The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Glucocorticoids as Counterregulatory Hormones of Leptin: Toward an Understanding of Leptin Resistance
Open accessAbstract
The product of the ob gene, leptin, is a hormone secreted by adipose tissue that acts in the hypothalamus to regulate the size of the body fat depot. Its central administration has been shown to decrease food intake and body weight, while favoring energy dissipation. As glucocorticoids are known to play a permissive role in the establishment and maintenance of obesity syndromes in rodents, it was hypothesized that they do so by restraining the effect of leptin. Leptin injected intracerebroventricularly as a bolus of 3 μg in normal rats induced modest reductions in body weight and food intake. In marked contrast, the same dose of leptin had very potent and long-lasting effects in decreasing both body weight and food intake when administered to adrenalectomized rats. Further, glucocorticoid supplementation of adrenalectomized rats dose-dependently inhibited these potent effects of leptin. These data suggest that glucocorticoids play a key inhibitory role in the action of leptin. Under normal conditions, this inhibitory influence of glucocorticoids may prevent lasting hypophagia. In obesity with degrees of hypercorticism, it may contribute to “leptin resistance,” whose etiology is still little understood.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F. (1986) · Peptides · doi:10.1016/0196-9781(86)90149-x · Cited by 849
Cited by
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Leptin and reproduction: a review
Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03010-2 · Cited by 557
Overfeeding Rapidly Induces Leptin and Insulin Resistance
Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z., & Rossetti, L. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2786 · Cited by 355
The defence of body weight: a physiological basis for weight regain after weight loss
Sumithran, P., & Proietto, J. (2013) · Clinical Science · doi:10.1042/cs20120223 · Cited by 310
Inflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
The Protective Role of Exercise on Stress System Dysregulation and Comorbidities
TSATSOULIS, A., & FOUNTOULAKIS, S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1367.020 · Cited by 306
Pralong, F. P., Roduit, R., Waeber, G., Castillo, E., Mosimann, F., Thorens, B., & Gaillard, R. C. (1998) · Endocrinology · doi:10.1210/endo.139.10.6254 · Cited by 202
Leptin Rapidly Lowers Food Intake and Elevates Metabolic Rates in Lean and ob/ob Mice ,
Mistry, A. M., Swick, A. G., & Romsos, D. R. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.10.2065 · Cited by 188
Obesity, diabetes and the central nervous system
Porte Jr., D., Seeley, R. J., Woods, S. C., Baskin, D. G., Figlewicz, D. P., & Schwartz, M. W. (1998) · Diabetologia · doi:10.1007/s001250051002 · Cited by 186
Tsatsoulis, A., Mantzaris, M. D., Bellou, S., & Andrikoula, M. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.004 · Cited by 174
Associations Between Bipolar Disorder and Metabolic Syndrome: A Review
Taylor, V., & MacQueen, G. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0704 · Cited by 152
The Role of Leptin in Human Physiology
Rosenbaum, M., & Leibel, R. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411211 · Cited by 134
Yam, K. Y., Naninck, E. F. G., Abbink, M. R., la Fleur, S. E., Schipper, L., van den Beukel, J. C., Grefhorst, A., Oosting, A., van der Beek, E. M., Lucassen, P. J., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.12.012 · Cited by 78
Troglitazone Antagonizes Metabolic Effects of Glucocorticoids in Humans
Willi, S. M., Kennedy, A., Wallace, P., Ganaway, E., Rogers, N. L., & Garvey, W. T. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2895 · Cited by 77
Wallace, A. M., Tucker, P., Williams, D. M., Hughes, I. A., & Ahmed, S. F. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01790.x · Cited by 57
Huybrechts, I., De Vriendt, T., Breidenassel, C., Rogiers, J., Vanaelst, B., Cuenca-García, M., Moreno, L. A., González-Gross, M., Roccaldo, R., Kafatos, A., et al. (2014) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.014 · Cited by 20
Stachon, M., Fürstenberg, E., & Gromadzka-Ostrowska, J. (2006) · Endocrine · doi:10.1385/endo:30:1:69 · Cited by 15
Metadata
- Authors
- Zakrzewska, K. E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F., & Jeanrenaud, B.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 1997-04-01
- Volume
- 46
- Issue
- 4
- Pages
- 717-719
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2010342389
- Cited by
- 315
- References
- 3
- FWCI
- 7.65
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
