Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)
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UNLABELLED: Although lifestyle interventions are considered the first-line therapy for nonalcoholic fatty liver disease (NAFLD), which is extremely common in people with type 2 diabetes, no intervention studies have compared the effects of aerobic (AER) or resistance (RES) training on hepatic fat content in type 2 diabetic subjects with NAFLD. In this randomized controlled trial, we compared the 4-month effects of either AER or RES training on insulin sensitivity (by hyperinsulinemic euglycemic clamp), body composition (by dual-energy X-ray absorptiometry), as well as hepatic fat content and visceral (VAT), superficial (SSAT), and deep (DSAT) subcutaneous abdominal adipose tissue (all quantified by an in-opposed-phase magnetic resonance imaging technique) in 31 sedentary adults with type 2 diabetes and NAFLD. After training, hepatic fat content was markedly reduced (P < 0.001), to a similar extent, in both the AER and the RES training groups (mean relative reduction from baseline [95% confidence interval] -32.8% [-58.20 to -7.52] versus -25.9% [-50.92 to -0.94], respectively). Additionally, hepatic steatosis (defined as hepatic fat content >5.56%) disappeared in about one-quarter of the patients in each intervention group (23.1% in the AER group and 23.5% in the RES group). Insulin sensitivity during euglycemic clamp was increased, whereas total body fat mass, VAT, SSAT, and hemoglobin A1c were reduced comparably in both intervention groups. CONCLUSION: This is the first randomized controlled study to demonstrate that resistance training and aerobic training are equally effective in reducing hepatic fat content among type 2 diabetic patients with NAFLD.
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Based on seven protocols from seven studies, a reduction in hepatic steatosis was observed in 85.7% of resistance exercise protocols, including five randomized controlled trials.
“Based on seven protocols from seven studies, a reduction in hepatic steatosis was observed in 85.7% of the protocols, including five randomized controlled trials (76–82).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [78]
MR spectroscopy showed a decrease in intrahepatic lipid levels in three studies (13%; 3%; and 25% reduction from baseline).
“MR spectroscopy showed a decrease in intrahepatic lipid levels in three studies (13%; 3%; and 25% reduction from baseline (76–78)).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [78]
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- Authors
- Bacchi, E., Negri, C., Targher, G., Faccioli, N., Lanza, M., Zoppini, G., Zanolin, E., Schena, F., Bonora, E., & Moghetti, P.
- Affiliations
- University of Verona (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Corresponding author
- Moghetti, Paolo
- ORCID
- Venue
- Hepatology
- Published
- 2013-10
- Volume
- 58
- Issue
- 4
- Pages
- 1287-1295
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2053915733
- Cited by
- 350
- References
- 32
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 23 · 2023: 33 · 2022: 23 · 2021: 41 · 2020: 34 · 2019: 19 · 2018: 23 · 2017: 31 · 2016: 32 · 2015: 24 · 2014: 24 · 2013: 6
- FWCI
- 20.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Università degli Studi di Verona
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- resistance training, aerobic exercise, non-alcoholic fatty liver disease, type 2 diabetes, hepatic fat content, hepatic steatosis, insulin sensitivity, visceral adipose tissue, subcutaneous abdominal fat, body composition, lifestyle intervention
- MeSH terms
- Body Composition, Diabetes Mellitus, Type 2, Fatty Liver, Female, Humans, Insulin Resistance, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Exercise, Comorbidity, Treatment Outcome, Subcutaneous Fat, Lipid Metabolism, Resistance Training, Non-alcoholic Fatty Liver Disease
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