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Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection

Allard, Robert, Leclerc, Pascale, Tremblay, Claude, Tannenbaum, Terry-Nan·2010·Diabetes Care

Abstract

OBJECTIVE: To confirm the existence of an increased risk of complications from influenza A (H1N1)p among patients with diabetes. RESEARCH DESIGN AND METHODS: Using data from an enhanced influenza surveillance project in Montreal, Canada, and age/sex-specific population estimates of diabetes prevalence, we estimated the risk of hospitalization among persons with diabetes. Comparing hospitalized patients admitted or not to an intensive care unit (ICU), we estimated the risk of ICU admission associated with diabetes, controlling for other patient characteristics. RESULTS: Among 239 hospitalized patients with PCR-confirmed influenza A (H1N1)p, 162 (68%) were interviewed, of whom 22 had diabetes, when 7.1 were expected (prevalence ratio 3.10 [95% CI 2.04–4.71]). The odds ratio for ICU admission was 4.29 (95% CI 1.29–14.3) among hospitalized patients with diabetes compared to those without. CONCLUSIONS: Diabetes triples the risk of hospitalization after influenza A (H1N1)p and quadruples the risk of ICU admission once hospitalized.

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Research works printed but not linked: 8

  1. Muller, 2005, Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus, Clin Infect Dis, 41, 281, 10.1086/431587 · DOI
  2. Valdez, 1999, Impact of diabetes mellitus on mortality associated with pneumonia and influenza among non-Hispanic black and white US adults, Am J Public Health, 89, 1715, 10.2105/AJPH.89.11.1715 · DOI
  3. Orzeck, 2007, Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes, Clin Ther, 29, 2246, 10.1016/j.clinthera.2007.10.001 · DOI
  4. Fiore, 2009, Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009, MMWR Recomm Rep, 58, 1
  5. National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 2009, Use of influenza A (H1N1) 2009 monovalent vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009, MMWR Recomm Rep, 58, 1
  6. Louie, 2009, Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California, JAMA, 302, 1896, 10.1001/jama.2009.1583 · DOI
  7. Trichopoulos, 1996, Epidemiology: Principles and methods
  8. Bertoni, 2001, Diabetes and the risk of infection-related mortality in the U.S, Diabetes Care, 24, 1044, 10.2337/diacare.24.6.1044 · DOI

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Metadata

Authors
Allard, R., Leclerc, P., Tremblay, C., & Tannenbaum, T.-N.
Affiliations
Public Health Department, Montreal Health and Social Services Agency, Montreal, Quebec, Canada;
Venue
Diabetes Care
Published
2010-07-01
Volume
33
Issue
7
Pages
1491-1493
ISSN
  • 0149-5992
  • 1935-5548
Cited by
297
References
2
Language
en

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CoChat. (2026). Citation check: Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection. https://app.cochat.ai/papers/10.2337/dc09-2215
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Allard, R., Leclerc, P., Tremblay, C., & Tannenbaum, T.-N. (2010). Diabetes and the Severity of Pandemic Influenza A (H1N1) Infection. Diabetes Care. https://doi.org/10.2337/dc09-2215