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Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
Open accessAbstract
OBJECTIVE: To determine whether interrupting prolonged sitting with brief bouts of light-intensity walking (LW) or simple resistance activities (SRA) improves postprandial cardiometabolic risk markers in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men 62 ± 6 years old) underwent the following 8-h conditions on three separate days (with 6–14 days washout): uninterrupted sitting (control) (SIT), sitting plus 3-min bouts of LW (3.2 km · h−1) every 30 min, and sitting plus 3-min bouts of SRA (half-squats, calf raises, gluteal contractions, and knee raises) every 30 min. Standardized meals were consumed during each condition. Incremental areas under the curve (iAUCs) for glucose, insulin, C-peptide, and triglycerides were compared between conditions. RESULTS: Compared with SIT, both activity-break conditions significantly attenuated iAUCs for glucose (SIT mean 24.2 mmol · h · L−1 [95% CI 20.4–28.0] vs. LW 14.8 [11.0–18.6] and SRA 14.7 [10.9–18.5]), insulin (SIT 3,293 pmol · h · L−1 [2,887–3,700] vs. LW 2,104 [1,696–2,511] and SRA 2,066 [1,660–2,473]), and C-peptide (SIT 15,641 pmol · h · L−1 [14,353–16,929] vs. LW 11,504 [10,209–12,799] and SRA 11,012 [9,723–12,301]) (all P < 0.001). The iAUC for triglycerides was significantly attenuated for SRA (P < 0.001) but not for LW (SIT 4.8 mmol · h · L−1 [3.6–6.0] vs. LW 4.0 [2.8–5.1] and SRA 2.9 [1.7–4.1]). CONCLUSIONS: Interrupting prolonged sitting with brief bouts of LW or SRA attenuates acute postprandial glucose, insulin, C-peptide, and triglyceride responses in adults with T2D. With poor adherence to structured exercise, this approach is potentially beneficial and practical.
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“PA to break up sedentary behaviors can also have glycemic benefits.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [83]
In the citing paper
“Adults with T2DM had improvements in post-prandial sugars and triglyceride levels when interrupting prolonged sitting with 3minutes of light walking or simple resistance activities every 30 minutes.These values were measured as area under the curve over the 7-hour intervention, with a mean decrease in post-prandial sugars of 39%, insulin levels of around 36% in either activity group compared to”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [83]
In the citing paper
“Multiple studies have looked at brief interruptions of sedentary behavior with PA, and identified improvements in postprandial sugars, insulin levels, cholesterol, and weight circumference.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [83]
In the citing paper
“Low-intensity physical activity, 6 minutes hourly over an 8-hour period, in sedentary individuals lowered BP (14/8 mm Hg) and can improve metabolic syndrome variables.355–359”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [356]
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Metadata
- Authors
- Dempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., & Dunstan, D. W.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- Corresponding author
- Dempsey, Paddy C.
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2016-04-13
- Volume
- 39
- Issue
- 6
- Pages
- 964-972
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2337858743
- Cited by
- 405
- References
- 43
- Citations by year
- 2026: 28 · 2025: 28 · 2024: 37 · 2023: 44 · 2022: 51 · 2021: 48 · 2020: 45 · 2019: 35 · 2018: 37 · 2017: 39 · 2016: 12
- FWCI
- 33.02
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- National Health and Medical Research Council (1081734)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, prolonged sitting, sedentary behavior, postprandial blood glucose, insulin, C-peptide, triglycerides, cardiometabolic risk, glucose metabolism, overweight and obesity, physical activity breaks, calf raise, half squat
- MeSH terms
- Aged, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Insulin, Male, Middle Aged, Obesity, Posture, Triglycerides, Walking, Cross-Over Studies, Postprandial Period, Overweight, Resistance Training, Sedentary Behavior
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