Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

Wojtaszewski, Jørgen F. P.; Nielsen, Pernille; Hansen, Bo F.; Richter, Erik A.; Kiens, Bente

doi:10.1111/j.1469-7793.2000.t01-1-00221.x

Cited by 437Metabolism, Diabetes, and CancerCardiovascular and exercise physiologyMuscle metabolism and nutrition

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Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

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Wojtaszewski, Jørgen F. P., Nielsen, Pernille, Hansen, Bo F., Richter, Erik A., Kiens, Bente·2000·The Journal of Physiology

DOI 10.1111/j.1469-7793.2000.t01-1-00221.xPMC PMC2270117

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Abstract

1. 5'-AMP-activated protein kinase (AMPK) has been suggested to play a key role in the regulation of metabolism in skeletal muscle. AMPK is activated in treadmill-exercised and electrically stimulated rodent muscles. Whether AMPK is activated during exercise in humans is unknown. 2. We investigated the degree of activation and deactivation of alpha-isoforms of AMPK during and after exercise. Healthy human subjects performed bicycle exercise on two separate occasions at either a low ( approximately 50% maximum rate of O2 uptake (VO2,max) for 90 min) or a high ( approximately 75% VO2,max for 60 min) intensity. Biopsies from the vastus lateralis muscle were obtained before and immediately after exercise, and after 3 h of recovery. 3. We observed a 3- to 4-fold activation of the alpha2-AMPK isoform immediately after high intensity exercise, whereas no activation was observed after low intensity exercise. The activation of alpha2-AMPK was totally reversed 3 h after exercise. In contrast, alpha1-AMPK was not activated during either of the two exercise trials. 4. The in vitro AMP dependency of alpha2-AMPK was significantly greater than that of alpha1-AMPK ( approximately 3- vs. approximately 2-fold). 5. We conclude that in humans activation of alpha2-AMPK during exercise is dependent upon exercise intensity. The stable activation of alpha2-AMPK, presumably due to the activation of an upstream AMPK kinase, is compatible with a role for this kinase complex in the regulation of skeletal muscle metabolism during exercise, whereas the lack of stable alpha1-AMPK activation makes this kinase complex a less likely candidate.

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AMPK activity increases rapidly and then returns to baseline levels within the first 3 h after high-intensity exercise.
“AMPK activity increases rapidly and then returns to baseline levels within the first 3 h after high-intensity exercise [63]”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [63]
The Results report that α2-AMPK activity increased 3- to 4-fold after 60 minutes of high-intensity bicycle exercise and returned to basal levels after 3 hours of recovery. The paper does not establish how rapidly activity increased, and it reports that α1-AMPK activity did not increase; the claim omits that isoform distinction. (LLM, conf=0.87)
Experimental — accuracy not yet measured
High-intensity exercise activates both AMPK and PGC-1α to a greater extent than low-intensity exercise in skeletal muscle.
“High-intensity exercise activates both AMPK and peroxisome proliferator-activated receptor co-activator (PGC-1α) to a greater extent than low-intensity exercise in skeletal muscle”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Wojtaszewski et al., 2000
The Results report that high-intensity exercise activated α2-AMPK in human skeletal muscle, while low-intensity exercise did not; neither intensity activated α1-AMPK. The paper does not report PGC-1α activation, so it supports only the AMPK portion of the claim. (LLM, conf=0.90)
Experimental — accuracy not yet measured
AMPK is activated during exercise in both rodents and humans.
“Consistent with this, AMPK is activated during exercise in both rodents and humans [51-60], in an intensity-dependent manner [57,59-61].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [57]
AMPK activation during exercise is intensity-dependent.
“Consistent with this, AMPK is activated during exercise in both rodents and humans [51-60], in an intensity-dependent manner [57,59-61].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [57]

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Authors: Wojtaszewski, J. F. P., Nielsen, P., Hansen, B. F., Richter, E. A., & Kiens, B.
Affiliations: University of Copenhagen (DK)
Novo Nordisk (Denmark) (DK)
Corresponding author: Wojtaszewski, Jørgen F. P.
ORCID: Wojtaszewski, Jørgen F. P.
Richter, Erik A.
Kiens, Bente
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2000-10
Volume: 528
Issue: 1
Pages: 221-226
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1111/j.1469-7793.2000.t01-1-00221.x
PMC: PMC2270117
OpenAlex: W2140558936
Semantic Scholar: 4455ede831ee4c56d6d419343f5a067b2777281c
Cited by: 435
References: 25
Citations by year: 2026: 7 · 2025: 11 · 2024: 10 · 2023: 11 · 2022: 19 · 2021: 18 · 2020: 23 · 2019: 16 · 2018: 13 · 2017: 13 · 2016: 19 · 2015: 18 · 2014: 14 · 2013: 23 · 2012: 16
FWCI: 6.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: Sundhed og Sygdom, Det Frie Forskningsråd
Danmarks Grundforskningsfond
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: AMPK, exercise intensity, skeletal muscle metabolism, vastus lateralis, post-exercise recovery, human exercise
MeSH terms: Adult, Enzyme Activation, Exercise Test, Physical Exertion, Glycogen, Humans, Isoenzymes, Male, Multienzyme Complexes, Protein Serine-Threonine Kinases, Muscle, Skeletal, AMP-Activated Protein Kinases

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Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle

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