · see citing works
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Diop, M.-E., Bastard, J., Meunier, N., Thévenet, S., Maachi, M., Capeau, J., Pialoux, G., & Vigouroux, C. (2006) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.22.1242 · Cited by 68 · see citing works
Multicenter Evaluation of Tosoh Glycohemoglobin Analyzer
Gibb, I., Parnham, A. J., Fonfrède, M., & Lecock, F. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.10.1833 · Cited by 53 · see citing works
Inaccurate Glycosylated Hemoglobin A1C Measurements in Human Immunodeficiency Virus—Positive Patients with Diabetes Mellitus
Polgreen, P. M., Putz, D., & Stapleton, J. T. (2003) · Clinical Infectious Diseases · doi:10.1086/376633 · Cited by 46 · see citing works
Causes of Macrocytosis in HIV-infected Patients not Treated with Zidovudine
é, D. G., Sudre, P., Anwar, D., ï, C. S., & Hirschel, B. J. (2000) · Journal of Infection · doi:10.1053/jinf.1999.0628 · Cited by 38 · see citing works
Mean cell volume (MCV) changes in HIV-positive patients taking nucleoside reverse transcriptase inhibitors (NRTIs): a surrogate marker for adherence
Steele, R. H., Keogh, G. L., Quin, J., Fernando, S. L., & Stojkova, V. (2002) · International Journal of STD & AIDS · doi:10.1258/095646202320753691 · Cited by 27 · see citing works
Evaluation of the analytic performances of the new HPLC system HLC-723 G7 for the measurement of hemoglobin A1C
Terreni, A., Paleari, R., Caldini, A. L., Ognibene, A., Mosca, A., & Messeri, G. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00116-4 · Cited by 15 · see citing works
Different DCCT-aligned HbA1c methods and the GMS contract
Twomey, P. J., & Pledger, D. R. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01655.x · Cited by 6 · see citing works
Level of serum fructosamine in Saudi diabetic patients
Ajabnoor, M. A., Zawawi, T. H., Marzouki, K. M. H., & Marzouki, Z. M. H. (1990) · Acta Diabetologica · doi:10.1007/bf02581282 · Cited by 4 · see citing works

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Thompson, M., Horberg, M. A., Agwu, A. L., Colasanti, J. A., Jain, M. K., Short, W. R., Singh, T., & Aberg, J. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1391 · Cited by 261 · see citing works
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Swanepoel, C. R., Atta, M. G., D’Agati, V. D., Estrella, M. M., Fogo, A. B., Naicker, S., Post, F. A., Wearne, N., Winkler, C. A., Cheung, M., et al. (2018) · Kidney International · doi:10.1016/j.kint.2017.11.007 · Cited by 243 · see citing works
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Medapalli, R. K., Parikh, C. R., Gordon, K. S., Brown, S. T., Butt, A. A., Gibert, C. L., Rimland, D., Rodriguez‐Barradas, M. C., Chang, C.-C. H., Justice, A. C., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825b70d9 · Cited by 98 · see citing works
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Tien, P. C., Schneider, M. F., Cox, C., Karim, R., Cohen, M. H., Sharma, A., Young, M., & Glesby, M. J. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31826bfc32 · Cited by 84 · see citing works
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Slama, L., Palella, F. J., Abraham, A. G., Li, X., Vigouroux, C., Pialoux, G., Kingsley, L., Lake, J. E., Brown, T. T., Margolick, J. B., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku295 · Cited by 71 · see citing works
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Qiu, H., Hou, N., Shi, J., Liu, Y., Kan, C., Han, F., & Sun, X. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i7.1057 · Cited by 63 · see citing works
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Blanco, F., Román, J. S., Vispo, E., López, M., Salto, A., Abad, V., & Soriano, V. (2010) · PubMed · Cited by 40 · see citing works
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Cardiac Disease Associated with Human Immunodeficiency Virus Infection
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Nguyen, K. A., Peer, N., de Villiers, A., Mukasa, B., Matsha, T. E., Mills, E. J., & Kengne, A. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211483 · Cited by 18 · see citing works
Prediabetes among HIV-infected individuals receiving antiretroviral therapy: prevalence, diagnostic tests, and associated factors
Phuphuakrat, A., Nimitphong, H., Reutrakul, S., & D, S. S. M. (2020) · AIDS Research and Therapy · doi:10.1186/s12981-020-00284-1 · Cited by 17 · see citing works
Prevalence of obesity and disturbances in glucose homeostasis in HIV‐infected subjects and general population – missed diagnoses of diabetes?
Hanttu, A. M., Kauppinen, K. J., Kivelä, P. S., Ollgren, J. P., Jousilahti, P., Liitsola, K., Koponen, P., & Sutinen, J. (2020) · HIV Medicine · doi:10.1111/hiv.13009 · Cited by 17 · see citing works
HbA1c in adults without known diabetes from southern Europe. Impact of the new diagnostic criteria in clinical practice
Bernal-López, M. R., Santamaria-Fernández, S., Lopez-Carmona, M. D., Tinahones, F. J., Mancera‐Romero, J., Peña-Jiménez, D., Jansen‐Chaparro, S., Baca-Osorio, A., Cuesta-Muñoz, A. L., Serrano‐Ríos, M., et al. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03317.x · Cited by 16 · see citing works
The effects of intermittent, CD4-guided antiretroviral therapy on body composition and metabolic parameters
Martínez, E., Visnegarwala, F., Grund, B., Thomas, A. J., Gibert, C. L., Shlay, J. C., Drummond, F., Pearce, D. D., Edwards, S., Reiss, P., et al. (2010) · AIDS · doi:10.1097/qad.0b013e3283333666 · Cited by 16 · see citing works
Assessment of glycaemic status in adult hospital patients for the detection of undiagnosed diabetes mellitus: A systematic review
Thornton‐Swan, T. D., Armitage, L. C., Curtis, A. M., & Farmer, A. A. (2021) · Diabetic Medicine · doi:10.1111/dme.14777 · Cited by 17 · see citing works
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Han, J., Gordon, K. S., Womack, J. A., Gibert, C. L., Leaf, D. A., Rimland, D., Rodriguez‐Barradas, M. C., & Bisson, G. P. (2016) · Diabetes Care · doi:10.2337/dc16-0718 · Cited by 15 · see citing works
Coronary artery disease in patients with human immunodeficiency virus infection
Mondal, P., Aljizeeri, A. H., Small, G. R., Malhotra, S., Harikrishnan, P., Affandi, J. S., Buechel, R. R., Dwivedi, G., Al-Mallah, M. H., & Jain, D. (2020) · Journal of Nuclear Cardiology · doi:10.1007/s12350-020-02280-4 · Cited by 15 · see citing works
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Njoroge, A., Augusto, O. J., Page, S. T., Kigondu, C., Oluka, M. N., Puttkammer, N. H., & Farquhar, C. (2021) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.292 · Cited by 14 · see citing works
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Zhao, Y. C., Wang, M., Meng, B., Gao, Y., Xue, Z., He, M., Jiang, Y., Dai, X., Yan, D., & Fang, X. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.677621 · Cited by 14 · see citing works
Commentary: Diagnostic Validity and Clinical Utility of HbA1c Tests for Type 2 Diabetes Mellitus
Owora, A. H. (2016) · Current Diabetes Reviews · doi:10.2174/1573399812666161129154559 · Cited by 14 · see citing works
Diabetes in a TB and HIV-endemic South African population: Analysis of a virtual cohort using routine health data
Tamuhla, T., Dave, J. A., Raubenheimer, P. J., & Tiffin, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251303 · Cited by 13 · see citing works
Non-Communicable Disease Preventive Screening by HIV Care Model
Rhodes, C. M., Chang, Y., Regan, S., & Triant, V. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169246 · Cited by 13 · see citing works
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Kim, S. Y., Friedmann, P., Seth, A., & Fleckman, A. M. (2014) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.4137/cmed.s19202 · Cited by 12 · see citing works
Validity of hemoglobin A1c for diagnosing diabetes among people with and without HIV in Uganda
Muchira, J. M., Stuart‐Shor, E., Manne‐Goehler, J., Lo, J., Tsai, A. C., Kakukire, B., Okello, S., & Siedner, M. J. (2019) · International Journal of STD & AIDS · doi:10.1177/0956462418823406 · Cited by 11 · see citing works
Diabetes, mortality and glucose monitoring rates in the TREAT Asia HIV Observational Database Low Intensity Transfer (TAHOD‐LITE) study
Bijker, R., Kumarasamy, N., Kiertiburanakul, S., Pujari, S. N., Sun, L. P., Ng, O. T., Lee, M., Choi, J. Y., Nguyen, K., Chan, Y. J., et al. (2019) · HIV Medicine · doi:10.1111/hiv.12779 · Cited by 11 · see citing works
The investigation of diabetes in people living with HIV: A systematic review
Daultrey, H. E., Yousseff, E., Wright, J. E., Davies, K. A., Chakera, A. J., & Levett, T. J. (2020) · Diabetic Medicine · doi:10.1111/dme.14454 · Cited by 11 · see citing works
An update on drug–drug interactions in older adults living with human immunodeficiency virus (HIV)
Linfield, R. Y., Nguyen, N. N., Laprade, O. H., Holodniy, M., & Chary, A. (2024) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2024.2350968 · Cited by 12 · see citing works
Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention
Fitch, K. V., Zanni, M. V., Manne‐Goehler, J., Diggs, M. R., Gattu, A. K., Currier, J. S., Bloomfield, G. S., Hsiao, C.-B., Gupta, S. K., Aberg, J. A., et al. (2024) · Annals of Internal Medicine · doi:10.7326/annals-24-00944 · Cited by 9 · see citing works
High concordance between chart review adjudication and electronic medical record data to identify prevalent and incident diabetes mellitus among persons with and without HIV
McGinnis, K. A., Justice, A. C., Bailin, S., Wellons, M., Freiberg, M. S., & Koethe, J. R. (2020) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5111 · Cited by 9 · see citing works
KIDNEY DISEASE IN THE SETTING OF HIV INFECTION: CONCLUSIONS FROM A KIDNEY DISEASE: IMPROVING GLOBAL OUTCOMES (KDIGO) CONTROVERSIES CONFERENCE
Swanepoel, C. R., Atta, M. G., D’Agati, V. D., Estrella, M. M., Fogo, A. B., Naicker, S., Post, F. A., Wearne, N., Winkler, C. A., Cheung, M., et al. (2018) · Nephrology (Saint-Petersburg) · doi:10.24884/1561-6274-2018-22-6-84-100 · Cited by 9 · see citing works
Clinic-based diabetes screening at the time of HIV testing and associations with poor clinical outcomes in South Africa: a cohort study
Kubiak, R. W., Kratz, M., Motala, A. A., Galagan, S. R., Govere, S., Brown, E. R., Moosa, M. S., & Drain, P. K. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06473-1 · Cited by 9 · see citing works
Documento de consenso sobre alteraciones metabólicas y riesgo cardiovascular en pacientes con infección por el virus de la inmunodeficiencia humana
(GEAM), D. L. S. D. P. N. S. E. S. (. Y. D. G. D. E. D. S. (. G. D. E. D. G. D. E. S. A. M. (2014) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2014.06.006 · Cited by 8 · see citing works
Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors
Stefansson, S., Stefansson, L. A., Chung, S.-W., Ko, K., Kwon, H. H., & Ahn, S. N. (2012) · Journal of Nanotechnology · doi:10.1155/2012/371487 · Cited by 8 · see citing works
Advanced Glycation End Products Inhibit Both Infection and Transmission In Trans of HIV-1 from Monocyte-Derived Dendritic Cells to Autologous T Cells
Nasreddine, N., Borde, C., Gozlan, J., Bélec, L., Maréchal, V., & Hocini, H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0902517 · Cited by 8 · see citing works
HIV and type 2 diabetes: An evolving story
Daultrey, H. E., Levett, T. J., Oliver, N. S., Vera, J. H., & Chakera, A. J. (2023) · HIV Medicine · doi:10.1111/hiv.13595 · Cited by 7 · see citing works
Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels
Duran, L., Rodriguez, C. V., Drozd, D., Nance, R. M., Delaney, J. A., Burkholder, G., Mugavero, M. J., Willig, J. H., Warriner, A. H., Crane, P. K., et al. (2015) · AIDS Research and Treatment · doi:10.1155/2015/478750 · Cited by 7 · see citing works
Predictors of glycaemic control among HIV-positive veterans with diabetes
Davies, M. L., Johnson, M. D., Brown, J. N., Bryan, W. E., & Townsend, M. L. (2014) · International Journal of STD & AIDS · doi:10.1177/0956462414535207 · Cited by 7 · see citing works
Low-carbohydrate dietary pattern on glycemic outcomes trial (ADEPT) among individuals with elevated hemoglobin A1c: study protocol for a randomized controlled trial
DORANS, K. S., Bazzano, L., Qi, L., He, H., Appel, L. J., Samet, J. M., Chen, J., Mills, K. T., Nguyen, B. T., O’Brien, M. J., et al. (2021) · Trials · doi:10.1186/s13063-020-05001-x · Cited by 7 · see citing works
Should We Bury HbA1c?
Bovee, L. B., & Hirsch, I. B. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2024.0028 · Cited by 7 · see citing works
Arterial structure and function in Africans with HIV for > 5 years: longitudinal relationship with endothelial activation and cardiovascular risk markers
Phalane, E., Fourie, C. M. T., Schutte, A. E., Kruger, I. M., & Mels, C. M. C. (2021) · HIV Medicine · doi:10.1111/hiv.13111 · Cited by 6 · see citing works
Optimizing cardiometabolic risk in people living with human immunodeficiency virus: A deep dive into an important risk enhancer
Kobe, E. A., Thakkar, A., Matai, S., Akkaya, E., Pagidipati, N. J., McGarrah, R. W., Bloomfield, G. S., & Shah, N. P. (2024) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2024.100888 · Cited by 6 · see citing works
The effect of genetic variability on the correlation between blood glucose and glycated hemoglobin levels
Gloria‐Bottini, F., Antonacci, E., Cozzoli, E., Acetis, C. D., & Bottini, E. (2010) · Metabolism · doi:10.1016/j.metabol.2010.01.003 · Cited by 6 · see citing works
Coronary Artery Disease
Chavez, P., & Pan, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-10451-1_9 · Cited by 6 · see citing works
Diabetes and human immunodeficiency virus infection: Epidemiological, therapeutic aspects and patient experience
Traoré, Y., Bensghir, R., Ihbibane, F., OuladLashen, A., Sodqi, M., Marih, L., Chakib, A., & Elfilali, K. M. (2016) · La Presse Médicale · doi:10.1016/j.lpm.2015.06.019 · Cited by 6 · see citing works
Soluble Levels of Receptor for Advanced Glycation Endproducts (RAGE) and Progression of Atherosclerosis in Individuals Infected with Human Immunodeficiency Virus: ACTG NWCS 332
Danoff, A., Kendall, M. A., Currier, J. S., Kelesidis, T., Schmidt, A. M., & Aberg, J. A. (2016) · Inflammation · doi:10.1007/s10753-016-0367-6 · Cited by 6 · see citing works
Prevalence and risk factors of hypertension and diabetes among persons living with HIV in Zambia: results of a national facility‐based cross‐sectional survey
Mandyata, C., Sivile, S., Bosomprah, S., Somwe, P., Zyambo, C. M., Musukuma, M., Mweemba, A., Chavula, M. P., Sichilima, C., Bwembya, P. A., et al. (2025) · Journal of the International AIDS Society · doi:10.1002/jia2.70051 · Cited by 5 · see citing works
Position statement on the use of HbA1C assays for the diagnosis of diabetes mellitus
Amod, A. (2010) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2010.10872229 · Cited by 4 · see citing works
Type 2 diabetes in people living with HIV: epidemiology, mechanisms, sex differences and early-life determinants
Moreno-López, R., Lazaro-Martin, B., Díez, C., Navarro‐Gómez, M. L., & Tarancón‐Díez, L. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1734023 · Cited by 4 · see citing works
Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population
Castle, A. C., Hoeppner, S. S., Magodoro, I. M., Singh, U., Moosa, Y., Bassett, I. V., Wong, E. B., Siedner, M. J., & on behalf of the Vukuzazi Study Team (2023) · PLoS ONE · doi:10.1371/journal.pone.0282371 · Cited by 4 · see citing works

Glycated Haemoglobin in Diabetic Women with and without HIV Infection: Data from the Women's Interagency HIV Study
Glesby, M. J., Hoover, D. R., Shi, Q., Danoff, A., Howard, A. A., Tien, P. C., Merenstein, D., Cohen, M. H., Golub, E. T., DeHovitz, J. A., et al. (2009) · Antiviral Therapy · doi:10.3851/imp1557 · Cited by 46 · see citing works
Monitoring HIV-infected Patients with Diabetes: Hemoglobin A1c, Fructosamine, or Glucose?
Kim, S. Y., Friedmann, P., Seth, A., & Fleckman, A. M. (2014) · Clinical Medicine Insights Endocrinology and Diabetes · doi:10.4137/cmed.s19202 · Cited by 12 · see citing works
Inaccuracy of haemoglobin A1c among HIV-infected men: effects of CD4 cell count, antiretroviral therapies and haematological parameters
Slama, L., Palella, F. J., Abraham, A. G., Li, X., Vigouroux, C., Pialoux, G., Kingsley, L., Lake, J. E., Brown, T. T., Margolick, J. B., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku295 · Cited by 71 · see citing works
Inappropriately Low Glycated Hemoglobin Values and Hemolysis in HIV-Infected Patients
Diop, M.-E., Bastard, J., Meunier, N., Thévenet, S., Maachi, M., Capeau, J., Pialoux, G., & Vigouroux, C. (2006) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2006.22.1242 · Cited by 68 · see citing works
Correlation between plasma glucose and hemoglobin A1c in HIV-infected individuals receiving zidovudine and non-zidovudine containing antiretroviral therapy regimens
Saetang, T., Sriphrapradang, C., Phuphuakrat, A., & D, S. S. M. (2020) · HIV Research & Clinical Practice · doi:10.1080/25787489.2020.1766864 · Cited by 5 · see citing works

Authors: Kim, P. S., Woods, C., Georgoff, P., Crum, D., Rosenberg, A., Smith, M., & Hadigan, C.
Affiliations: MedStar Washington Hospital Center (US)
University of Pennsylvania (US)
National Institutes of Health (US)
Corresponding author: Hadigan, Colleen
ORCID: Kim, Peter S.
Woods, Christian
Georgoff, Patrick
Hadigan, Colleen
Venue: Diabetes Care
Publisher: American Diabetes Association
Published: 2009-06-05
Volume: 32
Issue: 9
Pages: 1591-1593
ISSN: 0149-5992 (ISSN-L)
1935-5548
DOI: 10.2337/dc09-0177
PMC: PMC2732167
OpenAlex: W1976959779
Cited by: 145
References: 13
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 15 · 2020: 13 · 2019: 10 · 2018: 13 · 2017: 6 · 2016: 11 · 2015: 6 · 2014: 7 · 2013: 2 · 2012: 8
FWCI: 9.80
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 4467 d)
Locations: Diabetes Care (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Pfizer
National Institutes of Health
Topics: Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: HbA1c, glycemia, HIV infection, type 2 diabetes, fasting hyperglycemia, nucleoside reverse transcriptase inhibitors, abacavir, mean corpuscular volume, fructosamine, haptoglobin, hemoglobin
MeSH terms: Blood Glucose, Cross-Sectional Studies, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Prospective Studies, HIV Infections, Multivariate Analysis

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A1C underestimates glycemia in HIV infection

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