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Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring
Open accessAbstract
While A1C is well established as an important risk marker for diabetes complications, with the increasing use of continuous glucose monitoring (CGM) to help facilitate safe and effective diabetes management, it is important to understand how CGM metrics, such as mean glucose, and A1C correlate. Estimated A1C (eA1C) is a measure converting the mean glucose from CGM or self-monitored blood glucose readings, using a formula derived from glucose readings from a population of individuals, into an estimate of a simultaneously measured laboratory A1C. Many patients and clinicians find the eA1C to be a helpful educational tool, but others are often confused or even frustrated if the eA1C and laboratory-measured A1C do not agree. In the U.S., the Food and Drug Administration determined that the nomenclature of eA1C needed to change. This led the authors to work toward a multipart solution to facilitate the retention of such a metric, which includes renaming the eA1C the glucose management indicator (GMI) and generating a new formula for converting CGM-derived mean glucose to GMI based on recent clinical trials using the most accurate CGM systems available. The final aspect of ensuring a smooth transition from the old eA1C to the new GMI is providing new CGM analyses and explanations to further understand how to interpret GMI and use it most effectively in clinical practice. This Perspective will address why a new name for eA1C was needed, why GMI was selected as the new name, how GMI is calculated, and how to understand and explain GMI if one chooses to use GMI as a tool in diabetes education or management.
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“The mean glucose of 154±26.8 mg/dL corresponded with an HbA1c of approximately 7%.14”
From Clinical utility of the twiist Automated Insulin Delivery System: first study with twiist (2026) · cites this paper as [14]
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“Using the standardized report the clinician can also address glucose variability (e.g., %CV metric) (75) or use glucose management indicator (GMI) metric (43) to discuss the possible discrepancies noted in glucose exposure derived from CGM data versus the individual's laboratory-measured A1C (40; 76).”
From Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range (2019) · cites this paper as [75]
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“For example, if HbA1c is lower than a concurrent GMI measure, the HbA1c can be interpreted to underestimate average blood glucose by the difference in measurements, allowing adjustment of HbA1c targets accordingly. 230,231”
From KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease (2022) · cites this paper as [230]
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International consensus on use of continuous glucose monitoring
Danne, T., Nimri, R., Battelino, T., Bergenstal, R. M., Close, K. L., DeVries, J. H., Garg, S., Heinemann, L., Hirsch, I., Amiel, S. A., et al. (2017) · Diabetes Care · doi:10.2337/dc17-1600 · Cited by 2,069 · cited 1×
“An international consensus group recently included the eA1C in its list of core CGMmetrics recommended for inclusion in all standard CGM reports (2).”
BackgroundSelf-citationTranslating the A1C assay into estimated average glucose values
Nathan, D. M., Kuenen, J., Borg, R., Zheng, H., Schoenfeld, D., Heine, R. J., & for the A1c-Derived Average Glucose (ADAG) Study Group (2008) · Diabetes Care · doi:10.2337/dc08-0545 · Cited by 1,812
Miller, K. M., Foster, N. C., Beck, R. W., Bergenstal, R. M., DuBose, S. N., DiMeglio, L. A., Maahs, D. M., & Tamborlane, W. V. (2015) · Diabetes Care · doi:10.2337/dc15-0078 · Cited by 1,254
Self-citationBeck, R. W., Riddlesworth, T., Ruedy, K., Ahmann, A., Bergenstal, R., Haller, S., Kollman, C., Kruger, D., McGill, J. B., Polonsky, W., et al. (2017) · JAMA · doi:10.1001/jama.2016.19975 · Cited by 1,185
Self-citationBeck, R. W., Riddlesworth, T. D., Ruedy, K., Ahmann, A., Haller, S., Kruger, D., McGill, J. B., Polonsky, W., Price, D., Aronoff, S., et al. (2017) · Annals of Internal Medicine · doi:10.7326/m16-2855 · Cited by 635
Self-citation4. Lifestyle Management: Standards of Medical Care in Diabetes—2018
American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc18-s004 · Cited by 563
Heinemann, L., Freckmann, G., Ehrmann, D., Faber-Heinemann, G., Guerra, S., Waldenmaier, D., & Hermanns, N. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30297-6 · Cited by 522 · cited 1×
“To validate this formula, CGM data from the HypoDE study (10) (141 individuals with T1D for whom 4 weeks of data were collected with the Dexcom G5 sensor prior to A1C measurement) were analyzed to compute the regression equation to estimate A1C from the CGMmeasured mean glucose concentration.”
MethodSelf-citationThe fallacy of average: how using HbA1c alone to assess glycemic control can be misleading
Beck, R. W., Connor, C. G., Mullen, D. M., Wesley, D. M., & Bergenstal, R. M. (2017) · Diabetes Care · doi:10.2337/dc17-0636 · Cited by 477
Self-citationAleppo, G., Ruedy, K. J., Riddlesworth, T. D., Kruger, D. F., Peters, A. L., Hirsch, I., Bergenstal, R. M., Toschi, E., Ahmann, A. J., Shah, V. N., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2482 · Cited by 329
Self-citationBergenstal, R. M., Ahmann, A. J., Bailey, T., Beck, R. W., Bissen, J., Buckingham, B., Deeb, L., Dolin, R. H., Garg, S. K., Goland, R., et al. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0051 · Cited by 307
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Items 101–200 of 615
Parr, E. B., Radford, B. E., Hall, R. C., Steventon-Lorenzen, N., Flint, S. A., Siviour, Z., Plessas, C., Halson, S. L., Brennan, L., Kouw, I. W. K., et al. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111893 · Cited by 43
“…glucose concentration between 0000 – 0600 h), nocturnal glucose concentration (i.e. average between 0000 – 0600 h), time in range (TIR; 3.9 – 10.0 mmol/L), time in tight range (TITR; 3.9 – 7.8 mmol/L), time above range (TAR; > 10 mmol/L), and glucose managment indicator (GMI) [29] were calculated.”
InfluentialFung, E., Lui, L.-T., Huang, L., Cheng, K. F., Lau, G. H. W., Chung, Y. T., Ahmadabadi, B. N., Xie, S., Lee, J. S. W., Hui, E., et al. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00251-8 · Cited by 36
Galindo, R. J., Parkin, C. G., Aleppo, G., Carlson, A. L., Kruger, D. F., Levy, C. J., Umpierrez, G. E., & McGill, J. B. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0107 · Cited by 38
Self-citationYost, O., DeJonckheere, M. J., Stonebraker, S., Ling, G., Buis, L. R., Pop‐Busui, R., Kim, N., Mizokami‐Stout, K., & Richardson, C. J. (2020) · JMIR Diabetes · doi:10.2196/21551 · Cited by 43
Diabetes Technology Use in Adults with Type 1 and Type 2 Diabetes
Kravarusic, J., & Aleppo, G. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.10.006 · Cited by 46
Self-citationDigital Health Interventions for Diabetes: Everything to Gain and Nothing to Lose
Kerr, D. E., King, F., & Klonoff, D. C. (2019) · Diabetes Spectrum · doi:10.2337/ds18-0085 · Cited by 39
“Glucose-based outcomes such as ambulatory glucose profiles (which show a patient’s daily glucose and insulin patterns, including time in the target range and a graphic representation of excursions out of that range) and glucose management indicators using CGM data are likely to have more impact for clinicians and peop…”
BackgroundEkberg, N. R., Hartvig, N. V., Kaas, A., Møller, J. B., & Adolfsson, P. (2024) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221104142 · Cited by 36
Vaibhav, V., Nishad, S., Dongare, D. B., Tripathi, A. C. P., Tripathi, T., & Tripathi, P. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100201 · Cited by 24
The Association of Time in Range and Diabetic Complications: The Evidence Is Strong
Beck, R. W. (2023) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0141 · Cited by 37
“8 It is presumed that the discordance is often due to red blood cell lifespan or other nonglycemic factors.”
Self-citationClinical application guidelines for blood glucose monitoring in China (2022 edition)
Bao, Y., Zhu, D., & Chinese Diabetes Society (2022) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3581 · Cited by 39
“From a clinical perspective, the potential discordance between GMI and HbA1c could help inform diabetes management.(74) For instance, a greater difference between HbA1c and GMI was associated with higher risk of hypoglycaemia in a non‐White population.”
BackgroundGarofolo, M., Aragona, M., Rodia, C., Falcetta, P., Bertolotto, A., Campi, F., Prato, S. D., & Penno, G. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.109066 · Cited by 33
“Estimated HbA1c (eA1c) and glucose management indicator (GMI) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .”
InfluentialCzupryniak, L., Dzida, G. J., Fichna, P., Jarosz-Chobot, P. A., Gumprecht, J., Klupa, T., Myśliwiec, M., Szadkowska, A., Bomba-Opon, D. A., Czajkowski, K., et al. (2022) · Diabetes Therapy · doi:10.1007/s13300-022-01229-9 · Cited by 35
“02392 9 mean glucose concentration (mg/dL) [14]”
Non-invasive wearables for remote monitoring of HbA1c and glucose variability: proof of concept
Bent, B., Cho, P. J., Wittmann, A., Thacker, C., Muppidi, S., Snyder, M. P., Crowley, M. J., Feinglos, M. N., & Dunn, J. (2021) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-002027 · Cited by 43
Arunachalum, S., Velado, K., Vigersky, R. A., & Cordero, T. L. (2022) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221088608 · Cited by 35
Efficacy of telemedicine for persons with type 1 diabetes during Covid19 lockdown
Boscari, F., Ferretto, S., Uliana, A., Avogaro, A., & Bruttomesso, D. (2021) · Nutrition & Diabetes · doi:10.1038/s41387-020-00147-8 · Cited by 31
Low carbohydrate high fat ketogenic diets on the exercise crossover point and glucose homeostasis
Noakes, T. D., Prins, P., Volek, J. S., D’Agostino, D. P., & Koutnik, A. P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150265 · Cited by 39
“Importantly, these glycemic phenotypes were captured utilizing 24-hour, minute-by-minute continuous glucose monitoring as it tracks long-term to HbA1c (Bergenstal et al., 2018; Hirsch et al., 2019; Valenzano et al., 2021), short term continuous glucose monitoring readings (10–14 days) are good estimates of 3-month con…”
BackgroundInfluentialDiscordance Between Glucose Management Indicator and Glycated Hemoglobin in People Without Diabetes
Shah, V. N., Vigers, T., Pyle, L. L., Calhoun, P. M., & Bergenstal, R. M. (2023) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2022.0544 · Cited by 34
Self-citationPrins, P., Noakes, T. D., Buga, A., D’Agostino, D. P., Volek, J. S., Buxton, J. D., Heckman, K., Jones, D. W., Tobias, N. E., Grose, H. M., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1084021 · Cited by 44
Intralymphatic GAD-Alum (Diamyd®) Improves Glycemic Control in Type 1 Diabetes With HLA DR3-DQ2
Nowak, C., Lind, M., Šumník, Z., Pelikánová, T., Nattero‐Chávez, L., Lundberg, E., Rica, I., Martínez‐Brocca, M. A., de Adana, M. R., Wahlberg, J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac343 · Cited by 33
“02392 × [mean glucose in mg/dL], and expressed as % DCCT units, similar to HbA1c) (22).”
Benhamou, P., Lablanche, S., Vambergue, A., Doron, M., Franc, S., & Charpentier, G. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14214 · Cited by 39
Kumbara, A. B., Iyer, A. K., Green, C. R., Jepson, L. H., Leone, K., Layne, J. E., & Shomali, M. (2023) · JMIR Diabetes · doi:10.2196/47638 · Cited by 29
Lameijer, A., Lommerde, N., Dunn, T. C., Fokkert, M. J., Edens, M. A., Kao, K., Xu, Y., Gans, R. O. B., Bilo, H. J. G., & van Dijk, P. R. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108897 · Cited by 27
PAULEY, M. E., Tommerdahl, K. L., Snell‐Bergeon, J. K., & Forlenza, G. P. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01799-x · Cited by 39
The automated pancreas: A review of technologies and clinical practice
Biester, T., Tauschmann, M., Chobot, A. P., Kordonouri, O., Danne, T., Kapellen, T. M., & Dovč, K. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14576 · Cited by 32
“A glucose management index can be derived from the accumulated data, which is close to the measured HbA1c value.(9) F IGURE 7 Open-source automated insulin delivery (AID) system in use, with continuously high values, in which presets were changed several times (blue letters) without success; no ketone measurement or c…”
MethodFreckmann, G., Pleus, S., Schauer, S., Link, M., Jendrike, N. R. M., Waldenmaier, D., Haug, C., & Stuhr, A. (2021) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1347-2550 · Cited by 30
Continuous Glucose Monitoring–Derived Data Report—Simply a Better Management Tool
Battelino, T., & Bergenstal, R. M. (2020) · Diabetes Care · doi:10.2337/dci20-0032 · Cited by 27
Self-citationSoftware Packages and Tools for the Analysis of Continuous Glucose Monitoring Data
Piersanti, A., Giurato, F., Göbl, C. S., Burattini, L., Tura, A., & Morettini, M. (2022) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2022.0237 · Cited by 31
“…percentage of time in target range (%TIR), percentage of time in hyperglycemic ranges (%TAR level 1 and 2), the glucose management indicator (GMI 41 ), reports on data sufficiency (percentage of expected CGM readings), area under the glycemic curve (AUC) divided by the time in hours, risk of…”
Use of Glucose-Lowering Agents in Diabetes and CKD
Alicic, R. Z., Neumiller, J. J., Galindo, R. J., & Tuttle, K. R. (2022) · Kidney International Reports · doi:10.1016/j.ekir.2022.09.018 · Cited by 35
“” Glucose management indicator is a metric to estimate HbA1c, as derived from CGM values, that can be reported to patients as an alternative to HbA1c.(71) For most patients, target time in range (time-in-target range 70 180 mg/dl or 3.”
BackgroundInfluentialLeveraging advances in diabetes technologies in primary care: a narrative review
Bode, B. W., King, A., Russell-Jones, D. L., & Billings, L. K. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1931427 · Cited by 41
Samson, S. L., Vellanki, P., Blonde, L., Hirsch, I. B., Hoang, T. D., Isaacs, S. D., Izuora, K. E., Wang, C. C. L., Ooi, C. P., Padilla, B. I., et al. (2026) · Endocrine Practice · doi:10.1016/j.eprac.2026.01.006 · Cited by 29
Pleus, S., Kamecke, U., Waldenmaier, D., Link, M., Zschornack, E., Jendrike, N. R. M., Haug, C., & Freckmann, G. (2020) · Journal of Diabetes Science and Technology · doi:10.1177/1932296820931825 · Cited by 34
“1106 Journal of Diabetes Science and Technology 15(5)”
BackgroundInfluentialCarlson, A. L., Criego, A. B., Martens, T. W., & Bergenstal, R. M. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.10.010 · Cited by 33
Self-citationAktürk, H. K., Battelino, T., Castañeda, J., Arrieta, A., van den Heuvel, T. R. A., & Cohen, O. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0432 · Cited by 26
“18,24 TIR was also suggested as a primary endpoint in diabetes clinical trials by the International Consensus.”
Leelarathna, L., Beck, R. W., Bergenstal, R. M., Thabit, H., & Hovorka, R. (2019) · Diabetes Care · doi:10.2337/dc18-2479 · Cited by 28
“The glucose management indicator (GMI) is an updated approach for estimating HbA1c from continuous glucose monitoring (CGM) data (1).”
BackgroundMethodInfluentialSelf-citationBrown, S. A., Basu, A., & Kovatchev, B. P. (2019) · Diabetic Medicine · doi:10.1111/dme.13944 · Cited by 27
Perioperative Care of Patients Using Wearable Diabetes Devices
Cruz, P., McKee, A. M., Chiang, H.-H., McGill, J. B., Hirsch, I. B., Ringenberg, K. J., & Wildes, T. S. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007115 · Cited by 32
Oriot, P., Viry, C., Vandelaer, A., Grigioni, S., Roy, M., Philips, J., & Prévost, G. (2022) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221092050 · Cited by 26
“10 Some studies reported discordances between lab HbA 1 c and GMI, but data are still limited in individuals with diabetes and CKD. 10,11 The purpose of this study is to compare the relationship between HbA 1 c measured in the laboratory and GMI calculated from 14 and 90 days CGM data recorded in a…”
MethodInfluentialNot Control but Conquest: Strategies for the Remission of Type 2 Diabetes Mellitus
Kim, J., & Kwon, H. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0377 · Cited by 31
“Since continuous glucose monitoring (CGM) has been recently applied, it is recommended to use the estimated HbA1c level (eA1c) or a glucose management indicator on CGM [22].”
MethodBlood Glucose Monitoring in Adults and Children with Diabetes: Update 2021
CHENG, A. Y. Y., Feig, D. S., Ho, J., Siemens, R. L., BAJAJ, H. S., Gilbert, J. D., Houlden, R. L., Kim, J., MacKay, D., Rabi, D. M., et al. (2021) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2021.07.003 · Cited by 36
Practical guidance for using the FreeStyle Libre flash continuous glucose monitoring in primary care
Unger, J., Kushner, P. R., & Anderson, J. E. (2020) · Postgraduate Medicine · doi:10.1080/00325481.2020.1744393 · Cited by 27
“The report also presents the average glucose and the glucose management indicator (GMI) statistic, which closely aligns with HbA1c levels [48].”
BackgroundChinese clinical guidelines for continuous glucose monitoring (2018 edition)
Bao, Y., Chen, L., Chen, L., Dou, J., Gao, Z., Gao, L., Guo, L., Guo, X., Ji, L., Ji, Q., et al. (2019) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3152 · Cited by 23
“Many patients and clinicians find the GMI to be a helpful educational tool in understanding the CGM‐ generated glucose profiles and will facilitate optimal diabetes management and the adjustment of anti‐diabetic therapy.(113)”
BackgroundCandidate Selection for Hybrid Closed Loop Systems
Forlenza, G. P., Breton, M. D., & Kovatchev, B. P. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0217 · Cited by 20
Crossen, S. S., Romero, C. C., Lewis, C., & Glaser, N. S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1063290 · Cited by 22
Continuous glucose sensor accuracy: beyond the headline metric
Oliver, N. S., Reddy, M., & Leelarathna, L. (2024) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00245-6 · Cited by 20
An automatic deep reinforcement learning bolus calculator for automated insulin delivery systems
Ahmad, S., Beneyto, A., Zhu, T., Contreras, I., Georgiou, P., & Vehí, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-62912-4 · Cited by 25
“The GMI, an approximation of the A1C level based on the average BG from CGM 50 , was similar in all cases.”
MethodContinuous Glucose Monitoring in Dogs and Cats
Baldo, F. D., & Fracassi, F. (2023) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2023.01.008 · Cited by 20
AGATA: A Toolbox for Automated Glucose Data Analysis
Cappon, G., Sparacino, G., & Facchinetti, A. (2023) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221147570 · Cited by 22
Piccini, B., Pessina, B., Casalini, E., Lenzi, L., & Toni, S. (2022) · Pediatric Diabetes · doi:10.1111/pedi.13440 · Cited by 22
Smith, K., Taylor, G., Brunsgaard, L. H., Walker, M., Davies, K. A. B., Stevenson, E., & West, D. J. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-002820 · Cited by 23
Carlson, A. L., Martens, T. W., Johnson, L., & Criego, A. B. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0241 · Cited by 28
“18 The panel also endorsed use of the Ambulatory Glucose Profile (AGP) as a template for presenting CGM data in a standardized report.”
Díaz-Soto, G., Bahillo-Curieses, P., Jimenez, R., de la Marca, M. D. L. O. N., Hoyos, E. G., Torres, B., Gómez, J. J. L., & de Luis, D. A. (2021) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.09.008 · Cited by 13
Rachmiel, M., Lebenthal, Y., Mazor‐Aronovitch, K., Brener, A., Levek, N., Levran, N., Chorna, E., Dekel, M., Barash, G., Landau, Z., et al. (2021) · Acta Diabetologica · doi:10.1007/s00592-021-01673-2 · Cited by 26
“ADHD Attention-deficit hyperactivity disorder CGM Continuous glucose monitoring GMI Glycaemic metabolic index TIR Time in range”
InfluentialRegelmann, M. O., Conroy, R., Gourgari, E., Gupta, A., Guttmann‐Bauman, I., Heksch, R. A., Kamboj, M. K., Krishnan, S., Lahoti, A., & Matlock, K. A. (2020) · Hormone Research in Paediatrics · doi:10.1159/000513060 · Cited by 26
Critical Reappraisal of the Time-in-Range: Alternative or Useful Addition to Glycated Hemoglobin?
Heinemann, L., Freckmann, G., Müller‐Wieland, D., & Kellerer, M. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819883885 · Cited by 25
“We will not discuss any different approaches to calculate an HbA1c value from the measured (blood) glucose values (estimated HbA1c or eHbA1c); as per the FDA, the term “Glucose Management Indicator” is now used for this purpose.(1,2) Likewise, we will not discuss the “estimated average glucose (eAG)”, where—contrary t…”
MethodSelf-citationGrimsmann, J. M., von Sengbusch, S., Freff, M., Ermer, U., Placzek, K., Danne, T., Hammer, E., & Holl, R. (2020) · Diabetes Care · doi:10.2337/dc20-0259 · Cited by 22
“The formula was developed with real-time CGM (rtCGM) sensors (1).”
BackgroundMethodInfluentialDril, E. V., & Schumacher, C. (2019) · JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · doi:10.1002/jac5.1088 · Cited by 25
Beyond A1C: exploring continuous glucose monitoring metrics in managing diabetes
Friedman, J. G., Coyne, K., Aleppo, G., & Szmuilowicz, E. D. (2023) · Endocrine Connections · doi:10.1530/ec-23-0085 · Cited by 22
Self-citationTime in range—A new gold standard in type 2 diabetes research?
Goshrani, A., Lin, R., O'Neal, D. N., & Ekinci, E. I. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16279 · Cited by 25
Diabetes technology in people with diabetes and advanced chronic kidney disease
Galindo, R. J., Soliman, D., Cherñavvsky, D. R., & Rhee, C. M. (2024) · Diabetologia · doi:10.1007/s00125-024-06244-y · Cited by 21
Estimating Glycemia From HbA1c and CGM: Analysis of Accuracy and Sources of Discrepancy
Tozzo, V., Genco, M. T., Omololu, S. O., Mow, C., Patel, H. R., Patel, C. H., Ho, S. N., Lam, E., Abdulsater, B., Patel, N., et al. (2024) · Diabetes Care · doi:10.2337/dc23-1177 · Cited by 28
Roxburgh, B. H., Campbell, H. A., Cotter, J. D., Reymann, U., Williams, M. J. A., Gwynne‐Jones, D., & Thomas, K. N. (2023) · Physiological Reports · doi:10.14814/phy2.15699 · Cited by 22
“Glucose management indicator is a novel measure for estimating A1c from CGM devices (Bergenstal et al., 2018); this was calculated as 12.71 + 4.70587 × [mean glucose in mmol L−1].”
MethodInfluentialXu, Y., Bergenstal, R. M., Dunn, T. C., Ram, Y., & Ajjan, R. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14763 · Cited by 23
“Results: The mean age (range) was 30 years (8-72) with 94 younger than 19 years,”
BackgroundSelf-citationShahid, A., & Lewis, D. (2022) · Nutrients · doi:10.3390/nu14091906 · Cited by 21
“Glycemic management indicator GMI Indicates the expected mean hemoglobin A1C using mean glucose of individuals with diabetes [36].”
MethodPiona, C., Marigliano, M., Mozzillo, E., Candia, F. D., Zanfardino, A., Iafusco, D., Maltoni, G., Zucchini, S., Piccinno, E., & Maffeis, C. (2021) · Pediatric Diabetes · doi:10.1111/pedi.13299 · Cited by 21
“This metric is calculated from the mean glucose value using an equation derived from HbA1c and CGM data of four clinical trials.(2) These trials included subjects using Dexcom G4 and G5 sensors with a wide range of age and affected by both type 1 and type 2 diabetes.”
MethodMarks, B. E., Williams, K. M., Sherwood, J. S., & Putman, M. S. (2021) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2021.100282 · Cited by 30
“3 which provides an estimate of the A1c when ≥ 10 days of glucose data are available [28,29].”
BackgroundKim, J. H. (2020) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2040038.019 · Cited by 22
Kahkoska, A. R., Adair, L. S., Aiello, A. E., Burger, K. S., Buse, J. B., Crandell, J., Maahs, D. M., Nguyen, C. T., Kosorok, M. R., & Mayer‐Davis, E. J. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12856 · Cited by 20
“Recently, CGM data have also been used to provide validated metrics such as time in range(5,6) or average glucose exposure over a shorter period of time, also referred to as the glucose management indicator.(7) CGM as a source of patient data thus offers the opportunity to understand patterns of glycemia that are not…”
MethodPöhlmann, J., Smith‐Palmer, J., Serné, E. H., Tuomaala, A., JENDLE, J. H., Choudhary, P., Bosi, E., Mohan, V., van den Heuvel, T. R. A., Cohen, O., et al. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70161 · Cited by 21
“37,50 In addition, the percentage of users achieving glycaemic targets such as TIR >70% or HbA1c 7% was an eligible outcome.”
Is It Time to Replace Time-in-Range with Time-in-Tight-Range? Maybe Not
Beck, R. W. (2023) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0602 · Cited by 20
Self-citationAssessment of the Glucose Management Indicator Using Different Sampling Durations
Bailey, R. J., Calhoun, P. M., Bergenstal, R. M., & Beck, R. W. (2022) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2022.0284 · Cited by 22
Self-citationGouveri, E., & Παπάνας, Ν. (2022) · Diabetes Therapy · doi:10.1007/s13300-022-01257-5 · Cited by 22
“The use of CGM systems has been associated with increased TIR and reduced incidence of severe episodes of hypoglycaemia [16].”
BackgroundUtilizing continuous glucose monitoring in primary care practice: What the numbers mean
Edelman, S. V., Cavaiola, T. S., BOEDER, S. C., & Pettus, J. (2020) · Primary care diabetes · doi:10.1016/j.pcd.2020.10.013 · Cited by 25
Piona, C. A., Marigliano, M., Mozzillo, E., Franzese, A., Zanfardino, A., Iafusco, D., Maltoni, G., Zucchini, S., Delvecchio, M., & Maffeis, C. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13115 · Cited by 21
Aleppo, G., DeSalvo, D. J., Lauand, F., Huyett, L. M., Chang, A., Vienneau, T., & Ly, T. T. (2023) · Diabetes Therapy · doi:10.1007/s13300-023-01366-9 · Cited by 19
Self-citation“Hyperglycemia aversiveness”: investigating an overlooked problem among adults with type 1 diabetes
Polonsky, W. H., Fortmann, A. L., Price, D., & Fisher, L. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2021.107925 · Cited by 19
Basiri, R., & Cheskin, L. J. (2024) · Nutrients · doi:10.3390/nu16234005 · Cited by 22
“A significant reduction in GMI was observed in the treatment group but not in the control group, which potentially suggests a decrease in HbA1c and future diabetes-related complications [32,53].”
Weinstock, R. S., Raghinaru, D., Gal, R. L., Bergenstal, R. M., Bradshaw, A., Cushman, T., Kollman, C., Kruger, D. F., Johnson, M. L., MCARTHUR, T. S., et al. (2024) · Journal of Diabetes Science and Technology · doi:10.1177/19322968241294250 · Cited by 18
Self-citationMulti-Horizon Glucose Prediction Across Populations With Deep Domain Generalization
Zhu, T., Afentakis, I., Li, K., Armiger, R., Hill, N. E., Oliver, N. S., & Georgiou, P. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3428921 · Cited by 21
“…CGM metrics that have been recognized by international consensus for their applications in clinical diabetes care [7], which include glucose management indicator (GMI) [57], time below range (TBR), time in range (TIR), time above range (TAR), blood glucose index, and coefficient of variation (CV).”
Wang, Y., Lu, J., Shen, Y., Ni, J., Zhang, L., Lu, W., Zhu, W., Bao, Y., & Zhou, J. (2022) · Journal of Diabetes Investigation · doi:10.1111/jdi.13811 · Cited by 23
Ling, J., Ng, J. K., Lau, E. S. H., Ronald, C. W., Kong, A. P. S., Luk, A. O. Y., Kwok, J. S.-S., Szeto, C., Chan, J. C. N., & Chow, E. (2022) · Kidney International Reports · doi:10.1016/j.ekir.2022.03.029 · Cited by 18
“uACR (mg/mmol) 100 (28-305) 26 (5-105) 163 (41-271) 353 (125-423) 0.”
A New Analysis Tool for Continuous Glucose Monitor Data
OLAWSKY, E. A., Zhang, Y., Eberly, L. E., Helgeson, E. S., & Chow, L. S. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211028909 · Cited by 19
Chung, S. M., Lee, Y. H., Kim, C. O., Lee, J. Y., Jin, S., Yoo, S.-H., Moon, J. S., & Kim, K. J. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e190 · Cited by 23
Wafa, I. A., Pratama, N. R., Sofia, N. F., Anastasia, E. S., Konstantin, T., Wijaya, M. A., Wiyono, M. R., Djuari, L., & Novida, H. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0125 · Cited by 24
Quality of Glycemic Control: Assessment Using Relationships Between Metrics for Safety and Efficacy
Rodbard, D. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0115 · Cited by 21
Domínguez, Ó. M., de Villar, N. G. P., Barquiel, B., Hillman, N., Gaspar, R., Arévalo-Gómez, M., & Herranz, L. (2020) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2020.0550 · Cited by 20
Kriventsov, S., Lindsey, A., & Hayeri, A. (2020) · JMIR Diabetes · doi:10.2196/18660 · Cited by 22
A systematic review on clinical implication of continuous glucose monitoring in diabetes management
Gillani, S. W., Azhar, A., Mohiuddin, G., & Majeed, R. A. (2020) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_7_20 · Cited by 29
Leong, A., Lim, V., Wang, C., Chai, J. F., Dorajoo, R., Heng, C., van Dam, R. M., Koh, W., Yuan, J., Jonas, J. B., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-001091 · Cited by 19
“31 32 Nevertheless, continuous glucose monitoring is not routinely used to detect pre-diabetes or diabetes, and so comparing the diagnostic classification by HbA1c to FG is more aligned with current screening practices.”
Liu, H., Yang, D., Deng, H., Xu, W., Lv, J., Zhou, Y., Luo, S., Zheng, X., Liang, H., Yao, B., et al. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820931664 · Cited by 22
Reducing Diabetes Burden in Medtronic's Automated Insulin Delivery Systems
Forlenza, G. P., Dai, Z., Niu, F., & Shin, J. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2023.0459 · Cited by 20
Elbarbary, N. S., & Ismail, E. A. R. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01184-w · Cited by 20
“As described in several publications, only patients with ≥ 14 days of SG data were used to determine CGM-derived metrics [6, 23, 24].”
MethodParise, M., Tartaglione, L., Cutruzzolà, A., Maiorino, M. I., Esposito, K., Pitocco, D., Gnasso, A., & Irace, C. (2021) · Journal of Medical Internet Research · doi:10.2196/24552 · Cited by 25
“The coefficient of variation (CV)—an estimate of glycemic variability—and the GMI—an estimate of glycated hemoglobin levels—were determined using the following formulae if not automatically generated by the software analyzing glucose data [12]:”
Bergenstal, R. M. (2023) · Diabetes Spectrum · doi:10.2337/dsi23-0005 · Cited by 19
Self-citationPatient Perspectives on the Benefits and Challenges of Diabetes and Digital Technology
Edelman, S. V., Cheatham, W. W., Norton, A., & Close, K. L. (2023) · Clinical Diabetes · doi:10.2337/cd23-0003 · Cited by 18
“GMI is an estimate of A1C based on the average of glucose data collected by the device sensor during the report period and may differ from the laboratory-measured A1C (24,38).”
MethodSelf-citationPerformance of the Glucose Management Indicator (GMI) in Type 2 Diabetes
Fang, M., Wang, D., Rooney, M. R., Echouffo-Tcheugui, J. B., Coresh, J., Aurora, R. N., Punjabi, N. M., & Selvin, E. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvac210 · Cited by 22
Munda, A., Kovacic, C., & Barlovič, D. P. (2022) · Metabolites · doi:10.3390/metabo12111137 · Cited by 17
Freckmann, G., Schauer, S., Beltzer, A., Waldenmaier, D., Buck, S., Baumstark, A., Jendrike, N. R. M., Link, M., Zschornack, E., Haug, C., et al. (2022) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221113341 · Cited by 23
Shah, V. N., Snell‐Bergeon, J. K., Demmitt, J. K., Joshee, P., Garcetti, R., Pyle, L. L., & Polsky, S. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0093 · Cited by 25
“12,13 The GMI was developed and validated from CGM data of randomized controlled clinical trials that excluded pregnant women with diabetes.”
van der Linden, J. H., Welsh, J., Hirsch, I., & Garg, S. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2020.0649 · Cited by 17
“The glucose management indicator (GMI) is a linear function of mean glucose values as previously described.(14) The dependent t-test for paired samples was used for prepandemic and intrapandemic TIR comparisons; the simple linear Pearson correlation coefficient was used to test the relationship between regional diseas…”
MethodXu, Y., Grimsmann, J. M., Karges, B., Hofer, S. E., Danne, T., Holl, R. W., Ajjan, R., & Dunn, T. C. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2020.0553 · Cited by 19
“The most widely adopted methods are estimated HbA1c (eHbA1c) 3 and glucose management indicator (GMI), 4 which assume a universal linear correlation between glucose and HbA1c.”
Metadata
- Authors
- Bergenstal, R. M., Beck, R. W., Close, K. L., Grunberger, G., Sacks, D. B., Kowalski, A., Brown, A. S., Heinemann, L., Aleppo, G., Ryan, D. B., Riddlesworth, T. D., & Cefalu, W. T.
- Affiliations
- Park Nicollet Health Services (US)
- Jaeb Center for Health Research (US)
- The diaTribe Foundation, San Francisco, CA
- Grunberger Diabetes Institute (US)
- National Institutes of Health (US)
- Breakthrough T1D (US)
- Close Concerns (United States) (US)
- Science Consulting in Diabetes, Neuss, Germany
- Northwestern University (US)
- Sacred Heart Hospital (US)
- American Diabetes Association (US)
- Corresponding author
- Bergenstal, Richard M.
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2018-09-17
- Volume
- 41
- Issue
- 11
- Pages
- 2275-2280
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC6196826
- OpenAlex
- W2891178783
- Cited by
- 684
- References
- 18
- Citations by year
- 2026: 79 · 2025: 95 · 2024: 114 · 2023: 84 · 2022: 95 · 2021: 101 · 2020: 75 · 2019: 34 · 2018: 6
- FWCI
- 43.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK108611)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucose management indicator, continuous glucose monitoring, HbA1c, mean blood glucose, nomenclatural changes, diabetes management, diabetes education
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Health Education, Health Status Indicators, Glycated Hemoglobin, Humans, Terminology as Topic, Statistics as Topic, Blood Glucose Self-Monitoring
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