The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes
Open accessAbstract
OBJECTIVE: To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and β-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin sensitivity/resistance were measured using the Matsuda insulin sensitivity index for oral glucose tolerance tests (ISOGTT) and homeostasis model assessment of insulin resistance HOMA-IR. β-Cell function was determined using both the insulinogenic index (IGI) divided by HOMA-IR (IGI/IR) and the insulin secretion sensitivity index-2 (ISSI-2). RESULTS: Linear regression analyses indicated independent associations of 25(OH)D with ISOGTT and HOMA-IR (β = 0.004, P = 0.0003, and β = −0.003, P = 0.0072, respectively) and with IGI/IR and ISSI-2 (β = 0.004, P = 0.0286, and β = 0.003, P = 0.0011, respectively) after adjusting for sociodemographics, physical activity, supplement use, parathyroid hormone, and BMI. CONCLUSIONS: Vitamin D may play a role in the pathogenesis of type 2 diabetes, as 25(OH)D concentration was independently associated with both insulin sensitivity and β-cell function among individuals at risk of type 2 diabetes.
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Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
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Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
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Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
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Vitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
Vitamin D supplementation and prevention of type 2 diabetes
Pittas, A. G., Dawson-Hughes, B., Sheehan, P., Ware, J. H., Knowler, W. C., Aroda, V. R., Brodsky, I., Ceglia, L., Chadha, C., Chatterjee, R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1900906 · Cited by 673
The roles of vitamin D in skeletal muscle: form, function, and metabolism
Girgis, C. M., Clifton-Bligh, R. J., Hamrick, M. W., Holick, M. F., & Gunton, J. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1012 · Cited by 567
Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence
Zelber-Sagi, S. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i29.3377 · Cited by 300
Antidiabetic phytoconstituents and their mode of action on metabolic pathways
Bharti, S. K., Krishnan, S., Kumar, A., & Kumar, A. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818755019 · Cited by 222
Metadata
- Authors
- Kayaniyil, S., Vieth, R., Retnakaran, R., Knight, J. A., Qi, Y., Gerstein, H. C., Perkins, B. A., Harris, S. B., Zinman, B., & Hanley, A. J.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-03-09
- Volume
- 33
- Issue
- 6
- Pages
- 1379-1381
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2132605013
- Cited by
- 346
- References
- 16
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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