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The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell
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“The elevated glucagon concentrations in diabetes can be reduced but not normalized by insulin treatment (4,5)”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [4]
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Hostetter, T. H., Rennke, H. G., & Brenner, B. M. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90490-9 · Cited by 800
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670
Self-citationRegulatory Peptides of the Hypothalamus
Vale, W., RIVIER, C. L., & Brown, M. (1977) · Annual Review of Physiology · doi:10.1146/annurev.ph.39.030177.002353 · Cited by 392
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The pancreatic islets in diabetes
Gepts, W., & LeCompte, P. M. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90417-4 · Cited by 348
Unger, R. H., & Orci, L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198106183042504 · Cited by 303
Self-citationAssembly and secretion of hepatic very-low-density lipoprotein
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The glucose paradox. Is glucose a substrate for liver metabolism?
Katz, J. J., & McGarry, J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111610 · Cited by 278
The somatostatin-secreting pancreatic δ-cell in health and disease
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Hirschmann, R. F. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199112781 · Cited by 227
Role of glucagon in the pathogenesis of diabetes: The status of the controversy
Unger, R. H. (1978) · Metabolism · doi:10.1016/0026-0495(78)90291-3 · Cited by 216
Self-citationAmino acid transport in isolated rat hepatocytes
Kilberg, M. S. (1982) · The Journal of Membrane Biology · doi:10.1007/bf01871236 · Cited by 215
Effect of glucagon on glucose production during insulin deficiency in the dog.
Cherrington, A. D., LACY, W. W., & Chiasson, J. L. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109174 · Cited by 210
Hyperglucagonemia and Its Suppression
Raskin, P., & Unger, R. H. (1978) · New England Journal of Medicine · doi:10.1056/nejm197808312990901 · Cited by 197
Self-citationRegulation of glucagon secretion by glucose: paracrine, intrinsic or both?
Walker, J. N., Ramracheya, R. D., Zhang, Q., Johnson, P., Braun, M., & Rorsman, P. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01450.x · Cited by 180
Glucagon is the key factor in the development of diabetes
Lee, Y. H., Wang, M.-Y., Yu, X., & Unger, R. H. (2016) · Diabetologia · doi:10.1007/s00125-016-3965-9 · Cited by 167
Self-citationParadoxical Stimulation of Glucagon Secretion by High Glucose Concentrations
Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159
2 Intra-islet insulin—glucagon—somatostatin relationships
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Metabolic manifestations of insulin deficiency do not occur without glucagon action
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Self-citationThe endocrine pancreas in chronic pancreatitis
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Hormonal Regulation of Cystathionine β-Synthase Expression in Liver
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Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist
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Pathophysiology of Diabetes Mellitus
Sherwin, R., & Felig, P. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31766-7 · Cited by 121
Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes
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Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin.
Sherwin, R. S., Hendler, R., DeFronzo, R. A., Wahren, J., & Felic, P. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.348 · Cited by 110
KATP-channels and glucose-regulated glucagon secretion
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Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.
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Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations
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Function and expression of somatostatin receptors of the endocrine pancreas
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“Somatostatin in therapy of diabetes mellitus Both type 1 and type 2 diabetic patients have impaired glucose-stimulated SST secretion which might contribute to impaired prandial suppression of glucagon (Unger and Orci 1975; Unger 1976; Unger 1975; Shah et al., 1999; Reaven et al., 1987).”
BackgroundSynthetic peptide antagonists of glucagon.
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Targeting the CNS to treat type 2 diabetes
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Hormonal Control of Ketogenesis
McGarry, J., & Foster, D. W. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0734-2_4 · Cited by 98
Hypoglycemia of Infancy and Nesidioblastosis
Hirsch, H. J., Loo, S., Evans, N., Crigler, J. F., Filler, R. M., & Gabbay, K. H. (1977) · New England Journal of Medicine · doi:10.1056/nejm197706092962305 · Cited by 96
Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo
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“Diabetes 59:1521–1527, 2010 The pancreatic -cell is the primary regulator of glucose homeostasis and glucagon secretion (1,2).”
BackgroundUrinary Excretion of Zinc, Copper and Iron in the Streptozotocin-Diabetic Rat
Lau, A. L., & Failla, M. L. (1984) · Journal of Nutrition · doi:10.1093/jn/114.1.224 · Cited by 86
The milieu interieur and the islets of Langerhans
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Human Genetic Disorders That Feature Premature Onset and Accelerated Progression of Biological Aging
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Hormonal Interactions in the Regulation of Blood Glucose
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Identification of an essential serine residue in glucagon: implication for an active site triad.
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Hanna, A., Zinman, B., NAKHOODA, A. F., Minuk, H. L., Stokes, E. F., Albisser, A. M., LEIBEL, B. S., & Marliss, E. B. (1980) · Metabolism · doi:10.1016/0026-0495(80)90005-0 · Cited by 58
Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes
Jia, Y., Liu, Y., Feng, L., Sun, S., & Sun, G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.928016 · Cited by 63
Treatment of Type 1 Diabetic Patients with Glucagon-Like Peptide-1 (GLP-1) and GLP-1R Agonists
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Glucose Dependence of the Regulated Secretory Pathway in αTC1-6 Cells
McGirr, R., Ejbick, C. E., Carter, D. E., Andrews, J. D., Nie, Y., Friedman, T. C., & Dhanvantari, S. (2005) · Endocrinology · doi:10.1210/en.2005-0402 · Cited by 55
Unger, R. H. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.1977.03630160050012 · Cited by 55
Self-citationAndersson, D., & Röjdmark, S. (1981) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1981.tb09771.x · Cited by 52
Suppression of Ca2+ oscillations in glucagon-producing α2-cells by insulin/glucose and amino acids
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GLUCOSE-INDUCED HYPERKALÆMIA: A HAZARD FOR DIABETICS?
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Zinc, iron, and copper absorption in the streptozotocin-diabetic rat
Craft, N. E., & Failla, M. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.244.2.e122 · Cited by 49
Glucagon‐like peptide‐1 receptor agonists for type 2 diabetes: A rational drug development
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Factors controlling gastric-glucagon release.
Lefèbvre, P. J., & LUYCKX, A. S. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108690 · Cited by 48
Chemically and Hormonally Induced Diabetes
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The Role of Glucagon in the Endogenous Hyperglycemia of Diabetes Mellitus
Unger, R. H. (1977) · Annual Review of Medicine · doi:10.1146/annurev.me.28.020177.001003 · Cited by 47
Self-citationDighe, R. R., Rojas, F. J., Birnbaumer, L., et al. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111286 · Cited by 46
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Extrapancreatic Glucagon and Glucagonlike Immunoreactivity in Depancreatized Dogs
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Insights from a Successful Case of Intrahepatic Islet Transplantation into a Type 1 Diabetic Patient
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Localization of four polypeptide hormones in the saurian pancreas
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Four hormones in the pancreas of the lizard, Anolis carolinensis
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A New Biology of Diabetes Revealed by Leptin
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“Diabetes is characterized as a bihormonal disease (Unger 1976).”
BackgroundEffect of glucose on plasma glucagon and free fatty acids during prolonged exercise
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Metadata
- Authors
- Unger, R. H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Unger, Roger H
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1976-02-01
- Volume
- 25
- Issue
- 2
- Pages
- 136-151
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2011393897
- Cited by
- 234
- References
- 0
- Citations by year
- 2026: 3 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 53.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- alpha cells, pancreatic islets, diabetes mellitus, insulin secretion, glucagon
- MeSH terms
- Adult, Animals, Diabetes Mellitus, Diabetes Mellitus, Type 1, Digestive System, Glucagon, Glucose, Humans, Islets of Langerhans, Pancreas, Pancreatectomy, Diabetic Ketoacidosis
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