Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man
Abstract
The basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (> 30 min). Time series analysis demonstrated a synchronous plasma glucose oscillation (mean amplitude 0.03 mmol/L) associated with short insulin cycles. The glucose changes seen in diabetic subjects were similar to the short plasma insulin cycles (< 10 min) observed in normal subjects. In contrast, the longer plasma insulin cycles (> 10 min) of normal subjects were associated with a plasma glucose oscillation that rose before the end of the cycle. The demonstration of insulin oscillations independent of preceding plasma glucose changes in both normal and diabetic subjects suggests a pancreatic oscillating mechanism or “pacemaker.” The associated glucose changes may reflect the entrainment, by the insulin cycles, of glucose production or utilization.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevation of plasma glucose by intravenous glucose infusion triggers oscillations in plasma insulin with a period of ~10 min.
“When blood samples are taken at high frequency (every min), it becomes clear that elevation of plasma glucose (by intravenous glucose infusion) triggers oscillations in plasma insulin with a period of ~10 min (363) (Figure 15C).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [363]
Cited by
Sorted by citations
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
The cell biology of systemic insulin function
Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201802095 · Cited by 471 · see citing works
“Activated Akt1,2 migrates to the cytosol and intracellular membranes (Zheng and Cartee, 2016), where it phosphorylates AS160, a substrate of 160 kD more appropriately named TBC1D4 (Sano et al., 2003; Lansey et al., 2012).”
BackgroundAge-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk
Chia, C. W., Egan, J. M., & Ferrucci, L. (2018) · Circulation Research · doi:10.1161/circresaha.118.312806 · Cited by 454 · see citing works
The physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349 · see citing works
Ravier, M. A., Güldenagel, M., Charollais, A., Gjinovci, A., Caille, D., Söhl, G., Wollheim, C. B., Willecke, K., Henquin, J.-C., & Meda, P. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1798 · Cited by 360 · see citing works
Islet β cell mass in diabetes and how it relates to function, birth, and death
Weir, G. C., & Bonner‐Weir, S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12031 · Cited by 296 · see citing works
Meier, J. J., Veldhuis, J. D., & Butler, P. C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1649 · Cited by 261 · see citing works
Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes
Pørksen, N., Hollingdal, M., Juhl, C., Butler, P., Veldhuis, J. D., & Schmitz, O. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s245 · Cited by 223 · see citing works
Gut hormones and diabetes mellitus
Creutzfeldt, W., & Nauck, M. (1992) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610080206 · Cited by 176 · see citing works
Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling
Matveyenko, A. V., Liuwantara, D., Gurlo, T., Kirakossian, D., Dalla Man, C., Cobelli, C., White, M. F., Copps, K. D., Volpi, E., Fujita, S., et al. (2012) · Diabetes · doi:10.2337/db11-1462 · Cited by 163 · see citing works
Plasma glucose and insulin response to macronutrients in nondiabetic and NIDDM subjects
Nuttall, F. Q., & Gannon, M. C. (1991) · Diabetes Care · doi:10.2337/diacare.14.9.824 · Cited by 152 · see citing works
SIMON, C., BRANDENBERGER, G., & FOLLENIUS, M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-4-669 · Cited by 147 · see citing works
O'Meara, N. M., Sturis, J., Van Cauter, E., & Polonsky, K. S. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116560 · Cited by 132 · see citing works
Dula, S. B., Jecmenica, M., Wu, R., Jahanshahi, P., Verrilli, G. M., Carter, J. D., Brayman, K. L., & Nunemaker, C. S. (2010) · Cell Calcium · doi:10.1016/j.ceca.2010.07.007 · Cited by 83 · see citing works
Cell coupling in mouse pancreatic β-cells measured in intact islets of Langerhans
Zhang, Q., Galvanovskis, J., Abdulkader, F., Partridge, C. J., Göpel, S. O., Eliasson, L., & Rorsman, P. (2008) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2008.0110 · Cited by 80 · see citing works
Transitions between bursting modes in the integrated oscillator model for pancreatic β-cells
Marinelli, I., Vo, T., Gerardo-Giorda, L., & Bertram, R. (2018) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2018.06.017 · Cited by 28 · see citing works
- Authors
- Lang, D. A., Matthews, D. R., Burnett, M., & Turner, R. C.
- Affiliations
- University of Oxford (GB)
- ORCID
- Matthews, D R
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1981-05-01
- Volume
- 30
- Issue
- 5
- Pages
- 435-439
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2123410845
- Cited by
- 279
- References
- 0
- Citations by year
- 2026: 4 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 12 · 2013: 5 · 2012: 9
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- insulin oscillations, type 2 diabetes, basal insulin secretion, glucose production, glucose utilization, time series analysis
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Humans, Insulin, Kinetics, Reference Values
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
