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Cited by 405Physical Activity and HealthDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities

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Dempsey, Paddy C., Larsen, Robyn N., Sethi, Parneet, Sacre, Julian W., Straznicky, Nora E., Cohen, Neale D., Cerin, Ester, Lambert, Gavin W., Owen, Neville, Kingwell, Bronwyn A., Dunstan, David W.·2016·Diabetes Care
DOI 10.2337/dc15-2336
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Abstract

OBJECTIVE: To determine whether interrupting prolonged sitting with brief bouts of light-intensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 ± 6 years old) underwent the following 8-h conditions on three separate days (with 6–14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km · h−1) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS: Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol · h · L−1 [95% CI 20.4–28.0] vs. LW 14.8 [11.0–18.6] and SRA 14.7 [10.9–18.5]), insulin (SIT 3,293 pmol · h · L−1 [2,887–3,700] vs. LW 2,104 [1,696–2,511] and SRA 2,066 [1,660–2,473]), and C-peptide (SIT 15,641 pmol · h · L−1 [14,353–16,929] vs. LW 11,504 [10,209–12,799] and SRA 11,012 [9,723–12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW (SIT 4.8 mmol · h · L−1 [3.6–6.0] vs. LW 4.0 [2.8–5.1] and SRA 2.9 [1.7–4.1]). CONCLUSIONS: Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.

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Authors
Dempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., & Dunstan, D. W.
Affiliations
Baker Heart and Diabetes Institute (AU)
Corresponding author
Dempsey, Paddy C.
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2016-04-13
Volume
39
Issue
6
Pages
964-972
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc15-2336
OpenAlex
W2337858743
Cited by
405
References
43
Citations by year
2026: 28 · 2025: 28 · 2024: 37 · 2023: 44 · 2022: 51 · 2021: 48 · 2020: 45 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 12
FWCI
33.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Funders
National Health and Medical Research Council (1081734)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, prolonged sitting, sedentary behavior, postprandial blood glucose, insulin, C-peptide, triglycerides, cardiometabolic risk, glucose metabolism, overweight and obesity, physical activity breaks, calf raise, half squat
MeSH terms
Aged, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Insulin, Male, Middle Aged, Obesity, Posture, Triglycerides, Walking, Cross-Over Studies, Postprandial Period, Overweight, Resistance Training, Sedentary Behavior

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