Enumerating β-Cells in Whole Human Islets: Sex Differences and Associations With Clinical Outcomes After Islet Transplantation
Open accessAbstract
Islet transplantation is an experimental therapy for type 1 diabetes. Though it is increasingly successful, limitations include unpredictable declines in islet graft function (1). There is still inadequate knowledge of specific human islet characteristics that predispose to successful and durable islet graft function and what types of donors are more likely to have islets with these beneficial traits. The relationship between the composition of dissociated human islets (as opposed to whole islets) and transplant outcomes has been studied (2), with a positive association between recipients’ acute insulin response to glucose (AIRg) posttransplant and number of pancreatic ductal cells in the preparation (a positive association with number of β-cells approached significance). However, as dissociation inherently damages islets, β-cells enumerated after dissociation may no longer reflect the number of β-cells within whole islets ultimately transplanted. Using an epidemiological approach, we therefore investigated 1 ) the independent association of the β-cell composition of transplanted whole human islets with recipient outcomes and 2 ) the donor …
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The percentage of β-cells in female pancreatic islets appeared to exceed that of male islets (6% more β-cells on average in females).
“More specifically, according to a study conducted on biopsies of human pancreases, the percentage of β-cells in the female pancreatic islets appeared to exceed that of the male islets (6% more β-cells on average in females) [81].”
From Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care (2022) · cites this paper as [81]
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- Authors
- Marchese, E., Rodeghier, C., Monson, R. S., McCracken, B., Shi, T., Schrock, W., Martellotto, J., Oberholzer, J., & Danielson, K. K.
- Affiliations
- University of Illinois Chicago (US)
- Division of Transplant Surgery, University of Illinois at Chicago, Chicago, IL
- Corresponding author
- Danielson, Kirstie K.
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2015-09-17
- Volume
- 38
- Issue
- 11
- Pages
- e176-e177
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC4613918
- OpenAlex
- W2177887995
- Cited by
- 41
- References
- 4
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 2 · 2019: 1 · 2018: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Efroymson Foundation
- Chicago Diabetes Project
- Christopher Foundation
- Dr. Scholl Foundation
- College of Medicine at the University of Illinois at Chicago
- Washington Square Health Foundation
- University of Illinois at Chicago Craig Fellowship for medical student research
- National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Office of Research on Women’s Health (K12HD055892)
- National Center for Research Resources (U42RR023245)
- University of Illinois at Chicago Honors College grant for undergraduate research
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- islet transplantation, type 1 diabetes, sex differences, islet graft function, acute insulin response, pancreatic ductal cells, clinical outcomes
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