Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

Luukkonen, Panu K.; Sädevirta, Sanja; Zhou, You; Kayser, Brandon; Ali, Ashfaq; Ahonen, Linda; Lallukka, Susanna; Pelloux, Véronique; Gaggini, Melania; Jian, Ching; Hakkarainen, Antti; Lundbom, Nina; Gylling, Helena; Salonen, Anne; Orešič, Matej; Hyötyläinen, Tuulia; Orho-Melander, Marju; Rissanen, Aila; Gastaldelli, Amalia; Clément, Karine; Hodson, Leanne; Yki-Järvinen, Hannele

doi:10.2337/dc18-0071

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

OBJECTIVE Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary…