The Effect of Walking on Postprandial Glycemic Excursion in Patients With Type 1 Diabetes and Healthy People
Open accessAbstract
OBJECTIVE: Physical activity (PA), even at low intensity, promotes health and improves hyperglycemia. However, the effect of low-intensity PA captured with accelerometery on glucose variability in healthy individuals and patients with type 1 diabetes has not been examined. Quantifying the effects of PA on glycemic variability would improve artificial endocrine pancreas (AEP) algorithms. RESEARCH DESIGN AND METHODS: We studied 12 healthy control subjects (five males, 37.7 ± 13.7 years of age) and 12 patients with type 1 diabetes (five males, 37.4 ± 14.2 years of age) for 88 h. Participants performed PA approximating a threefold increase over their basal metabolic rate. PA was captured using a PA-monitoring system, and interstitial fluid glucose concentrations were captured with continuous glucose monitors. In random order, one meal per day was followed by inactivity, and the other meals were followed by walking. Glucose and PA data for a total of 216 meals were analyzed from 30 min prior to meal ingestion to 270 min postmeal. RESULTS: In healthy subjects, the incremental glucose area under the curve was 4.5 mmol/L/270 min for meals followed by walking, whereas it was 9.6 mmol/L/270 min (P = 0.022) for meals followed by inactivity. The corresponding glucose excursions for those with type 1 diabetes were 7.5 mmol/L/270 min and 18.4 mmol/L/270 min, respectively (P < 0.001). CONCLUSIONS: Walking significantly impacts postprandial glucose excursions in healthy populations and in those with type 1 diabetes. AEP algorithms incorporating PA may enhance tight glycemic control end points.
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Physical activity of any intensity modulates glucose control and postprandial glucose excursions.
“Since physical activity of any intensity modulates glucose control and postprandial glucose excursions, 62,63”
From Developing the UVA/Padova Type 1 Diabetes Simulator: Modeling, Validation, Refinements, and Utility (2023) · cites this paper as [63]
The Conclusions (page not supplied) report that low-grade activity after meals can lower postprandial glucose excursions, and discuss glucose-lowering effects of light and moderate activity. The paper does not establish the claim for physical activity of any intensity. (LLM, conf=0.87)
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Cites
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,320 · see citing works
The Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755 · see citing works
Follow-up report on the diagnosis of diabetes mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3160 · Cited by 3,784 · see citing works
Taylor, R. S., Brown, A., Ebrahim, S., Jolliffe, J., Noorani, H., Rees, K., Skidmore, B., Stone, J. A., Thompson, D. R., & Oldridge, N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.009 · Cited by 2,239 · see citing works
Wen, C. P., Wai, J. P. M., Tsai, M. K., Yang, Y. C., Cheng, T. Y. D., Lee, M.-C., Chan, H. T., Tsao, C. K., Tsai, S. P., & Wu, X. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60749-6 · Cited by 1,908 · see citing works
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
Dunstan, D. W., Kingwell, B. A., Larsen, R., Healy, G. N., Cerin, E., Hamilton, M. T., Shaw, J. E., Bertovic, D. A., Zimmet, P. Z., Salmon, J., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1931 · Cited by 1,203 · see citing works
Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes
Bergenstal, R. M., Tamborlane, W. V., Ahmann, A., Buse, J. B., Dailey, G., Davis, S. N., Joyce, C., Peoples, T., Perkins, B. A., Welsh, J. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1002853 · Cited by 894 · see citing works
Interindividual variation in posture allocation: possible role in human obesity
Levine, J. A., Lanningham-Foster, L. M., McCrady, S. K., Krizan, A. C., Olson, L. R., Kane, P. H., Jensen, M. D., & Clark, M. M. (2005) · Science · doi:10.1126/science.1106561 · Cited by 705 · see citing works
Self-citationArtificial Pancreas: Past, Present, Future
Cobelli, C., Renard, E., & Kovatchev, B. (2011) · Diabetes · doi:10.2337/db11-0654 · Cited by 600 · see citing works
Self-citationFear of hypoglycemia: quantification, validation, and utilization
Cox, D. J., Irvine, A., Gonder-Frederick, L., Nowacek, G., & Butterfield, J. (1987) · Diabetes Care · doi:10.2337/diacare.10.5.617 · Cited by 579 · see citing works
Kovatchev, B. P., Cox, D. J., Gonder-Frederick, L. A., Young-Hyman, D. L., Schlundt, D. G., & Clarke, W. L. (1998) · Diabetes Care · doi:10.2337/diacare.21.11.1870 · Cited by 309 · see citing works
Diurnal pattern to insulin secretion and insulin action in healthy individuals
Saad, A., Dalla Man, C., Nandy, D. K., Levine, J. A., Bharucha, A. E., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., Kudva, Y. C., et al. (2012) · Diabetes · doi:10.2337/db11-1478 · Cited by 297 · see citing works
Self-citationStephens, B. R., Granados, K. E., Zderic, T. W., Hamilton, M. T., & Braun, B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.08.014 · Cited by 233 · see citing works
Use of a novel triple-tracer approach to assess postprandial glucose metabolism
Basu, R., Di Camillo, B., Toffolo, G., Basu, A., Shah, P., Vella, A., Rizza, R., & Cobelli, C. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2001 · Cited by 189 · see citing works
Self-citationPreventing Stroke in Patients With Atrial Fibrillation
Ezekowitz, M. D. (1999) · JAMA · doi:10.1001/jama.281.19.1830 · Cited by 168 · see citing works
Physical Activity into the Meal Glucose—Insulin Model of Type 1 Diabetes: In Silico Studies
Man, C. D., Breton, M., & Cobelli, C. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300107 · Cited by 132 · see citing works
Self-citationOrchard, T. J. (1996) · Annals of Medicine · doi:10.3109/07853899608999089 · Cited by 95 · see citing works
Physical Activity—The Major Unaccounted Impediment to Closed Loop Control
Breton, M. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200127 · Cited by 77 · see citing works
Kovatchev, B. P., Cox, D. J., Farhy, L. S., Straume, M., Gonder-Frederick, L. A., & Clarke, W. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.11.6999 · Cited by 76 · see citing works
Understanding Error Grid Analysis
Cox, D. J., Gonder-Frederick, L. A., Kovatchev, B. P., Julian, D. M., & Clarke, W. L. (1997) · Diabetes Care · doi:10.2337/diacare.20.6.911 · Cited by 73 · see citing works
Dvorak, R. V., Tchernof, A., Starling, R. D., Ades, P. A., DiPietro, L., & Poehlman, É. T. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6432 · Cited by 60 · see citing works
Kovatchev, B. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.11.4287 · Cited by 59 · see citing works
Short, K. R., Pratt, L. V., & Teague, A. M. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/278678 · Cited by 37 · see citing works
Conover, C. A., Mason, M. A., Levine, J. A., & Novak, C. M. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0179 · Cited by 27 · see citing works
Self-citationAndersen, E., & Høstmark, A. T. (2007) · The Journal of Strength and Conditioning Research · doi:10.1519/r-20105.1 · Cited by 26 · see citing works
Lazzer, S., Boirie, Y., Bitar, A., et al. (2005) · PubMed · Cited by 18 · see citing works
Is glycemic variability important to assessing antidiabetes therapies?
Kovatchev, B. P. (2006) · Current Diabetes Reports · doi:10.1007/s11892-006-0005-z · Cited by 11 · see citing works
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Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991 · see citing works
Sedentary behavior as a mediator of type 2 diabetes
Hamilton, M. T., Hamilton, D. G., & Zderic, T. W. (2014) · Medicine and Sport Science · doi:10.1159/000357332 · Cited by 185 · see citing works
Diurnal Pattern of Insulin Action in Type 1 Diabetes
Hinshaw, L., Dalla Man, C., Nandy, D. K., Saad, A., Bharucha, A. E., Levine, J. A., Rizza, R. A., Basu, R., Carter, R. E., Cobelli, C., et al. (2013) · Diabetes · doi:10.2337/db12-1759 · Cited by 125 · see citing works
Self-citationCircadian Variability of Insulin Sensitivity: Physiological Input for In Silico Artificial Pancreas
Visentin, R., Dalla Man, C., Kudva, Y. C., Basu, A., & Cobelli, C. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0192 · Cited by 113 · see citing works
Self-citationThe Effect of Timing of Exercise and Eating on Postprandial Response in Adults: A Systematic Review
Aqeel, M., Forster, A., Richards, E., Hennessy, E., McGowan, B., Bhadra, A., Guo, J., Gelfand, S., Delp, E., & Eicher-Miller, H. (2020) · Nutrients · doi:10.3390/nu12010221 · Cited by 54 · see citing works
Leibel, R. L., Seeley, R. J., Darsow, T., Berg, E. G., Smith, S. R., & Ratner, R. (2015) · Diabetes · doi:10.2337/db15-0004 · Cited by 52 · see citing works
Postprandial glucose fluxes and insulin sensitivity during exercise: A study in healthy individuals
Schiavon, M., Hinshaw, L., Mallad, A., Man, C. D., Sparacino, G., Johnson, M., Carter, R., Basu, R., Kudva, Y., Cobelli, C., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00182.2013 · Cited by 45 · see citing works
Self-citationDeveloping the UVA/Padova Type 1 Diabetes Simulator: Modeling, Validation, Refinements, and Utility
Cobelli, C., & Kovatchev, B. (2023) · Journal of Diabetes Science and Technology · doi:10.1177/19322968231195081 · Cited by 46 · see citing works
Self-citation
- Authors
- Manohar, C., Levine, J. A., Nandy, D. K., Saad, A., Dalla Man, C., McCrady-Spitzer, S. K., Basu, R., Cobelli, C., Carter, R. E., Basu, A., & Kudva, Y. C.
- Affiliations
- Case Western Reserve University (US)
- University of Minnesota Rochester (US)
- Division of Endocrinology and Metabolism, Rochester, Minnesota
- Department of Information Engineering, University of Padua, Padua, Italy
- University of Padua (IT)
- Mayo Clinic (US)
- Corresponding author
- Kudva, Yogish C.
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2012-11-14
- Volume
- 35
- Issue
- 12
- Pages
- 2493-2499
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3507567
- OpenAlex
- W2146467643
- Cited by
- 89
- References
- 27
- Citations by year
- 2024: 8 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 7
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK085516, R01DK085516)
- National Center for Research Resources (UL1RR024150)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- walking, physical activity, postprandial glycemic excursions, type 1 diabetes, glycemic variability, artificial pancreas, continuous glucose monitoring, interstitial glucose, light physical activity, tight glycemic control
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 1, Female, Humans, Male, Middle Aged, Walking, Postprandial Period, Young Adult
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