Cited by 455Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk

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Chia, Chee W., Egan, Josephine M., Ferrucci, Luigi·2018·Circulation Research

Abstract

Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in life expectancy with a simultaneous increase in the prevalence of diabetes mellitus in the older population. This large number of older individuals with diabetes mellitus is problematic given that CVD risk associated with aging and diabetes mellitus. In this review, we summarize epidemiological data relating to diabetes mellitus and CVD, with an emphasis on the aging population. We then present data on hyperglycemia as a risk factor for CVD and review the current knowledge of age-related changes in glucose metabolism. Next, we review the role of obesity in the pathogenesis of age-related glucose dysregulation, followed by a summary of the results from major randomized controlled trials that focus on cardiovascular risk reduction through glycemic control, with a special emphasis on older adults. We then conclude with our proposed model of aging that body composition changes and insulin resistance link possible dysregulation of physiological pathways leading to obesity and diabetes mellitus—both forms of accelerated aging—and risks for CVD.

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  1. [15]World Health Organization. Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus. http://www.who.int/diabetes/publications/diagnosis_diabetes2011/en/. 2011. 26158184
  2. [179]Knatterud GL, Klimt CR, Goldner MG, Hawkins BS, Weisenfeld S, Kreines K and Haddock L. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes.V. Evaluation of phenformin therapy. Diabetes. 1975; 24: 65– 184.1090475

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Authors
Chia, C. W., Egan, J. M., & Ferrucci, L.
Affiliations
National Institutes of Health (US)
Corresponding author
Ferrucci, Luigi
Venue
Circulation Research
Published
2018-09-14
Volume
123
Issue
7
Pages
886-904
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2891409258
Cited by
454
References
208
Citations by year
2026: 61 · 2025: 71 · 2024: 72 · 2023: 82 · 2022: 70 · 2021: 38 · 2020: 42 · 2019: 15 · 2018: 1 · 2013: 1
FWCI
3.71
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (Z01AG000015)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
aging, glucose metabolism, hyperglycemia, cardiovascular risk, diabetes mellitus, older adults, obesity, insulin resistance, glycemic control, body composition, accelerated aging, cardiovascular disease
MeSH terms
Adipose Tissue, Age Factors, Aging, Animals, Blood Glucose, Cardiovascular Diseases, Health Status, Humans, Hyperglycemia, Insulin, Insulin Resistance, Models, Biological, Obesity, Prognosis, Risk Factors, Biomarkers, Prevalence, Risk Assessment, Adiposity

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