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Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats
Abstract
Nonenzymatic glycosylation of structural proteins and the formation of advanced glycosylation end products (AGEs) have been involved in the pathogenesis of diabetic complications. We examined the effect of aminoguanidine, a potent inhibitor of AGE formation, on functional and structural abnormalities in peripheral nerve of streptozocin-induced diabetic rats. Diabetic rats were treated with daily injections of 25 mg/kg body wt s.c. aminoguanidine (AG)-sulfate for 16 wk and compared to untreated diabetic rats. AG treatment improved motor nerve conduction velocity in 12- and 16-wk diabetic rats despite no changes in body weight, blood glucose, and HbAIc levels. AG treatment inhibited an accumulation of fluorescent AGE in diabetic nerves, and morphometric analysis of the sural nerve showed a partial effect on myelinated fiber size and axonal atrophy. These findings suggest that AG may have a beneficial effect on diabetic neuropathy and nonenzymatic glycosylation of peripheral nerve proteins.
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Citations
Cited by
Diabetes-Related Microvascular and Macrovascular Diseases in the Physical Therapy Setting
Cade, W. T. (2008) · Physical Therapy · doi:10.2522/ptj.20080008 · Cited by 1,084
Bierhaus, A. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00233-2 · Cited by 555
Mechanism of diabetic neuropathy: Where are we now and where to go?
Yagihashi, S., Mizukami, H., & Sugimoto, K. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00070.x · Cited by 488
Self-citationMcCance, D. R., Dyer, D. G., Dunn, J. A., Bailie, K. E., Thorpe, S. R., Baynes, J. W., & Lyons, T. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116482 · Cited by 444
Prevention and Treatment of the Complications of Diabetes Mellitus
Clark, C. M., & Lee, D. A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321807 · Cited by 369
Metadata
- Authors
- Yagihashi, S., Kamijo, M., Baba, M., Yagihashi, N., & Nagai, K.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1992-01-01
- Volume
- 41
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2009340697
- Cited by
- 192
- References
- 0
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats. https://app.cochat.ai/papers/10.2337/diab.41.1.47
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- Yagihashi, S., Kamijo, M., Baba, M., Yagihashi, N., & Nagai, K. (1992). Effect of Aminoguanidine on Functional and Structural Abnormalities in Peripheral Nerve of STZ-Induced Diabetic Rats. Diabetes. https://doi.org/10.2337/diab.41.1.47
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