The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Evaluation of proposed oral disposition index measures in relation to the actual disposition index
Abstract
Aims While the disposition index provides a useful measure of B‐cell function, its calculation requires the performance of a frequently sampled intravenous glucose tolerance test (FSIVGTT). Recently, the demonstration of a hyperbolic relationship between indices of insulin secretion and insulin sensitivity derived from the oral glucose tolerance test (OGTT) has led to the introduction of two novel OGTT‐based measures of B‐cell function analogous to the disposition index: (i) the insulin secretion‐sensitivity index‐2 (ISSI‐2) (defined as the ratio of the area‐under‐the‐insulin‐curve to the area‐under‐the‐glucose curve, multiplied by the Matsuda index) and (ii) insulinogenic index (IGI)/fasting insulin. However, neither of these two measures has been directly compared with the disposition index. Methods Two hundred and thirteen non‐diabetic children (122 boys, 91 girls) underwent both OGTT and FSIVGTT, allowing for the calculation of ISSI‐2, IGI/fasting insulin and the disposition index. Results ISS1‐2 and IGI/fasting insulin were strongly correlated with each other (r = 0.82, P < 0.0001). Both measures correlated with the disposition index, with ISSI‐2 showing a modestly stronger association (ISSI‐2: r = 0.24, P = 0.0003; IGI/fasting insulin: r = 0.21, P = 0.0022). Standardized linear regression analyses confirmed that the relationship between log ISSI‐2 and the disposition index (standardized regression coefficient = 0.224, P = 0.001) was stronger than that between log IGI/fasting insulin and the disposition index (standardized regression coefficient = 0.166, P = 0.015). Conclusions The OGTT‐derived measures ISSI‐2 and IGI/fasting insulin exhibit modest correlations with the disposition index. These relationships require further assessment in other patient populations.
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Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test
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Kayaniyil, S., Vieth, R., Retnakaran, R., Knight, J. A., Qi, Y., Gerstein, H. C., Perkins, B. A., Harris, S. B., Zinman, B., & Hanley, A. J. (2010) · Diabetes Care · doi:10.2337/dc09-2321 · Cited by 346
Self-citationZinman, B., Harris, S. B., Neuman, J., Gerstein, H. C., Retnakaran, R. R., Raboud, J., Qi, Y., & Hanley, A. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60746-5 · Cited by 235
Self-citationIncreased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients
Hu, H., Sun, W., Yu, S., Hong, X., Qian, W., Tang, B., Wang, D., Yang, L., Wang, J., Mao, C., et al. (2014) · Diabetes Care · doi:10.2337/dc14-0602 · Cited by 171
Fetal Sex and Maternal Risk of Gestational Diabetes Mellitus: The Impact of Having a Boy
Retnakaran, R., Kramer, C. K., Ye, C., Kew, S., Hanley, A. J., Connelly, P. W., Sermer, M., & Zinman, B. (2015) · Diabetes Care · doi:10.2337/dc14-2551 · Cited by 166
Self-citationDisposition Index, Glucose Effectiveness, and Conversion to Type 2 Diabetes
Lorenzo, C., Wagenknecht, L. E., Rewers, M. J., Karter, A. J., Bergman, R. N., Hanley, A. J. G., & Haffner, S. M. (2010) · Diabetes Care · doi:10.2337/dc10-0165 · Cited by 145
Metadata
- Authors
- Retnakaran, R., Qi, Y., Goran, M. I., & Hamilton, J. K.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2009-11-24
- Volume
- 26
- Issue
- 12
- Pages
- 1198-1203
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2119878811
- Cited by
- 320
- References
- 14
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
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