Insulin stimulates both leptin secretion and production by rat white adipose tissue

Barr, Valarie A.; Malide, Daniela; Zarnowski, Mary Jane; Taylor, Simeon I.; Cushman, Samuel W.

doi:10.1210/endo.138.10.5451

Cited by 297Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Insulin stimulates both leptin secretion and production by rat white adipose tissue

Barr, Valarie A., Malide, Daniela, Zarnowski, Mary Jane, Taylor, Simeon I., Cushman, Samuel W.·1997·Endocrinology

DOI 10.1210/endo.138.10.5451

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Abstract

Leptin, the peptide encoded by the obese gene, is secreted by adipose cells and plays a role in regulating food intake, energy expenditure, and adiposity. Because earlier studies suggested that insulin increases the expression of leptin, we investigated the effect of insulin on leptin secretion by adipose tissue. Epididymal fat pads were incubated in vitro in the presence or absence of insulin over a 4-h time course. Insulin increased leptin secretion by about 80% at all time points studied. After 10 min of insulin treatment, the amount of tissue-associated leptin was lower in insulin-stimulated tissue, presumably due to the increased secretion. At later times, both tissue-associated leptin and total leptin production were higher in insulin-treated tissue. In untreated, isolated adipose cells, immunostaining of leptin was detected in the endoplasmic reticulum by confocal microscopy. After insulin treatment, there were two populations of cells. In many cells, leptin staining became fainter and was restricted to a narrow band near the plasma membrane. However, in other cells the leptin-staining pattern was unchanged. Leptin did not colocalize with GLUT4, the glucose transporter isoform found primarily in insulin-responsive cells, in either basal or insulin-stimulated adipose cells. In this study, insulin increased both secretion and production of leptin by adipose tissue fragments. Interestingly, insulin appeared to stimulate the transport of leptin from the endoplasmic reticulum rather than acting on a pool of regulated secretory vesicles. (Endocrinology 138: 4463-4472, 1997)

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Some of the positive effects of insulin on the reproductive system might derive from its ability to stimulate leptin secretion.
“therefore, some of the positive effects of insulin on the reproductive system might derive from its ability to stimulate leptin secretion.106”
From Pubertal development and regulation (2016) · cites this paper as [106]
Insulin is a major regulator of leptin production.
“Insulin is a major regulator of leptin production; therefore, some of the positive effects of insulin on the reproductive system might derive from its ability to stimulate leptin secretion.106”
From Pubertal development and regulation (2016) · cites this paper as [106]

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Printed in U.S.A. Copyright © 1998 by The Endocrine Society Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes*
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Dual Effect of Insulin on in Vitro Leptin Secretion by Adipose Tissue
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Identification and characterization of leptin-containing intracellular compartment in rat adipose cells
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Authors: Barr, V. A., Malide, D., Zarnowski, M. J., Taylor, S. I., & Cushman, S. W.
Affiliations: National Institutes of Health (US)
ORCID: Barr, Valarie A.
Taylor, Simeon I.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1997-10-01
Volume: 138
Issue: 10
Pages: 4463-4472
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.138.10.5451
OpenAlex: W2126095470
Cited by: 297
References: 36
Citations by year: 2025: 2 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 4 · 2012: 11
FWCI: 5.77
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: insulin, leptin, leptin secretion, white adipose tissue, epididymal adipose tissue, adipocytes, endoplasmic reticulum, GLUT4, obese gene, energy homeostasis
MeSH terms: Adipose Tissue, Animals, Endoplasmic Reticulum, Immunohistochemistry, Insulin, Male, Monosaccharide Transport Proteins, Muscle Proteins, Precipitin Tests, Proteins, Rats, Inbred Strains, Time Factors, Protein Biosynthesis, Microscopy, Confocal, Fluorescent Antibody Technique, Indirect, Leptin, Glucose Transporter Type 4, Rats

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Insulin stimulates both leptin secretion and production by rat white adipose tissue

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