Objective and subjective sleep patterns in adults with maturity-onset diabetes of the young (MODY)
Open accessAbstract
OBJECTIVE: To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY). RESEARCH DESIGN AND METHODS: Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys. RESULTS: Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns. CONCLUSIONS: Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.
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In an earlier study of 24 adults, OSA was highly prevalent (58%) in those with MODY.
“In an earlier study of 24 adults, we also reported that OSA was highly prevalent (58%) in those with MODY (11).”
From Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young (2026) · cites this paper as [11]
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Arosemena, M., Chopra, K., Salguero, M. V., Reyes, D., Naylor, R. N., Wroblewski, K., Tasali, E., & Philipson, L. H. (2026) · Diabetes · doi:10.2337/db24-0787 · Cited by 2 · see citing works
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- Authors
- Arosemena, M., Salguero, M. V., Naylor, R. N., Wroblewski, K., Tasali, E., & Philipson, L. H.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Arosemena, Marilyn
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2023-01-13
- Volume
- 46
- Issue
- 3
- Pages
- 608-612
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- PMC
- PMC10090264
- OpenAlex
- W4315928390
- Cited by
- 4
- References
- 22
- Citations by year
- 2025: 4
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Diabetes Care (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association (7-22-ICTSPM-17)
- University of Chicago
- National Institutes of Health (P30DK02059)
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences (T32GM007196, T32GM007019)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK120312, R01DK104942, P30DK020593, U54DK118612, P30DK020595)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Keywords
- maturity-onset diabetes of the young, monogenic diabetes, sleep patterns, sleep quality, obstructive sleep apnea, insomnia, sleep duration, HNF1A, HNF1B, HNF4α, actigraphy, home sleep apnea testing
- MeSH terms
- Diabetes Mellitus, Type 2, Female, Glucokinase, Humans, Male, Middle Aged, Mutation, Risk Factors, Sleep, Sleep Disorders, Intrinsic, Hepatocyte Nuclear Factor 1-alpha
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