The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Insulin and Cortisol Promote Leptin Production in Cultured Human Fat Cells
Abstract
The aim of this study was to investigate the regulation of leptin expression and production in cultured human adipocytes using the model of in vitro differentiated human adipocytes. Freshly isolated human preadipocytes did not exhibit significant leptin mRNA and protein levels as assessed by reverse transcriptase (RT)-polymerase chain reaction (PCR) and radioimmunoassay (RIA). However, during differentiation induced by a defined adipogenic serum-free medium, cellular leptin mRNA and leptin protein released into the medium increased considerably in accordance with the cellular lipid accumulation. In fully differentiated human fat cells, insulin provoked a dose-dependent rise in leptin protein. Cortisol at a near physiological concentration of 10−8 mol/l was found to potentiate this insulin effect by almost threefold. Removal of insulin and cortisol, respectively, was followed by a rapid decrease in leptin expression, which was reversible after readdition of the hormones. These results clearly indicate that both insulin and cortisol are potent and possibly physiological regulators of leptin expression in human adipose tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro
Kolaczynski, J. W., Nyce, M. R., Considine, R. V., Boden, G., Nolan, J. J., Henry, R., Mudaliar, S. R., Olefsky, J., & Caro, J. F. (1996) · Diabetes · doi:10.2337/diab.45.5.699 · Cited by 700
Increased obese mRNA expression in omental fat cells from massively obese humans
Hamilton, B. S., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995) · Nature Medicine · doi:10.1038/nm0995-953 · Cited by 526
Cited by
Leptin and Obesity: Role and clinical implication.
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.585887 · Cited by 1,121
Leptin and reproduction: a review
Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03010-2 · Cited by 557
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
Insulin stimulates both leptin secretion and production by rat white adipose tissue
Barr, V. A., Malide, D., Zarnowski, M. J., Taylor, S. I., & Cushman, S. W. (1997) · Endocrinology · doi:10.1210/endo.138.10.5451 · Cited by 297
Seufert, J., Kieffer, T. J., Leech, C. A., Holz, G. G., Moritz, W., Ricordi, C., & Habener, J. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5460 · Cited by 278
Metadata
- Authors
- Wabitsch, M., Bo Jensen, P., Blum, W. F., Christoffersen, C. T., Englaro, P., Heinze, E., Rascher, W., Teller, W., Tornqvist, H., & Hauner, H.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1996-10-01
- Volume
- 45
- Issue
- 10
- Pages
- 1435-1438
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2119829902
- Cited by
- 472
- References
- 4
- FWCI
- 38.01
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
