Transitioning of people with type 1 diabetes from multiple daily injections and self-monitoring of blood glucose directly to MiniMed 780G advanced hybrid closed-loop system: a two-center, randomized, controlled study
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Abstract
OBJECTIVE: The aim of this study was to evaluate the outcomes of transitioning to the MiniMed 780G advanced hybrid closed-loop (AHCL) system in adult individuals with type 1 diabetes mellitus (T1DM) naive to continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) technologies. RESEARCH DESIGN AND METHODS: This was a two-center, randomized, controlled, parallel-group trial with evaluation of individuals with T1DM aged 26-60 years managed with multiple daily injections (MDI) and self-monitoring of blood glucose (BGM) with HbA1c <10%. RESULTS: A total of 41 participants were recruited and randomized to either the AHCL (n = 20) or the MDI+BGM (n = 21) group, and 37 participants (mean ± SD age 40.3 ± 8.0 years, duration of diabetes 17.3 ± 12.1 years, BMI 25.1 ± 3.1 kg/m2, HbA1c 7.2 ± 1.0%) completed the study. Time spent with glucose levels in target range increased from 69.3 ± 12.3% at baseline to 85.0 ± 6.3% at 3 months in the AHCL group, while remaining unchanged in the control group (treatment effect 21.5% [95% CI 15.7, 27.3]; P < 0.001). The time with levels below range (<70 mg/dL) decreased from 8.7 ± 7.3% to 2.1 ± 1.7% in the AHCL group and remained unchanged in the MDI+BGM group (treatment effect -4.4% [95% CI -7.4, -2.1]; P < 0.001). Participants from the AHCL group also had significant improvements in HbA1c levels (treatment effect -0.6% [95% CI -0.9, -0.2]; P = 0.005) and in quality of life (QoL) in specific subscales compared with the MDI+BGM group. CONCLUSIONS: People with T1DM naive to CSII and CGM technologies initiating AHCL significantly and safely improved their glycemic control, as well as their QoL and psychological well-being.
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Studies evaluating closed-loop systems (Choudhary et al., 2022; Matejko et al., 2022) reported significant improvements in quality of life measures.
“the studies evaluating closed-loop systems (Choudhary et al., 2022, Matejko et al., 2022) reported significant improvements in quality of life measures.”
From Effectiveness of continuous glucose monitoring systems on glycemic control in adults with type 1 diabetes: A systematic review and meta-analysis (2025) · cites this paper as Matejko et al., 2022
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- Authors
- Matejko, B., Juza, A., Kieć-Wilk, B., Cyranka, K., Krzyżowska, S., Chen, X., Cohen, O., Da Silva, J., Malecki, M. T., & Klupa, T.
- Affiliations
- Jagiellonian University (PL)
- University of Rzeszów (PL)
- 1Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
- Szpital Uniwersytecki w Krakowie (PL)
- 6Medtronic, Northridge, CA
- Medtronic (Switzerland) (CH)
- 7Medtronic International Trading Sàrl, Tolochenaz, Switzerland
- Corresponding author
- Klupa, Tomasz
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2022-08-15
- Volume
- 45
- Issue
- 11
- Pages
- 2628-2635
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC9862281
- OpenAlex
- W4291972723
- Cited by
- 72
- References
- 30
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 19 · 2023: 26 · 2022: 3
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Care (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Funders
- Medtronic (ERP-2019-12000)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 1 diabetes, MiniMed 780G, advanced hybrid closed-loop system, insulin pump therapy, continuous glucose monitoring, self-monitoring of blood glucose, glycemic control, HbA1c, time in range, hypoglycemia, quality of life, adults with type 1 diabetes, diabetes technology adoption
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Injections, Subcutaneous, Insulin, Insulin Infusion Systems, Quality of Life, Blood Glucose Self-Monitoring
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