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Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise
Abstract
We studied glucose metabolism in non-insulin-dependent diabetic (NIDDM) men with and without glycogen-depleting cycle exercise 12 h beforehand and have compared the results to our previous data in lean and obese subjects. Rates of total glucose utilization, glucose oxidation, nonoxidative glucose disposal (NOGD), glucose metabolic clearance rate (MCR), and endogenous glucose production (EGP) were determined with a "two-level" insulin-clamp technique (100-min infusions at 40 and 400 mU X m-2 X min-1) combined with indirect calorimetry and D-3-[3H]glucose infusion. Muscle biopsy specimens from vastus lateralis were analyzed for glycogen content and glycogen synthase activity before and after insulin infusions. After exercise, NIDDM subjects had muscle glycogen concentrations comparable with those of lean and obese subjects. The activation of glycogen synthase both by prior exercise and insulin infusion was similar to lean controls. After exercise, total glucose disposal was significantly increased during the 40-mU X m-2 X min-1 infusion (P less than .05), but the increase observed during the 400-mU X m-2 X min-1 infusion was not significant. These increases after exercise were the result of significantly higher NOGD during both levels of insulin infusion. The MCR of glucose during both insulin infusions was reduced in NIDDM compared with lean subjects but was very similar to that in obese nondiabetics. Basal EGP was significantly reduced on the morning after exercise (4.03 +/-…
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“In the postabsorptive state exercise of moderate intensity has been shown to decrease plasma glucose concentrations and is followed by an increase in insulin sensitivity [1-5].”
From The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients (1997) · cites this paper as [4]
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Metadata
- Authors
- Devlin, J. T., Hirshman, M., Horton, E. D., & Horton, E. S.
- Affiliations
- University of Vermont (US)
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1987-04-01
- Volume
- 36
- Issue
- 4
- Pages
- 434-439
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2041265416
- Cited by
- 342
- References
- 0
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 6
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01am026317-05)
- U.S. Public Health Service (5-F32-07034-02, R23-29866-03)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes, insulin sensitivity, glucose metabolism, nonoxidative glucose disposal, endogenous glucose production, glucose oxidation, muscle glycogen, glycogen synthase, peripheral insulin sensitivity, fasting blood glucose, glucose storage, vastus lateralis, obesity, insulin resistance, glucose metabolic clearance rate
- MeSH terms
- Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Physical Exertion, Glucose, Glycogen, Glycogen Synthase, Humans, Insulin, Insulin Resistance, Male, Muscles
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