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Cited by 245

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Light and Electron Microscopy of Lesions in Rats Rendered Diabetic with Streptozotocin

Arison, R N, Ciaccio, E I, Glitzer, M S, Cassaro, J A, Pruss, M P·1967·Diabetes
DOI 10.2337/diab.16.1.51
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Abstract

Light and electron microscopic examination of organs of rats rendered hyperglycemic with streptozotocin revealed the following: (1) rapid degranulation of beta cells without necrosis; (2) development of cataracts in four months after injection of 65 mg. per kilogram of the drug; (3) accumulation of glycogen in the proximal convoluted tubules of the kidney after 65 mg. per kilogram; (4) lesions in the exocrine cells of the pancreas after 100 mg. per kilogram; and (5) persistence of small, possibly secretory, granules in the Golgi zone of beta cells in diabetic rats. The significance of these findings is discussed.

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Metadata

Authors
Arison, R. N., Ciaccio, E. I., Glitzer, M. S., Cassaro, J. A., & Pruss, M. P.
Venue
Diabetes
Publisher
American Diabetes Association
Published
1967-01-01
Volume
16
Issue
1
Pages
51-56
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.16.1.51
OpenAlex
W2132398039
Cited by
245
References
0
FWCI
22.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Light and Electron Microscopy of Lesions in Rats Rendered Diabetic with Streptozotocin. https://app.cochat.ai/papers/10.2337/diab.16.1.51
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Arison, R. N., Ciaccio, E. I., Glitzer, M. S., Cassaro, J. A., & Pruss, M. P. (1967). Light and Electron Microscopy of Lesions in Rats Rendered Diabetic with Streptozotocin. Diabetes. https://doi.org/10.2337/diab.16.1.51

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.