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The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell
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“The elevated glucagon concentrations in diabetes can be reduced but not normalized by insulin treatment (4,5)”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [4]
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Items 201–233 of 233
A-Zellenhyperplasie der Langerhansschen Inseln von Kaninchen nach Immunisierung mit Glukagon
von Dorsche, H. H., & Ziegler, M. L. (1981) · Acta Histochemica · doi:10.1016/s0065-1281(81)80086-4 · Cited by 2
Serum Glucagon after Arginine Infusion in Aged and Young Subjects
Ferrero, E., Casale, G., & de Nicola, P. (1980) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1980.tb00537.x · Cited by 1
Piro, S., Urbano, F., Folli, F. B., Finzi, G., Marselli, L., & Marchetti, P. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_31-1 · Cited by 1
Piro, S., Urbano, F., Folli, F. B., Finzi, G., Marselli, L., & Marchetti, P. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_31 · Cited by 1
Schiel, K. A. (2002) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00142-1 · Cited by 1
Glucagon and insulin secretion in potential diabetes
Tiengo, A., Fedele, D., Muggeo, M., Nosadini, R., Molinari, M., Garotti, M. C., & Crepaldi, G. (1978) · Acta Diabetologica · doi:10.1007/bf02581058 · Cited by 1
Felig, P. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.1977.03630170007003 · Cited by 1
Unger, R. H. (1976) · Springer eBooks · doi:10.1007/978-1-4684-7656-9_3 · Cited by 1
Self-citationEffect of Exercise on Fuel Utilization and Insulin Requirements
McLane, M. P., & Horwitz, D. L. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5499-4_9
Hürter, P. (1985) · Kliniktaschenbücher · doi:10.1007/978-3-662-21779-5_1
The Role of Hemodynamic Alterations in the Pathogenesis of Diabetic Glomerulopathy
Hostetter, T. H., & Brenner, B. M. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4199-4_8
Lafçi, L., & ALTAN, V. M. (1989) · Turkiye Klinikleri Tip Bilimleri Dergisi
The Issues Related to Abnormal A Cell Function in Diabetes Mellitus
Buchanan, K. D., & Trimble, E. R. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_39
Maclaren, N. K. (1976) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1976.02120130013002
Unger, R. H. (1977) · JAMA · doi:10.1001/jama.1977.03270370031008
Self-citationApproaches to Novel Antidiabetic Therapy
Petrack, B., Czernik, A. J., & Cassidy, J. (1983) · Transactions of the New York Academy of Sciences · doi:10.1111/j.2164-0947.1983.tb02796.x
Physiological role of pancreatic D cells (a mathematical study)
Mirzazade, V., Mamedov, A. A., & Atakishieva, M. K. (1988) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00834634
Morphologic Study of Glucagon Release
Carpentier, J. L., MALAISSE-LAGAE, F., Müller, W., & Orci, L. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_2
Анищенко, Т. Г., & Artemenko, O. V. (1977) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00801692
Insulin secretion : regulation of paracrine interrelation
Tan, K. S. (1982) · Surrey Research Insight Open Access (The University of Surrey)
Insulin, Glucagon, and Somatostatin Interaction in Diabetes
Raskin, P. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-187820-7.50024-3
Studies on the regulation of insulin secretion by glucagon
Tsiolakis, D. (1979) · Surrey Research Insight Open Access (The University of Surrey)
Failla, M. L. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-629050-9.50011-9
Unger, R. H. (1978) · Springer eBooks · doi:10.1007/978-1-4684-2499-7_3
Self-citationAssal, J. ‐., & Froesch, E. R. (1986) · Springer eBooks · doi:10.1007/978-3-642-70509-0_13
Löffler, G., Petrides, P. E., & Weiss, L. (1979) · Springer eBooks · doi:10.1007/978-3-662-09352-8_22
EFFECTS OF INSULIN ON GLUCAGON ACTION IN RAT LIVER
(2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1978.tb07390.x
Insulin binding to target cells
Pagano, G., & Cassader, M. (1979) · La Ricerca in Clinica e in Laboratorio · doi:10.1007/bf02904909
D’Souza, N. C., Hoffman, E. G., ATHERLEY, S. C., Champsi, S., ALEALI, N., Liggins, R., Chan, O. T. M., & Riddell, M. C. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.71012
“Poorly controlled T2D stems from reduced insulin secretion relative to insulin needs [19], elevated glucagon levels post meals [20, 21] and possibly elevated somatostatin secretion during both hypo-and hyperglycaemia [22–25], albeit the latter is difficult to confirm in vivo because of technical…”
Pancreatic islets: new discoveries for innovative treatments of diabetes?
Scharfmann, R., & Zaldumbide, A. (2026) · Diabetologia · doi:10.1007/s00125-026-06839-7
FATEHI, S., Rocheleau, J. V., & Riddell, M. C. (2026) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70384
“In brief, the glucagon switch-on/switch-off hypothesis proposes that a rapid decrease in insulin (the switch-off) from pancreatic β -cells is necessary to trigger glucagon secretion from the neighboring α -cells during hypoglycemia [ 63 ].”
Lazarus, L., Kraegen, E. W., Meler, H., et al. (1977) · Springer eBooks · doi:10.1007/978-1-4612-6366-1_44
Metadata
- Authors
- Unger, R. H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Unger, Roger H
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1976-02-01
- Volume
- 25
- Issue
- 2
- Pages
- 136-151
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2011393897
- Cited by
- 234
- References
- 0
- Citations by year
- 2026: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 53.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- alpha cells, pancreatic islets, diabetes mellitus, insulin secretion, glucagon
- MeSH terms
- Adult, Animals, Diabetes Mellitus, Diabetes Mellitus, Type 1, Digestive System, Glucagon, Glucose, Humans, Islets of Langerhans, Pancreas, Pancreatectomy, Diabetic Ketoacidosis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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