Sex Steroids Affect Triglyceride Handling, Glucose-Dependent Insulinotropic Polypeptide, and Insulin Sensitivity
Open accessAbstract
OBJECTIVE: To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. RESEARCH DESIGN AND METHODS: A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E2) and increase testosterone (group T, n = 10) versus letrozole plus E2 patches to lower T and raise E2 (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period. RESULTS: Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E. CONCLUSIONS: In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
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Concomitantly increasing testosterone and decreasing estradiol levels has positive effects on postprandial triglyceride handling and insulin sensitivity.
“Concomitantly increasing testosterone and decreasing estradiol (E2) levels had positive effects on both postprandial triglyceride handling and insulin sensitivity in elaborate clamp models during manipulation of these serum sex steroid levels (50).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [50]
An improvement in insulin sensitivity upon testosterone administration results in reduced fasting glucose and insulin levels within a single week.
“An improvement in insulin sensitivity upon testosterone administration resulted in reduced fasting glucose and insulin levels within a single week (50)”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [50]
The interplay between insulin sensitivity, triglyceride levels, and androgens occurs within a week and is not facilitated by changes in body composition alone.
“Recently, it has been demonstrated that the interplay between insulin sensitivity, triglyceride levels, and androgens is practically immediate, as it occurs within a week, and is not facilitated by changes in body composition alone.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [50]
Testosterone administration increases the response of postprandial glucose-dependent insulinotropic polypeptide (GIP) release.
“Furthermore, the aforementioned intervention increased the response of postprandial glucose-dependent insulinotropic polypeptide (GIP) release (50).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [50]
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- Authors
- Lapauw, B., Ouwens, M., ′t Hart, L. M., Wuyts, B., Holst, J. J., T'Sjoen, G., Kaufman, J.-M., & Ruige, J. B.
- Affiliations
- Ghent University Hospital (BE)
- Deutsches Diabetes Zentrum, Institut für Klinische Biochemie und Pathobiochemie, Düsseldorf, Germany;
- Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands;
- University of Copenhagen (DK)
- Corresponding author
- Ruige, Johannes B.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2010-05-18
- Volume
- 33
- Issue
- 8
- Pages
- 1831-1833
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC2909071
- OpenAlex
- W2126074620
- Cited by
- 32
- References
- 15
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 2 · 2019: 5 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 3 · 2012: 6
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- sex steroids, estradiol, testosterone, letrozole, aromatase inhibitors, estradiol patch, postprandial triglyceride response, glucose-dependent insulinotropic polypeptide, insulin sensitivity, hyperinsulinemic-euglycemic clamp, mixed meal, young men
- MeSH terms
- Letrozole, Adult, Estradiol, Fasting, Gastric Inhibitory Polypeptide, Humans, Insulin Resistance, Male, Nitriles, Testosterone, Triazoles, Triglycerides, Postprandial Period, Aromatase Inhibitors, Lipid Metabolism, Young Adult
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