CoChat
Sign Up
Cited by 342Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerDiabetes Management and Research

The DOI matches its Crossref record.

Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise

Devlin, John T, Hirshman, Michael, Horton, Elizabeth D, Horton, Edward S·1987·Diabetes
DOI 10.2337/diab.36.4.434
Open this paper in CoChat — free account

Abstract

We studied glucose metabolism in non-insulin-dependent diabetic (NIDDM) men with and without glycogen-depleting cycle exercise 12 h beforehand and have compared the results to our previous data in lean and obese subjects. Rates of total glucose utilization, glucose oxidation, nonoxidative glucose disposal (NOGD), glucose metabolic clearance rate (MCR), and endogenous glucose production (EGP) were determined with a "two-level" insulin-clamp technique (100-min infusions at 40 and 400 mU X m-2 X min-1) combined with indirect calorimetry and D-3-[3H]glucose infusion. Muscle biopsy specimens from vastus lateralis were analyzed for glycogen content and glycogen synthase activity before and after insulin infusions. After exercise, NIDDM subjects had muscle glycogen concentrations comparable with those of lean and obese subjects. The activation of glycogen synthase both by prior exercise and insulin infusion was similar to lean controls. After exercise, total glucose disposal was significantly increased during the 40-mU X m-2 X min-1 infusion (P less than .05), but the increase observed during the 400-mU X m-2 X min-1 infusion was not significant. These increases after exercise were the result of significantly higher NOGD during both levels of insulin infusion. The MCR of glucose during both insulin infusions was reduced in NIDDM compared with lean subjects but was very similar to that in obese nondiabetics. Basal EGP was significantly reduced on the morning after exercise (4.03 +/-…

Overview

Integrity signals

Registry

Crossref · 10.2337/diab.36.4.434

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Devlin, J. T., Hirshman, M., Horton, E. D., & Horton, E. S.
Affiliations
University of Vermont (US)
ORCID
Venue
Diabetes
Publisher
American Diabetes Association
Published
1987-04-01
Volume
36
Issue
4
Pages
434-439
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
DOI
10.2337/diab.36.4.434
OpenAlex
W2041265416
Cited by
342
References
0
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 6
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2r01am026317-05)
  • U.S. Public Health Service (5-F32-07034-02, R23-29866-03)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
type 2 diabetes, insulin sensitivity, glucose metabolism, nonoxidative glucose disposal, endogenous glucose production, glucose oxidation, muscle glycogen, glycogen synthase, peripheral insulin sensitivity, fasting blood glucose, glucose storage, vastus lateralis, obesity, insulin resistance, glucose metabolic clearance rate
MeSH terms
Adult, Blood Glucose, C-Peptide, Diabetes Mellitus, Type 2, Physical Exertion, Glucose, Glycogen, Glycogen Synthase, Humans, Insulin, Insulin Resistance, Male, Muscles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review