Cited by 230Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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beta-cell turnover: its assessment and implications.

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Bonner-Weir, S·2001·Diabetes

DOI 10.2337/diabetes.50.2007.s20

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Abstract

The pancreatic beta-cells are responsible for the maintenance of the body's glucose levels within a very narrow range; their population is dynamic and undergoes compensatory changes to maintain euglycemia. The structural parameters that allow mass changes (replication, neogenesis, cell volume changes, and cell death) can now be assessed and have proved to be powerful tools. Changes in one parameter can dramatically affect the beta-cell mass. Unfortunately, conclusions are often drawn on measurements that do not assess beta-cell mass but only relative volumes. Throughout the lifetime of a mammal, low levels of beta-cell replication and apoptosis are balanced and result in a slowly increasing mass. The balance allows gradual replacement of the beta-cell population; thus, beta-cells should be considered a slowly renewed tissue. Two major implications of beta-cell turnover are that 1) at any time, the beta-cells would be at different ages and 2) any limitation on replacement could have dire consequences for glucose homeostasis.

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Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775
Self-citation
A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development
Bonner‐Weir, S., Baxter, L. A., Schuppin, G. T., & Smith, F. E. (1993) · Diabetes · doi:10.2337/diab.42.12.1715 · Cited by 675
Self-citation
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.
Klöppel, G., Löhr, M., Habich, K., Oberholzer, M., & Heitz, P. (1985) · Survey and Synthesis of Pathology Research · doi:10.1159/000156969 · Cited by 645
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
Brüning, J. C., Winnay, J. N., Bonner‐Weir, S., Taylor, S. I., Accili, D., & Kahn, C. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81896-6 · Cited by 539
Self-citation
Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat
Scaglia, L., Cahill, C. J., Finegood, D. T., & Bonner‐Weir, S. (1997) · Endocrinology · doi:10.1210/endo.138.4.5069 · Cited by 418
Self-citation
Islet growth and development in the adult
Bonner‐Weir, S. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0240297 · Cited by 332
Self-citation
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.
Sharma, A., Zangen, D., Reitz, P., Taneja, M., Lissauer, M. E., Miller, C. P., Weir, G. C., Habener, J. F., & Bonner‐Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.3.507 · Cited by 331
Self-citation
Monoclonal Antibody to Single-Stranded DNA Is a Specific and Sensitive Cellular Marker of Apoptosis
Frankfurt, O. S., Robb, J. A., Sugarbaker, E. V., & Villa, L. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0240 · Cited by 244
Extra-insular beta cells associated with ductules are frequent in adult human pancreas
Bouwens, L., & PIPELEERS, D. G. (1998) · Diabetologia · doi:10.1007/s001250050960 · Cited by 229

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Olvera-Granados, C. P., Leo‐Amador, G. E., & Hernández-Montiel, H. L. (2008) · Boletín Médico del Hospital Infantil de México · Cited by 5
The effects of 5-aminoimidazole-4-carboxamide riboside on the pancreas in neonatal streptozotocin-diabetic rats
Öztürk, M., Bolkent, S., Dağıstanlı, F. K., Tunçdemi̇r, M., Yılmazer, S., & Akkan, A. G. (2006) · Acta Diabetologica · doi:10.1007/s00592-006-0214-6 · Cited by 5
Development of β-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat
Shimada, K., Ito, T., Tanemura, M., Komoda, H., Fumimoto, Y., Kawamoto, K., Nishida, T., Kaneto, H., & Sawa, Y. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.03.030 · Cited by 5
Regeneration of β Cells in the Native Pancreata After Syngeneic and Allogeneic Pancreas Transplantations in Spontaneously Type 2 Diabetic Torii Rats
Shimada, K., Ito, T., Miao, G., Tanemura, M., Komoda, H., Fumimoto, Y., Kawamoto, K., Nishida, T., Kaneto, H., & Sawa, Y. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.01.019 · Cited by 5
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Sparre, T., Larsen, M. R., Heding, P. E., Karlsen, A. E., Jensen, O. N., & Pociot, F. (2005) · Cited by 5
Pancreatic β‐cell turnover in health and disease
Alcibahy, Y., Darwish, R., Butler, A. E., & Moin, A. S. M. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70191 · Cited by 5
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Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes
Hanley, S. C. (2020) · McGill Journal of Medicine · doi:10.26443/mjm.v12i2.267 · Cited by 4
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Montemurro, C., Köhler, C. U., Uhl, W. H., Tannapfel, A., Schmidt, W. E., Bonora, E., & Meier, J. J. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.07.164 · Cited by 3
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Pancani, F., Lupi, R., Miccoli, R., Marchetti, P., & Prato, S. D. (2007) · International Congress Series · doi:10.1016/j.ics.2007.03.029 · Cited by 3
Detection of insulin-releasing cells using in situ immunoblotting
Chen, H., Sato, H., Totani, T., & Iwata, H. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.04.008 · Cited by 3
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Martínez, I. V., Aguilera, E. J. G., Hernando, M. E., Villares, R., & Mellado, M. (2012) · International Journal of Data Mining and Bioinformatics · doi:10.1504/ijdmb.2012.049293 · Cited by 2
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Islet transplantation for type 1 diabetes: An overview
Paty, B. W. (2005) · Paediatrics & Child Health · doi:10.1093/pch/10.1.38 · Cited by 2
Dysregulated insulin secretion is associated with pancreatic β‐cell hyperplasia and direct acinar‐β‐cell trans‐differentiation in partially eNOS ‐deficient mice
Novelli, M., Masini, M., Vecoli, C., Moscato, S., Funel, N., Pippa, A., Mattii, L., Ippolito, C., Campani, D., Neglia, D., et al. (2022) · Physiological Reports · doi:10.14814/phy2.15425 · Cited by 2
Early protein restriction increases intra-islet GLP-1 production and pancreatic β-cell proliferation mediated by the β-catenin pathway
da Rosa-Santos, C. A., Rodrigues, P. D. C., Silva, L. R., Arantes, V. C., Reis, M. A. D. B., Colodel, É. M., Damazo, A. S., de Moura, E. G., Carneiro, E. M., & Latorraca, M. Q. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02192-6 · Cited by 2
Distribution and function of glucagon-like peptide 1 (GLP-1) in the digestive tract of mammals and the clinical use of its analogues
GÓRSKA, A., & Arciszewski, M. B. (2020) · Medycyna Weterynaryjna · doi:10.21521/mw.6374 · Cited by 2
Non‐Insulin Parenteral Therapies
Holst, J. J., Madsbad, S., & Schmitz, O. (2010) · Wiley eBooks · doi:10.1002/9781444324808.ch30 · Cited by 2
Pancreatic morphology in normal and diabetic states
Hull, R. L., & Kahn, S. E. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch5 · Cited by 2
The Effects of Chronic Stress and Exercise on Mouse Pancreatic Islet of Langerhans Morphology and Muscle Atrophy Gene Expression
Parkulo, T. D. (2014) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.265 · Cited by 2
Agent-Based Model of the Endocrine Pancreas and Interaction with Innate Immune System
Martínez, I. V., Aguilera, E. J. G., Hernando, M. E., Villares, R., & Mellado, M. (2010) · Advances in intelligent and soft computing · doi:10.1007/978-3-642-13214-8_21 · Cited by 1
Differentially Expressed Proteins in the Pancreas of Diabetic Mice
Qiu, L. (2005) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Alteration of methylation pattern and gene expression of FTO, PPARγ and Slc2a4 on pre-diabetes-induced BALB/c mice
Listiyani, P., Sanjaya, R. B., Nathanael, J., Chandra, P. S., Artadana, I. B. M., & Putra, S. E. D. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05141-7 · Cited by 1
Development and maintenance of the islet β cell
Mastracci, T. L., Mirmira, R. G., & Anderson, R. M. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch4 · Cited by 1
Metabolic Syndrome, Diabetes and Nonalcoholic Steatohepatitis
Kyrou, I., Haukeland, J. W., Bhala, N. B., & Kumar, S. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch16 · Cited by 1

Authors: Bonner-Weir, S.
Affiliations: Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA. susan.bonner-weir@joslin.harvard.edu
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2001-02-01
Volume: 50
Issue: suppl_1
Pages: S20
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.50.2007.s20
OpenAlex: W2132667679
Cited by: 230
References: 26
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 7 · 2012: 14
Type: conference abstract
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: beta-cell turnover, beta-cell mass, beta-cell proliferation, beta-cell neogenesis, beta-cell apoptosis, glucose homeostasis, pancreatic islets
MeSH terms: Animals, Cell Count, Cell Division, Female, Humans, Insulin Resistance, Islets of Langerhans, Male, Rats, Zucker, Cell Death, Apoptosis, In Situ Nick-End Labeling, Models, Animal, Rats

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