The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance
Open accessAbstract
The product of the ob gene, leptin, is a hormone secreted by adipose tissue that acts in the hypothalamus to regulate the size of the body fat depot. Its central administration has been shown to decrease food intake and body weight, while favoring energy dissipation. As glucocorticoids are known to play a permissive role in the establishment and maintenance of obesity syndromes in rodents, it was hypothesized that they do so by restraining the effect of leptin. Leptin injected intracerebroventricularly as a bolus of 3 μg in normal rats induced modest reductions in body weight and food intake. In marked contrast, the same dose of leptin had very potent and long-lasting effects in decreasing both body weight and food intake when administered to adrenalectomized rats. Further, glucocorticoid supplementation of adrenalectomized rats dose-dependently inhibited these potent effects of leptin. These data suggest that glucocorticoids play a key inhibitory role in the action of leptin. Under normal conditions, this inhibitory influence of glucocorticoids may prevent lasting hypophagia. In obesity with degrees of hypercorticism, it may contribute to “leptin resistance,” whose etiology is still little understood.
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The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
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Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
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Overfeeding Rapidly Induces Leptin and Insulin Resistance
Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., & Rossetti, L. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2786 · Cited by 355
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Metadata
- Authors
- Zakrzewska, K. E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F., & Jeanrenaud, B.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1997-04-01
- Volume
- 46
- Issue
- 4
- Pages
- 717-719
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2010342389
- Cited by
- 315
- References
- 3
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zakrzewska, K. E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F., & Jeanrenaud, B. (1997). Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance. Diabetes. https://doi.org/10.2337/diab.46.4.717
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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