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Cited by 168

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

Gianatti, Emily J., Dupuis, Philippe, Hoermann, Rudolf, Strauss, Boyd J., Wentworth, John M., Zajac, Jeffrey D., Grossmann, Mathis·2014·Diabetes Care
DOI 10.2337/dc13-2845
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Abstract

OBJECTIVE: To determine whether testosterone therapy improves glucose metabolism in men with type 2 diabetes (T2D) and lowered testosterone. RESEARCH DESIGN AND METHODS: We conducted a randomized, double-blind, parallel, placebo-controlled trial in 88 men with T2D, aged 35–70 years with an HbA1c ≤8.5% (69 mmol/mol), and a total testosterone level, measured by immunoassay, of ≤12.0 nmol/L (346 ng/dL). Participants were randomly assigned to 40 weeks of intramuscular testosterone undecanoate (n = 45) or matching placebo (n = 43). All study subjects were included in the primary analysis. Seven men assigned to testosterone and six men receiving placebo did not complete the study. Main outcome measures were insulin resistance by homeostatic model assessment (HOMA-IR, primary outcome) and glycemic control by HbA1c (secondary outcome). RESULTS: Testosterone therapy did not improve insulin resistance (mean adjusted difference [MAD] for HOMA-IR compared with placebo −0.08 [95% CI −0.31 to 0.47; P = 0.23]) or glycemic control (MAD HbA1c 0.36% [0.0–0.7]; P = 0.05), despite a decrease in fat mass (MAD −2.38 kg [−3.10 to −1.66]; P < 0.001) and an increase in lean mass (MAD 2.08 kg [1.52–2.64]; P < 0.001). Testosterone therapy reduced subcutaneous (MAD −320 cm3 [−477 to −163]; P < 0.001) but not visceral abdominal adipose tissue (MAD 140 cm3 [−89 to 369]; P = 0.90). CONCLUSIONS: Testosterone therapy does not improve glucose metabolism or visceral adiposity in obese men with moderately controlled T2D and modest reductions in circulating testosterone levels typical for men with T2D.

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Show all 24 references

Research works printed but not linked: 14

  1. Ding, 2006, Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis, JAMA, 295, 1288, 10.1001/jama.295.11.1288 · DOI · Paper page
  2. Singh, 2003, Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway, Endocrinology, 144, 5081, 10.1210/en.2003-0741 · DOI · Paper page
  3. Hamilton, 2011, Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy, Clin Endocrinol (Oxf), 74, 377, 10.1111/j.1365-2265.2010.03942.x · DOI · Paper page
  4. Isidori, 2005, Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis, Clin Endocrinol (Oxf), 63, 280, 10.1111/j.1365-2265.2005.02339.x · DOI · Paper page
  5. Travison, 2007, The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men, J Clin Endocrinol Metab, 92, 549, 10.1210/jc.2006-1859 · DOI · Paper page
  6. Harwood, 2009, Development and validation of a sensitive liquid chromatography-tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization, Clin Chim Acta, 409, 78, 10.1016/j.cca.2009.09.003 · DOI · Paper page
  7. Mari, 2001, A model-based method for assessing insulin sensitivity from the oral glucose tolerance test, Diabetes Care, 24, 539, 10.2337/diacare.24.3.539 · DOI · Paper page
  8. Chan, 2005, Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism, Clin Chem, 51, 578, 10.1373/clinchem.2004.045120 · DOI
  9. Singh, 2002, The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men, J Clin Endocrinol Metab, 87, 136, 10.1210/jcem.87.1.8172 · doi:10.1210/jcem.87.1.8172 · Paper page
  10. Okauchi, 2009, Changes in serum adiponectin concentrations correlate with changes in BMI, waist circumference, and estimated visceral fat area in middle-aged general population, Diabetes Care, 32, e122, 10.2337/dc09-1130 · DOI
  11. Gopal, 2010, Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus, Endocr Pract, 16, 570, 10.4158/EP09355.OR · DOI
  12. Kalinchenko, 2010, Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study, Clin Endocrinol (Oxf), 73, 602, 10.1111/j.1365-2265.2010.03845.x · DOI · Paper page
  13. Matsuda, 1999, Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp, Diabetes Care, 22, 1462, 10.2337/diacare.22.9.1462 · DOI · Paper page
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Metadata

Authors
Gianatti, E. J., Dupuis, P., Hoermann, R., Strauss, B. J., Wentworth, J. M., Zajac, J. D., & Grossmann, M.
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2014-07-12
Volume
37
Issue
8
Pages
2098-2107
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc13-2845
OpenAlex
W2135665407
Cited by
168
References
24
FWCI
12.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial. https://app.cochat.ai/papers/10.2337/dc13-2845
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Gianatti, E. J., Dupuis, P., Hoermann, R., Strauss, B. J., Wentworth, J. M., Zajac, J. D., & Grossmann, M. (2014). Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care. https://doi.org/10.2337/dc13-2845

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