Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy

Cheong, Jean N.; Cuffe, James S. M.; Jefferies, Andrew J.; Anevska, Kristina; Moritz, Karen M.; Wlodek, Mary E.

doi:10.1210/en.2016-1335

Cited by 28Birth, Development, and HealthPregnancy and preeclampsia studiesPancreatic function and diabetes

Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy

Cheong, Jean N., Cuffe, James S. M., Jefferies, Andrew J., Anevska, Kristina, Moritz, Karen M., Wlodek, Mary E.·2016·Endocrinology

DOI 10.1210/en.2016-1335

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Abstract

Low birth weight increases adult metabolic disease risk in both the first (F1) and second (F2) generation. Physiological stress during pregnancy in F1 females that were born small induces F2 fetal growth restriction, but the long-term metabolic health of these F2 offspring is unknown. Uteroplacental insufficiency (restricted) or sham (control) surgery was performed in F0 rats. F1 females (control, restricted) were allocated to unstressed or stressed pregnancies. F2 offspring exposed to maternal stress in utero had reduced birth weight. At 6 months, F2 stressed males had elevated fasting glucose. In contrast, F2 restricted males had reduced pancreatic β-cell mass. Interestingly, these metabolic deficits were not present at 12 month. F2 males had increased adrenal mRNA expression of steroidogenic acute regulatory protein and IGF-1 receptor when their mothers were born small or exposed to stress during pregnancy. Stressed control F2 males had increased expression of adrenal genes that regulate androgen signaling at 6 months, whereas expression increased in restricted male and female offspring at 12 months. F2 females from stressed mothers had lower area under the glucose curve during glucose tolerance testing at 12 months compared with unstressed females but were otherwise unaffected. If F1 mothers were either born small or exposed to stress during her pregnancy, F2 offspring had impaired physiological outcomes in a sex- and age-specific manner. Importantly, stress during pregnancy did not exacerbate disease risk in F2 offspring of mothers born small, suggesting that they independently program disease in offspring through different mechanisms.

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Adrenal, metabolic and cardio‐renal dysfunction develops after pregnancy in rats born small or stressed by physiological measurements during pregnancy
Cheong, J. N., Cuffe, J. S. M., Jefferies, A. J., Moritz, K. M., & Wlodek, M. E. (2016) · The Journal of Physiology · doi:10.1113/jp272212 · Cited by 15 · see citing works
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Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats.
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Effect of Pregnancy for Females Born Small on Later Life Metabolic Disease Risk
Tran, M., Gallo, L. A., Wadley, G. D., Jefferies, A. J., Moritz, K. M., & Wlodek, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045188 · Cited by 16 · see citing works
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Authors: Cheong, J. N., Cuffe, J. S. M., Jefferies, A. J., Anevska, K., Moritz, K. M., & Wlodek, M. E.
Affiliations: The University of Melbourne (AU)
Griffith University (AU)
The University of Queensland (AU)
Corresponding author: Wlodek, Mary E.
ORCID: Cuffe, James S. M.
Anevska, Kristina
Moritz, Karen M.
Wlodek, Mary E.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2016-08-29
Volume: 157
Issue: 11
Pages: 4104-4120
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2016-1335
OpenAlex: W2513212246
Cited by: 28
References: 89
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 2
FWCI: 6.20
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Griffith Research Online (submittedVersion)
Funders: University of Melbourne
Medical Research Council
National Health and Medical Research Council (1025426)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: prenatal stress, fetal growth restriction, low birth weight, beta-cell mass, fasting blood glucose, glucose tolerance, IGF-1 receptor, androgen signaling, placental insufficiency
MeSH terms: Age Factors, Animals, Birth Weight, Blood Glucose, Female, Fetal Growth Retardation, Glucose Tolerance Test, Insulin Resistance, Male, Maternal-Fetal Exchange, Placental Insufficiency, Pregnancy, Prenatal Exposure Delayed Effects, RNA, Messenger, Sex Factors, Stress, Physiological, Rats, Wistar, Receptor, IGF Type 1, Insulin-Secreting Cells, Rats

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Sex-Specific Metabolic Outcomes in Offspring of Female Rats Born Small or Exposed to Stress During Pregnancy

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