Metabolic clearance of insulin in man
Abstract
Metabolic clearance of insulin was measured, under circumstances of acutely and chronically altered endogenous plasma insulin, employing 1-131 bovine insulin (5 mc./mg., Abbott Laboratories) as tracer and the technic of constant infusion to equilibrium. Compared to normal subjects, clearance of radioiodinated insulin was unaffected by diabetes, was increased 25 per cent in obese subjects with hyperinsulinemia and did not change when their plasma insulin was reduced by seven days of fasting. Acute fourto fifteenfold elevation of endogenous insulin by glucose or tolbutamide injections to normal and obese subjects also failed to change clearance of radioiodinated insulin. These data support the assumption that alterations of plasma insulin in those circumstances largely reflect alterations in insulin secretion. However, in both normal and diabetic subjects, simultaneous clearances of unlabeled porcine insulin and radioiodinated insulin were also performed and disparate results obtained. Mean values were: unlabeled 861 ml./min. (Normals), 788 ml./min. (Diabetics) ; radioiodinated 227 ml./min. (Normals) ; 202 ml./min. (Diabetics). Ratio of unlabeled to radioiodinated clearance 3.8 (Normals), 4.1 (Diabetics). Because of this discrepancy, it is uncertain which clearance value affords the more accurate estimate of peripheral insulin delivery rate.
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In small groups of diabetic patients, insulin clearance has been reported to be normal, decreased, or even increased.
“In small groups of diabetic patients, insulin clearance has reported to be normal, 16 -18 decreased, 19,20 or even increased.21”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [18]
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by Plasma In Vitro and In Vivo to a Biologically Inactive Product Cleaved at the NH2 Terminus
Frohman, L. A., Downs, T. R., Williams, T. C., et al. (1986)
Kotronen, A., Juurinen, L., Tiikkainen, M., & Vehkavaara, S. (2008)
- Authors
- Genuth, S. M.
- Affiliations
- Mount Sinai Hospital (US)
- Corresponding author
- Genuth, Saul M
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1972-10-01
- Volume
- 21
- Issue
- 10
- Pages
- 1003-1012
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2120227540
- Cited by
- 72
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2016: 1
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin clearance, metabolic clearance, insulin secretion, diabetes mellitus, obesity, hyperinsulinemia, fasting, glucose stimulation, tolbutamide
- MeSH terms
- Adolescent, Adult, Aged, Animals, Body Surface Area, Body Weight, Cattle, Diabetes Mellitus, Fasting, Female, Glucose, Glucose Tolerance Test, Humans, Hyperinsulinism, Hyperthyroidism, Insulin, Iodine Radioisotopes, Islets of Langerhans, Male, Metabolic Clearance Rate, Middle Aged, Obesity, Swine, Tolbutamide
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