Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients
Open accessAbstract
OBJECTIVE: To evaluate the effects of qualitative dietary changes and the interaction with aerobic exercise training on liver fat content independent of weight loss in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: With use of a factorial 2 × 2 randomized parallel-group design, 37 men and 8 women, aged 35-70 years, with type 2 diabetes in satisfactory blood glucose control on diet or diet plus metformin treatment were assigned to one of the following groups for an 8-week period: 1) high-carbohydrate/high-fiber/low-glycemic index diet (CHO/fiber group), 2) high-MUFA diet (MUFA group), 3) high-carbohydrate/high-fiber/low-glycemic index diet plus physical activity program (CHO/fiber+Ex group), and 4) high-MUFA diet plus physical activity program (MUFA+Ex group). Before and after intervention, hepatic fat content was measured by (1)H NMR. RESULTS: Dietary compliance was optimal and body weight remained stable in all groups. Liver fat content decreased more in MUFA (-29%) and MUFA+Ex (-25%) groups than in CHO/fiber (-4%) and CHO/fiber+Ex groups (-6%). Two-way repeated-measures ANOVA, including baseline values as covariate, showed a significant effect on liver fat content for diet (P = 0.006), with no effects for exercise training (P = 0.789) or diet-exercise interaction (P = 0.712). CONCLUSIONS: An isocaloric diet enriched in MUFA compared with a diet higher in carbohydrate and fiber was associated with a clinically relevant reduction of hepatic fat content in type 2 diabetic patients independent of an aerobic training program and should be considered for the nutritional management of hepatic steatosis in people with type 2 diabetes.
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POo contains a high proportion of unsaturated fatty acids (54% MUFAs, 10% PUFAs), which have been reported to increase β-oxidation rates and reduce liver fat.
“POo contains a high proportion of unsaturated fatty acids (54% MUFAs, 10% PUFAs) (Table 1), which have been reported to increase β -oxidation rates (37, 39) and reduce liver fat (40).”
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- Authors
- Bozzetto, L., Prinster, A., Annuzzi, G., Costagliola, L., Mangione, A., Vitelli, A., Mazzarella, R., Longobardo, M., Mancini, M., Vigorito, C., Riccardi, G., & Rivellese, A. A.
- Affiliations
- Federico II University Hospital (IT)
- Institute of Biostructure and Bioimaging (IT)
- University of Naples Federico II (IT)
- Corresponding author
- Rivellese, Angela A.
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2012-06-12
- Volume
- 35
- Issue
- 7
- Pages
- 1429-1435
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC3379578
- OpenAlex
- W1965542427
- Cited by
- 227
- References
- 41
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 17 · 2023: 15 · 2022: 20 · 2021: 19 · 2020: 25 · 2019: 22 · 2018: 22 · 2017: 20 · 2016: 17 · 2015: 6 · 2014: 13 · 2013: 11 · 2012: 4
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Diabetes Care (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- FP7 Food, Agriculture and Fisheries, Biotechnology
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, hepatic steatosis, liver fat, monounsaturated fatty acids, dietary fat composition, isocaloric diet, aerobic exercise training, dietary fiber, low glycemic index diet, metformin
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Fats, Fatty Acids, Monounsaturated, Fatty Liver, Female, Humans, Liver, Male, Metformin, Middle Aged, Exercise
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