The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell

Metabolic effects of long-term somatostatin infusion in man

Gerich, J. E. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80179-5 · Cited by 24

The Pathology of Juvenile Diabetes

LeCompte, P. M., & Gepts, W. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2325-9_15 · Cited by 24

The Amino Acid-Induced Secretion of Glucagon

Assan, R., Marre, M., & Gormley, M. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_2 · Cited by 24

Islet-cell abnormalities in non-insulin-dependent diabetes mellitus

Raskin, P. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90578-9 · Cited by 23

Positively Charged Residues at Positions 12, 17, and 18 of Glucagon Ensure Maximum Biological Potency

Unson, C. G., Wu, C.-R., Cheung, C. P., & Merrifield, R. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10308 · Cited by 22

Glucagon and Diabetes

Raskin, P., & Unger, R. H. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31767-9 · Cited by 22

The hemodynamic basis of progressive renal disease.

Dunn, B. R., Anderson, S., & Brenner, B. M. (1986) · PubMed · Cited by 22

Glucagon antagonists

Andreu, D., & Merrifield, R. B. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11167.x · Cited by 21

Dose-kinetics of pancreatic glucagon responses to arginine and glucose in subjects with normal and impaired pancreatic B cell function

Assan, R., Efendić, S., Luft, R., & Cerasi, E. (1981) · Diabetologia · doi:10.1007/bf00257785 · Cited by 20

An immunocytochemical study of the cytogenesis of pancreatic endocrine cells in the lizard, Anolis carolinensis

Rhoten, W. B., & Hall, C. E. (1982) · American Journal of Anatomy · doi:10.1002/aja.1001630207 · Cited by 21

Some Hormonal Influences on Glucose and Ketone Body Metabolism in Normal Human Subjects

Johnston, D. G., Pernet, A., McCulloch, A., et al. (1982) · Novartis Foundation symposium · doi:10.1002/9780470720691.ch10 · Cited by 21

Somatostatin modulation of glucagon secretion and its importance in human glucose homeostasis

Gerich, J. E. (1978) · Metabolism · doi:10.1016/0026-0495(78)90059-8 · Cited by 19

The Pathology of Type I (Juvenile) Diabetes

Gepts, W., & LeCompte, P. M. (1985) · Springer eBooks · doi:10.1007/978-1-4757-0348-1_16 · Cited by 19

Chapter 20 Somatostatin

Veber, D. F., & Saperstein, R. (1979) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)61365-2 · Cited by 19

Therapy of insulin-independent diabetes mellitus: General considerations

Lebovitz, H. E., & Feinglos, M. N. (1980) · Metabolism · doi:10.1016/0026-0495(80)90173-0 · Cited by 19

Pathogenesis of diabetic glomerulopathy: hemodynamic considerations.

Hostetter, T. H. (1990) · PubMed · Cited by 19

SIRT1 activation attenuates α cell hyperplasia, hyperglucagonaemia and hyperglycaemia in STZ-diabetic mice

Zhang, Y., Thai, K., Jin, T., Woo, M., & Gilbert, R. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-32351-z · Cited by 20

Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice

Liang, Y. T., & Cincotta, A. H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801614 · Cited by 19

Effects of glucagon on amino acid metabolism in Japanese eels, Anguilla japonica

Inui, Y., & Yokote, M. (1977) · General and Comparative Endocrinology · doi:10.1016/0016-6480(77)90240-4 · Cited by 18

Glucotoxicity and α Cell Dysfunction: Involvement of the PI3K/Akt Pathway in Glucose-Induced Insulin Resistance in Rat Islets and Clonal αTC1-6 Cells

Shen, X., Li, H., Pan, L., Hong, J., Xiao, J., Hermansen, K., Jeppesen, P. B., & Li, G. (2011) · Endocrine Research · doi:10.3109/07435800.2011.610855 · Cited by 18

Extrapancreatic glucagon: Present status

Lund, A., & Knop, F. K. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.06.013 · Cited by 17

Solid phase peptide synthesis after 25 years: The design and synthesis of antagonists of glucagon

Merrifield, R. B. (1988) · Makromolekulare Chemie Macromolecular Symposia · doi:10.1002/masy.19880190104 · Cited by 17

THE REGULATION OF METABOLISM

Unger, R. H., DOBBS, R. E., & Orci, L. (1978) · Cited by 17

Glucagon, insulin and glucose homeostasis in the fetal lamb.

Bassett, J. M. (1977) · PubMed · Cited by 16

Factors Affecting Insulin-Regulated Hepatic Gene Expression

Guan, H.-P., & Chen, G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800101-1.00006-5 · Cited by 15

Hormonal and nutritional factors influencing glycogen deposition in primary cultures of rat liver parenchymal cells

Weber, C. A., & Kletzien, R. F. (1982) · Journal of Cellular Physiology · doi:10.1002/jcp.1041100313 · Cited by 15

Importance of glucagon in the control of futile cycling as studied in alloxan-diabetic dogs

Lickley, H. L. A., Kemmer, F. W., El-Tayeb, K. M. A., & Vranić, M. (1987) · Diabetologia · doi:10.1007/bf00274224 · Cited by 12

Investigations on isolated islets of langerhans in vitro

Hahn, H.-J., & ZIEGLER, M. (1977) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(77)90067-8 · Cited by 14

In vivo effects of glucose and insulin on secretion and gene expression of glucagon in rats

Magnan, C., Philippé, J., Kassis, N., Laury, M. C., Pénicaud, L., Gilbert, M., & Ktorza, A. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588284 · Cited by 15

Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon

Chatzipanteli, K., & Saggerson, D. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80225-7 · Cited by 13

Glucagon secretion from the perfused rat pancreas following acute and chronic streptozotocin

Weir, G. C., Atkins, R. F., & Martin, D. B. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80183-7 · Cited by 13

The effects of glucagon administration to nondiabetics and diabetics

Unger, R. H., Aydin, İ., Nakabayashi, H., Srikant, C. B., & Raskin, P. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80184-9 · Cited by 13

Glucagon release from rat pancreatic islets. A combined morphological and functional approach.

Carpentier, J. L., MALAISSE-LAGAE, F., & Müller, W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108870 · Cited by 13

Updating the Role of α-Cell Preproglucagon products on GLP-1 receptor–mediated insulin secretion

Sandoval, D. (2020) · Diabetes · doi:10.2337/dbi19-0027 · Cited by 12

Glucose‐lowering action through targeting islet dysfunction in type 2 diabetes: Focus on dipeptidyl peptidase‐4 inhibition

Åhrén, B. (2021) · Journal of Diabetes Investigation · doi:10.1111/jdi.13564 · Cited by 12

The impact of macronutrient composition on metabolic regulation: An Islet‐Centric view

dos Santos, K. C., Olofsson, C., da Cunha, J. P. M. C. M., Roberts, F., Catrina, S., Fex, M., Ekberg, N. R., & Spégel, P. (2022) · Acta Physiologica · doi:10.1111/apha.13884 · Cited by 14

Results of Pancreatic Blood Shunting into the Systemic Blood Flow in Insulin‐Dependent Diabetics

Galperin, E. I., Dyuzheva, Т. G., Petrovsky, P. F., et al. (1996) · HPB Surgery · doi:10.1155/1996/41904 · Cited by 12

Glucagon-secretion inhibition using somatostatin: An old hormone for the treatment of diabetes-associated pancreatectomy

Riveline, J., Boudou, P., Blondeau, B., et al. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.08.002 · Cited by 12

Hypercalcemic and Calcium‐Antagonistic Effects on Insulin Release and Oral Glucose Tolerance in Man

Andersson, D., Röjdmark, S., Hed, R., et al. (1982) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1982.tb01899.x · Cited by 12

The Metabolic Clearance Rate of Glucagon

Polonsky, K. S., Jaspan, J. B., & Rubenstein, A. H. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_17 · Cited by 12

Trace element metabolism in the chemically diabetic rat

Failla, M. L. (1983) · Biological Trace Element Research · doi:10.1007/bf02987213 · Cited by 11

Pure Glucagon Antagonists: Biological Activities and cAMP Accumulation Using Phosphodiesterase Inhibitors

Azizeh, B. Y., Tine, B. A. V., Trivedi, D. B., et al. (1997) · Peptides · doi:10.1016/s0196-9781(97)00131-9 · Cited by 11

Treatment of diabetes mellitus: The future

Raskin, P. (1979) · Metabolism · doi:10.1016/0026-0495(79)90186-0 · Cited by 11

Abnormal Lipid Accumulation Within the Small Intestinal Mucosa of Children With Juvenile-Onset Diabetes Mellitus

Bobo, R. C. (1977) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1977.02120220028003 · Cited by 10

Fine structural studies of the islets of Langerhans in the Djungarian hamster (Phodopus sungorus)

Voss, K., Herberg, L., & Kern, H. F. (1978) · Cell and Tissue Research · doi:10.1007/bf00222428 · Cited by 10

Glucagon in Diabetes Mellitus

Unger, R. H., & Orci, L. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_22 · Cited by 11

Control of pancreatic IRG secretion in vivo

Gerich, J. E. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80160-6 · Cited by 10

A comparison of insulin suppression tests performed with somatostatin and octreotide with particular reference to tolerability

Hwu, C., Kwok, C., Chiang, S.-C., Wang, P.-Y., Hsiao, L.-C., Lee, S.-H., Lin, S., & Ho, L.-T. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00238-2 · Cited by 10

Alpha cell function in diabetes mellitus

Gerich, J. E. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80181-3 · Cited by 10

Ketosis-Prone Atypical Diabetes: Glucagon Is There, Too

Lefèbvre, P. (2012) · Diabetes Care · doi:10.2337/dc12-1696 · Cited by 9

Inquiries into the Pathogenesis of Gestational Diabetes

Metzger, B. E., & Freinkel, N. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9110-8_28 · Cited by 9

Synthesis and hormonal activity of [Tyr 22] glucagon and [desHis 1, Tyr 22] glucagon

LU, G., Mojsov, S., & Merrifield, R. B. (1987) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1987.tb02282.x · Cited by 9

Plasma glucagon in diabetes of haemochromatosis: too low or too high?

Müller, W., Berger, M., Cüppers, H. J., Berchtold, P., Strohmeyer, G. W., Renold, A. E., Hofstetter, J. R., & Gonvers, J. J. (1979) · Gut · doi:10.1136/gut.20.3.200 · Cited by 8

The development and regulation of the endocrine pancreas

Hirsch, H. J., Loo, S., & Gabbay, K. H. (1977) · The Journal of Pediatrics · doi:10.1016/s0022-3476(77)81356-5 · Cited by 8

Histochemistry and Electron Microscopy of Islets

Boquist, L. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2325-9_6 · Cited by 8

9. ASSEMBLY AND SECRETION OF HEPATIC VERY-LOW-DENSITY LIPOPROTEIN

Gibbons, G. F. (2004) · Principles of medical biology · doi:10.1016/s1569-2582(04)15009-5 · Cited by 8

Glucagon

Harris, V., Faloona, G. R., & Unger, R. H. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-379260-0.50039-x · Cited by 8

Lipocalin-type prostaglandin D2 synthase reduces glucagon secretion in alpha TC-1 clone 6 cells via the DP1 receptor

Davani, D., Kumar, S., Palaia, T. A., Hall, C. E., & Ragolia, L. (2015) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2015.09.019 · Cited by 7

Hypoglycemic activity of l-α-(3,4- dimethoxyphenethylaminomethyl)-2- hydroxybenzylalcohol 12 fumarate (TA-078) in the mouse, rat and dog

Iwai, H., Inamasu, M., Totsuka, T., Shimazaki, T., Morita, T., & Takeyama, S. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90587-7 · Cited by 7

The 24-Hour Effects of Glyburide Chlorpropamide After Chronic Treatment of Type II Diabetic Patients

Prosser, P. R., Kosola, J. W., & Bowers, C. Y. (1985) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198505000-00001 · Cited by 7

Diazepam: Invitro effects on glucagon and insulin release

Petrack, B., Czernik, A. J., Itterly, W., et al. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90211-4 · Cited by 7

Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes

Lickley, H. L. A., Kemmer, F. W., Doi, K., & Vranić, M. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.4.e424 · Cited by 6

Effects of anagliptin on plasma glucagon levels and gastric emptying in patients with type 2 diabetes: An exploratory randomized controlled trial versus metformin

Nakagawa, T., Nagai, Y., Yamamoto, Y. L., Miyachi, A., Hamajima, H., Mieno, E., Takahashi, M., Inoue, E., & Tanaka, Y. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107892 · Cited by 6

The Nature of Diabetes

Bloom, A. (1978) · Journal of the Royal Society of Medicine · doi:10.1177/014107687807100304 · Cited by 6

Decreased glucagon-stimulated cyclic AMP production by isolated liver cells of rats with type 2 diabetes

Portha, B., Chamras, H., Broer, Y., Picon, L., & Rosselin, G. (1983) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(83)90095-3 · Cited by 6

Hepatotrophic Factors: Implications for Diabetes Mellitus

Johnston, D. G., JOHNSON, G. A., & Alberti, K. G. M. M. (1978) · Novartis Foundation symposium · doi:10.1002/9780470720363.ch18 · Cited by 6

Glucagon and somatostatin

Unger, R. H. (1978) · Disease-a-Month · doi:10.1016/s0011-5029(78)80006-6 · Cited by 6

Ambiguous effects of colchicine and vincristine upon A2-cell response to arginine

Assan, R., Soufflet, E., Ballerio, G., et al. (1978) · Diabetologia · doi:10.1007/bf01263450 · Cited by 6

The physiological function of glucagon

Alberti, K. G. M. M., & Nattrass, M. (1977) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1977.tb01590.x · Cited by 6

The milieu interieur and the islets of Langerhans

Unger, R. H. (1981) · Diabetologia · doi:10.1007/bf01789106 · Cited by 6

Increased somatostatin secretion from pancreatic islets of streptozotocin-diabetic rats in response to glucose

SCHAUDER, P., McIntosh, C. H. S., Herberg, L., et al. (1980) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(80)90040-4 · Cited by 5

Localization of human pancreatic polypeptide in an argyrophilic fourth cell type in islets of the rat pancreas

Schweisthal, M. R., Schweisthal, J. V., & Frost, C. C. (1978) · American Journal of Anatomy · doi:10.1002/aja.1001520206 · Cited by 5

Glucagon and Blood Glucose: Insights from Artificial Pancreas Studies

Felig, P., & SHERWIN, R. S. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-6-856 · Cited by 5

Glucagon—New Concepts About an “Old” Hormone

ALFORD, F. P., & Chisholm, D. J. (1979) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1979.tb04210.x · Cited by 5

Somatostatin and Diabetes Mellitus: The Role of Glucagon in Diabetic Hyperglycemia and Glucose Intolerance

Wahren, J. (1976) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365517609054470 · Cited by 5

Maturity-onset diabetes mellitus — Toward a physiologically appropriate management

McCarty, M. F. (1981) · Medical Hypotheses · doi:10.1016/0306-9877(81)90134-1 · Cited by 4

Glucagon and Amino Acid Metabolism

Cahill, G. F., Aoki, T. T., & Smith, R. J. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68866-9_18 · Cited by 4

Glucagon and Glucagon‐like Peptide Production and Degradation

Kieffer, T. J., Hussain, M. A., & Habener, J. F. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070208 · Cited by 4

Pancreatic A cell response to arginine in the hibernating hedgehog (Erinaceus europaeus)

Hoo-Paris, R., Hamsany, M., Castex, C., et al. (1983) · General and Comparative Endocrinology · doi:10.1016/0016-6480(83)90169-7 · Cited by 4

[A-cell-hyperplasia of islets of Langerhans on rabbits after immunisation with glucagon (author's transl)].

von Dorsche, H. H., & ZIEGLER, M. (1981) · PubMed · Cited by 4

The Search for Glucagon Antagonists

Amatruda, J. M., & Livingston, J. N. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-61150-6_8 · Cited by 3

Glucagon and insulin secretion during acid-base alterations

Rebolledo, O. R., & Gagliardino, J. J. (1983) · Acta Diabetologica · doi:10.1007/bf02581265 · Cited by 3

Role of Fibroblast Growth Factor 21 in Biology of Glucagon

Berglund, E. D., & Unger, R. H. (2013) · Diabetes · doi:10.2337/db12-1840 · Cited by 3

An overview of glucagon research

Valverde, I. (2016) · Diabetologia · doi:10.1007/s00125-016-3946-z · Cited by 3

A tribute to Roger H. Unger (1924–2020)

Scherer, P. E., & Newgard, C. B. (2020) · Journal of Clinical Investigation · doi:10.1172/jci145796 · Cited by 3

Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hyperfiltration

Anderson, S., & Brenner, B. M. (1988) · Springer eBooks · doi:10.1007/978-1-4757-1974-1_17 · Cited by 3

Signals for Glucagon Secretion

Bloom, S. R. (1978) · Novartis Foundation symposium · doi:10.1002/9780470720363.ch9 · Cited by 3

Editorial: Proglucagon-Derived Peptides

Flatt, P. R., Knop, F. K., & Tarasov, A. I. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.776871 · Cited by 3

Histochemistry and Electron Microscopy of Islets

Boquist, L., & Emdin, S. O. (1985) · Springer eBooks · doi:10.1007/978-1-4757-0348-1_7 · Cited by 3

The Nature of the A Cell Abnormality in Human Diabetes Mellitus

Chisholm, D. J., & ALFORD, F. P. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_42 · Cited by 3

Reflections of a Medicinal Chemist: Formative Years through Thirty-Seven Years Service in the Pharmaceutical Industry

Hirschmann, R. F., & Sturchio, J. L. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00239-x · Cited by 2

Glucagon-Like Peptide 1 Attenuates Lipotoxicity-Induced Islet Dysfunction in ApoE–/– Mice

Liu, F., Gong, L., Qin, W., Cui, C., Chen, L., & Zhang, M. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s262479 · Cited by 2

The normal range of the plasma immunoreactive glucagon level during a 75 g oral glucose tolerance test

Shima, K., Hirota, M., NAKAMURA, K., & Kodaira, T. (1985) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(86)80034-1 · Cited by 2

Use of Somatostatin in the Study of Carbohydrate Homeostasis in Man: Physiologic, Pathologic, and Therapeutic Considerations

Gerich, J. E. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-8849-8_15 · Cited by 1

Histology, Cell Types, and Functional Correlation of Islets of Langerhans

Wellmann, K. F., & Volk, B. W. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2325-9_4 · Cited by 2

Parenteral zinc and tissue metallothionein in normal and diabetic rats

Lin, L.-Y., & McCormick, C. C. (1986) · Biological Trace Element Research · doi:10.1007/bf02795531 · Cited by 2

Hormonal and metabolic control of hepatic carbohydrate metabolism

Jakob, A. (1981) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(81)90009-1 · Cited by 2

Endokrine Gewebe (Hormone)

Löffler, G., Petrides, P. E., & Weiss, L. (1985) · Springer eBooks · doi:10.1007/978-3-662-09350-4_22 · Cited by 2

Gastric-Glucagon: Physiology and Pathology

Lefèbvre, P. J., & LUYCKX, A. S. (1978) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7248-6_22 · Cited by 2

Histology, Cell Types, and Functional Correlation of Islets of Langerhans

Volk, B. W., & Wellmann, K. F. (1985) · Springer eBooks · doi:10.1007/978-1-4757-0348-1_4 · Cited by 2

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14