Kinetics of glucagon in man: effects of starvation.
Open accessAbstract
Serum stimulates the production of prostaglandins by transformed mouse fibroblasts. Hydrocortisone (cortisol) inhibits this stimulation. The half-maximal inhibition occurs at 6x10-9 M. Studies with cells labeled with [3H]arachidonic acid in their lipids show that the stimulation by serum results in the release of arachidonic acid from the cellular lipids, mostly phospholipids. Hydrocortisone inhibits this release but does not inhibit the production of prostaglandins from exogenously supplied arachidonic acid. This inhibition of arachidonic acid release from phospholipids may be the mechanism for the anti-inflammatory action of corticosteroids.
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The secretion rate of glucagon, estimated from glucagon removal under steady-state conditions, is approximately 1400 pg/min/kg of body weight in humans.
“Such estimation yields a value of approximately 1400 pg/min/kg of body weight in humans [35].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [35]
In the model, the arterial blood glucagon concentration is 0.81 pg/dl, which is consistent with the physiological range of blood glucagon concentration of between 0.25 and 1.5 pg/dl after 12 h fast.
“In the model, the arterial blood glucagon concentration is 0.81 pg/dl, which is consistent with the physiological range of blood glucagon concentration of between 0.25 and 1.5 pg/dl after 12 h fast [35].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [35]
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- Authors
- Fisher, M., Sherwin, R. S., Hendler, R., & Felig, P.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1976-05
- Volume
- 73
- Issue
- 5
- Pages
- 1735-1739
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC430375
- OpenAlex
- W2136764645
- Cited by
- 78
- References
- 15
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- glucagon, starvation, serum, prostaglandin synthesis, cortisol, arachidonic acid release, phospholipids, mouse fibroblasts
- MeSH terms
- Adult, Blood Glucose, Fasting, Female, Glucagon, Humans, Insulin, Kinetics, Male, Metabolic Clearance Rate, Middle Aged, Obesity
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