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Cited by 147Pancreatic function and diabetesDiabetes Management and ResearchDiabetes Treatment and Management

Ultradian Oscillations of Plasma Glucose, Insulin, and C Peptide in Man During Continuous Enteral Nutrition

SIMON, C., BRANDENBERGER, G., FOLLENIUS, M.·1987·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-64-4-669
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Abstract

The profiles of plasma glucose, insulin, and C-peptide were studied in normal men receiving continuous enteral nutrition. Large oscillations occurred with periods of 53-113 min. Their mean amplitudes, expressed as a percentage of the 24-h mean, were as high as 20% for glucose, 54% for insulin, and 56% for C-peptide. The oscillations of plasma insulin levels throughout the 24 h were concomitant with those of C-peptide. Rapid 8- to 14-min plasma insulin and glucose oscillations were smaller in magnitude and could only be detected in some segments of the longer period oscillations. These results indicate that in addition to the previously described 8- to 14-min oscillations, plasma glucose, insulin, and C-peptide oscillate at a mean 80-min periodicity in man during continuous enteral nutrition. These oscillations may reflect a pancreatic oscillatory mechanism and/or cyclic variations in gastrointestinal motility or peripheral glucose uptake.

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Crossref · 10.1210/jcem-64-4-669

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    From Sleep and metabolic function (2012) · cites this paper as [151]

  • The 24-hour cortisol profile is only modestly affected by the presence or absence of sleep.

    “As shown in Fig. 1b, this profile is only modestly affected by the presence or absence of sleep.”

    From Sleep and metabolic function (2012) · cites this paper as [151]

  • Under constant glucose infusion, the major cause of decreased glucose tolerance during sleep is decreased glucose utilization.

    “Under these experimental conditions, the major underlying cause of the decrease in glucose tolerance is decreased glucose utilization.”

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Related

Authors
SIMON, C., BRANDENBERGER, G., & FOLLENIUS, M.
Affiliations
Centre National de la Recherche Scientifique (FR)
ORCID
SIMON, C.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1987-04
Volume
64
Issue
4
Pages
669-674
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-64-4-669
OpenAlex
W2038591578
Cited by
147
References
33
Citations by year
2025: 1 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
7.02
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
ultradian oscillations, plasma glucose, insulin, C-peptide, continuous enteral nutrition, gastrointestinal motility, peripheral glucose uptake, circadian rhythm
MeSH terms
Activity Cycles, Adult, Blood Glucose, C-Peptide, Circadian Rhythm, Enteral Nutrition, Humans, Insulin, Male

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