The efficiency of cellular energy transduction and its implications for obesity

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

Obesity and the regulation of energy balance

Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works

Mitochondrial dysfunction and type 2 diabetes

Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works

Changes in Energy Expenditure Resulting from Altered Body Weight

Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works

A role for brown adipose tissue in diet-induced thermogenesis

Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606 · see citing works

Thermogenic mechanisms in brown fat.

Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602 · see citing works

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

The Response to Long-Term Overfeeding in Identical Twins

Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278 · see citing works

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201 · see citing works

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues

Lenzen, S., Drinkgern, J., & Tiedge, M. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)02051-5 · Cited by 1,167 · see citing works

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,127 · see citing works

The Human Obesity Gene Map: The 2005 Update

Rankinen, T., Zuberi, A., Chagnon, Y. C., Weisnagel, S. J., Argyropoulos, G., Walts, B., Pérusse, L., & Bouchard, C. (2006) · Obesity · doi:10.1038/oby.2006.71 · Cited by 1,119 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves‐Guerra, M., Goubern, M., Surwit, R. S., et al. (2000) · Nature Genetics · doi:10.1038/82565 · Cited by 1,079 · see citing works

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

Brand, M. D., Affourtit, C., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Pakay, J. L., & Parker, N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.034 · Cited by 1,032 · see citing works

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Erickson, J. C., Clegg, K. E., & Palmiter, R. D. (1996) · Nature · doi:10.1038/381415a0 · Cited by 1,009 · see citing works

New drug targets for type 2 diabetes and the metabolic syndrome

Moller, D. E. (2001) · Nature · doi:10.1038/414821a · Cited by 1,009 · see citing works

A CASE OF SEVERE HYPERMETABOLISM OF NONTHYROID ORIGIN WITH A DEFECT IN THE MAINTENANCE OF MITOCHONDRIAL RESPIRATORY CONTROL: A CORRELATED CLINICAL, BIOCHEMICAL, AND MORPHOLOGICAL STUDY

Luft, R., Ikkos, D., Palmieri, G. M. A., Ernster, L., & Afzelius, B. A. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104637 · Cited by 981 · see citing works

A hierarchy of ATP-consuming processes in mammalian cells

Buttgereit, F., & Brand, M. D. (1995) · Biochemical Journal · doi:10.1042/bj3120163 · Cited by 929 · see citing works

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

Wu, M., Neilson, A., Swift, A. L., Moran, R., Tamagnine, J., Parslow, D., Armistead, S., Lemire, K., Orrell, J., Teich, J., et al. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00247.2006 · Cited by 922 · see citing works

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917 · see citing works

Type 2 Diabetes-a Matter of ß-Cell Life and Death?

Rhodes, C. J. (2005) · Science · doi:10.1126/science.1104345 · Cited by 893 · see citing works

β-Cell death during progression to diabetes

Mathis, D. J., Vence, L., & Benoist, C. O. (2001) · Nature · doi:10.1038/414792a · Cited by 884 · see citing works

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Pagotto, U., Marsicano, G., Cota, D., Lutz, B., & Pasquali, R. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0009 · Cited by 856 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

Farooqi, I. S., Yeo, G. S. H., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G. E., Cheetham, T. D., & O’Rahilly, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9397 · Cited by 801 · see citing works

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

Erickson, J. C., Hollopeter, G., & Palmiter, R. D. (1996) · Science · doi:10.1126/science.274.5293.1704 · Cited by 794 · see citing works

Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity

Wadden, T. A., Berkowitz, R. I., Womble, L. G., Sarwer, D. B., Phelan, S., Cato, R. K., Hesson, L. A., Osei, S. Y., Kaplan, R., & Stunkard, A. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050156 · Cited by 794 · see citing works

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

Brand, M. D. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00135-2 · Cited by 789 · see citing works

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works

Gut hormones and the regulation of energy homeostasis

Murphy, K. G., & Bloom, S. R. (2006) · Nature · doi:10.1038/nature05484 · Cited by 778 · see citing works

Genetics of body-weight regulation

Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 775 · see citing works

A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

Nègre‐Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Pénicaud, L., & Casteilla, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271366 · Cited by 757 · see citing works

Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740 · see citing works

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700 · see citing works

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677 · see citing works

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X.-M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1596 · Cited by 667 · see citing works

Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.

Vidal‐Puig, A., Jimenez‐Liñan, M., Lowell, B. B., Hamann, A., Hu, E., Spiegelman, B. M., Flier, J. S., & Moller, D. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118703 · Cited by 656 · see citing works

Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization

Ravussin, É., & Bogardus, C. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.5.968 · Cited by 606 · see citing works

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604 · see citing works

A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

Echtay, K. S., Esteves, T. C., Pakay, J. L., Jekabsons, M. B., Lambert, A. J., Portero‐Otín, M., Pamplona, R., Vidal‐Puig, A. J., Wang, S., Roebuck, S. J., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg412 · Cited by 597 · see citing works

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

Ravinet‐Trillou, C., Delgorge, C., Menet, C., Arnone, M., & Soubrié, P. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802583 · Cited by 583 · see citing works

How Obesity Causes Diabetes: Not a Tall Tale

Lazar, M. A. (2005) · Science · doi:10.1126/science.1104342 · Cited by 570 · see citing works

Mitochondrial function in normal and diabetic β-cells

Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519 · see citing works

Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

Hany, T. F., Gharehpapagh, E., Kamel, E. M., Buck, A., Himms-Hagen, J., & von Schulthess, G. K. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0902-6 · Cited by 511 · see citing works

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

Gimeno, R. E., Dembski, M., Weng, X., Deng, N., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Woolf, E. A., & Tartaglia, L. A. (1997) · Diabetes · doi:10.2337/diab.46.5.900 · Cited by 496 · see citing works

Targeted Disruption of the β3-Adrenergic Receptor Gene

Susulic, V. S., Frederich, R. C., Lawitts, J. A., Tozzo, E., Kahn, B. B., Harper, M., Himms‐Hagen, J., Flier, J. S., & Lowell, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29483 · Cited by 493 · see citing works

Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

Green, K., Brand, M. D., & Murphy, M. P. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s110 · Cited by 490 · see citing works

Appetite suppression and weight loss after the cannabinoid antagonist SR 141716

Colombo, G., Agabio, R., Diaz, G., Lobina, C., Reali, R., & Gessa, G. L. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00322-1 · Cited by 486 · see citing works

The causes and functions of mitochondrial proton leak

Brand, M. D., Chien, L.-F., Ainscow, E. K., Rolfe, D. F. S., & Porter, R. K. (1994) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(94)90099-x · Cited by 466 · see citing works

Gut Hormones and Appetite Control

Wren, A., & Bloom, S. R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.048 · Cited by 434 · see citing works

Medicinal strategies in the treatment of obesity

Bray, G. A., & Tartaglia, L. A. (2000) · Nature · doi:10.1038/35007544 · Cited by 432 · see citing works

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430 · see citing works

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal · doi:10.1042/bj20050890 · Cited by 410 · see citing works

The efficiency and plasticity of mitochondrial energy transduction.

Brand, M. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330897 · Cited by 406 · see citing works

Glucose Sensing in Pancreatic β-Cells

Schuit, F. C., Huypens, P., Heimberg, H., & PIPELEERS, D. G. (2001) · Diabetes · doi:10.2337/diabetes.50.1.1 · Cited by 405 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C., Scorrano, L., Dalgaard, L. T., St‐Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19774 · Cited by 401 · see citing works

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Krauss, S., Zhang, C.-Y., Scorrano, L., Dalgaard, L. T., St-Pierre, J., Grey, S. T., & Lowell, B. B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319774 · Cited by 401 · see citing works

A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line

Gribble, F. M., Williams, L., Simpson, A. K., & Reimann, F. M. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1147 · Cited by 390 · see citing works

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis

Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 388 · see citing works

Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 385 · see citing works

Neuronal Glucosensing

Levin, B. E., Routh, V. H., Kang, L., Sanders, N. M., & Dunn-Meynell, A. A. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2521 · Cited by 370 · see citing works

The CB1 receptor antagonist rimonabant reverses the diet‐induced obesity phenotype through the regulation of lipolysis and energy balance

Jbilo, O., Ravinet‐Trillou, C., Arnone, M., Buisson, I., Bribes, E., Péleraux, A., Pénarier, G., Soubrié, P., Fur, G. L., Galiègue, S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3177fje · Cited by 346 · see citing works

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets

Zhang, C., Parton, L. E., Ye, C. P., Krauss, S., Shen, R., Lin, C.-T., Porco, J. A. J., & Lowell, B. B. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.010 · Cited by 332 · see citing works

Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate

Rolfe, D. F. S., & Brand, M. D. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1380 · Cited by 330 · see citing works

Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An Hypothesis

Himms‐Hagen, J., & Harper, M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600204 · Cited by 325 · see citing works

Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lepob/Lepob mice

Liu, Y., Connoley, I. P., WILSON, C. A., & Stock, M. J. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802847 · Cited by 314 · see citing works

Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans

Tsuneki, H., Ishizuka, M., Terasawa, M., Wu, J.-B., Sasaoka, T., & Kimura, I. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-18 · Cited by 311 · see citing works

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

Samec, S., Seydoux, J., & Dulloo, A. G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.715 · Cited by 305 · see citing works

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2

Coppola, A., Liu, Z.-W., Andrews, Z. B., Paradis, E., Roy, M.-C., Friedman, J. M., Ricquier, D., Richard, D., Horvath, T. L., Gao, X.-B., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.12.002 · Cited by 295 · see citing works

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice

Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291 · see citing works

Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile

Brand, M. D., Couture, P., Else, P. L., Withers, K., & Hulbert, A. J. (1991) · Biochemical Journal · doi:10.1042/bj2750081 · Cited by 287 · see citing works

Thermogenesis in Muscle

Block, B. A. (1994) · Annual Review of Physiology · doi:10.1146/annurev.ph.56.030194.002535 · Cited by 281 · see citing works

The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint

Rorsman, P. (1997) · Diabetologia · doi:10.1007/s001250050706 · Cited by 278 · see citing works

Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR

Rolfe, D. F. S., Newman, J. M. B., Buckingham, J. A., Clark, M. G., & Brand, M. D. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.3.c692 · Cited by 277 · see citing works

The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides

Wang, R., Liu, X., Hentges, S. T., Dunn-Meynell, A. A., Levin, B. E., Wang, W., & Routh, V. H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.1959 · Cited by 267 · see citing works

The proton leak across the mitochondrial inner membrane

Brand, M. D. (1990) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(90)90232-s · Cited by 261 · see citing works

Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate

Porter, R. K., & Brand, M. D. (1993) · Nature · doi:10.1038/362628a0 · Cited by 257 · see citing works

Mitochondrial uncoupling as a target for drug development for the treatment of obesity.

Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00043.x · Cited by 250 · see citing works

Pathways to obesity

Jéquier, E. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802123 · Cited by 250 · see citing works

Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats

Ghorbani, M., & Himms‐Hagen, J. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800432 · Cited by 250 · see citing works

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan, C. B., MacDonald, P. E., Saleh, M. C., Johns, D. C., Marbàn, E., & Wheeler, M. B. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1482 · Cited by 242 · see citing works

Gluttony and thermogenesis revisited

Stock, M. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801108 · Cited by 242 · see citing works

The Physiological Significance of Mitochondrial Proton Leak in Animal Cells and Tissues

Rolfe, D. F. S., & Brand, M. D. (1997) · Bioscience Reports · doi:10.1023/a:1027327015957 · Cited by 232 · see citing works

Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring

Flier, J. S., Harris, M., & Hollenberg, A. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9725 · Cited by 230 · see citing works

Different origins and developmental histories of transient neurons in the marginal zone of the fetal and neonatal rat cortex

Meyer, G., Soria, J. M., Martinez-Galan, J. R., Mart�n-Clemente, B., & Fair�n, A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980810)397:4 · Cited by 228 · see citing works

Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus

Gerich, J. E. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.4.447 · Cited by 222 · see citing works

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220 · see citing works

Insights from the developing world: thrifty genotypes and thrifty phenotypes

Prentice, A. M., Rayco‐Solon, P., & Moore, S. E. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005421 · Cited by 215 · see citing works

Nonexercise activity thermogenesis (NEAT): environment and biology

Levine, J. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00562.2003 · Cited by 212 · see citing works

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206 · see citing works

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

Cadenas, S., Echtay, K. S., Harper, J. A., Jekabsons, M. B., Buckingham, J. A., Grau, E., Abuin, A., Chapman, H., Clapham, J. C., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109736200 · Cited by 199 · see citing works

Non-ohmic proton conductance of the mitochondrial inner membrane in hepatocytes.

Nobes, C. D., Brown, G. C., Olive, P. N., & Brand, M. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38245-6 · Cited by 191 · see citing works

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes

Wollheim, C. B. (2000) · Diabetologia · doi:10.1007/s001250050044 · Cited by 191 · see citing works

Thermogenic effects of sibutramine in humans

Hansen, D. L., Toubro, S., Stock, M. J., Macdonald, I. A., & Astrup, A. V. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1180 · Cited by 182 · see citing works

Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production

Brand, M. D., Buckingham, J. A., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Murphy, M. P., Pakay, J. L., Talbot, D. A., & Echtay, K. S. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710203 · Cited by 182 · see citing works

Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates.

Murray, H. W., & Cohn, Z. A. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.150.4.938 · Cited by 176 · see citing works

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-803 · Cited by 164 · see citing works

Association of mitochondrial function with feed efficiency within a single genetic line of male broilers

Bottje, W. G., Iqbal, M., Tang, Z., Cawthon, D. L., Okimoto, R., Wing, T. L., & Cooper, M. (2002) · Poultry Science · doi:10.1093/ps/81.4.546 · Cited by 161 · see citing works

Original Articles Sibutramine Reduces Food Intake in Non‐Dieting Women with Obesity

Rolls, B. J., Shide, D. J., Thorwart, M. L., & Ulbrecht, J. S. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00308.x · Cited by 158 · see citing works

Metabolic control of -cell function

Deeney, J. T., Prentki, M., & Corkey, B. E. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0175 · Cited by 150 · see citing works

Uncoupling the agony from ecstasy

Mills, E., Banks, M. L., Sprague, J. E., & Finkel, T. (2003) · Nature · doi:10.1038/426403a · Cited by 148 · see citing works

Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds

Brand, M. D., Turner, N. A., Ocloo, A., Else, P. L., & Hulbert, A. J. (2003) · Biochemical Journal · doi:10.1042/bj20030984 · Cited by 147 · see citing works

The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals

Young, E. H., Wareham, N. J., Farooqi, I. S., Hinney, A., Hebebrand, J., Scherag, A., O’Rahilly, S., Barroso, I., & Sandhu, M. S. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803609 · Cited by 147 · see citing works

The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3

Esteves, T. C., & Brand, M. D. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.06.002 · Cited by 146 · see citing works

Estimation of the fructose diphosphatase–phosphofructokinase substrate cycle in the flight muscle of Bombus affinis

Clark, M. G., Bloxham, D. P., Holland, P. C., et al. (1973) · Biochemical Journal · doi:10.1042/bj1340589 · Cited by 143 · see citing works

Mitochondrial uncouplers with an extraordinary dynamic range

Lou, P.-H., Hansen, B. S., Olsen, P. H., Tullin, S., Murphy, M. P., & Brand, M. D. (2007) · Biochemical Journal · doi:10.1042/bj20070606 · Cited by 141 · see citing works

In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate

Jekabsons, M. B., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401540200 · Cited by 140 · see citing works

Mitochondrial signals in glucose‐stimulated insulin secretion in the beta cell

Maechler, P., & Wollheim, C. B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00049.x · Cited by 140 · see citing works

ACTIONS AND USES OF DINITROPHENOL

Cutting, W., MEHRTENS, H. G., & Tainter, M. L. (1933) · JAMA · doi:10.1001/jama.1933.02740280013006 · Cited by 138 · see citing works

Opioids as agents of reward-related feeding: a consideration of the evidence

Levine, A. S., & Billington, C. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.032 · Cited by 138 · see citing works

Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages

Kizaki, T., Suzuki, K., Hitomi, Y., Taniguchi, N., Saitoh, D., Watanabe, K., Onoé, K., Day, N. K. B., Good, R. A., & Ohno, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142206299 · Cited by 137 · see citing works

Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adults

Bosy‐Westphal, A., Reinecke, U., Schlörke, T., Illner, K., Kutzner, D., Heller, M., & Müller, M. J. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802526 · Cited by 137 · see citing works

The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models

Ellacott, K. L. J., & Cone, R. D. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1861 · Cited by 134 · see citing works

Relationship between resting metabolic rate and the composition of the fat-free mass

Sparti, A., DeLany, J. P., de la Bretonne, J. A., Sander, G. E., & Bray, G. A. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90222-5 · Cited by 129 · see citing works

Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women

Harper, M.-E., Dent, R., Monemdjou, S., Bézaire, V., Van Wyck, L., Wells, G., Kavaslar, G. N., Gauthier, A., Tesson, F., & McPherson, R. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2459 · Cited by 129 · see citing works

Agouti-related protein-deficient mice display an age-related lean phenotype

Wortley, K. E., Anderson, K. D., Yasenchak, J., Murphy, A., Valenzuela, D., Diano, S., Yancopoulos, G. D., Wiegand, S. J., & Sleeman, M. W. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.004 · Cited by 128 · see citing works

Causes of differences in respiration rate of hepatocytes from mammals of different body mass

Porter, R. K., & Brand, M. D. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.5.r1213 · Cited by 127 · see citing works

Control of the effective P/O ratio of oxidative phosphorylation in liver mitochondria and hepatocytes

Brand, M. D., Harper, M., & Taylor, H. C. (1993) · Biochemical Journal · doi:10.1042/bj2910739 · Cited by 126 · see citing works

Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR

Woods, S. C., Seeley, R. J., & Cota, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155505 · Cited by 125 · see citing works

Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

Marcinek, D. J., Schenkman, K. A., Ciesielski, W. A., Lee, D., & Conley, K. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.097782 · Cited by 123 · see citing works

Drug Treatment of the Overweight Patient

Bray, G. A., & Ryan, D. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.053 · Cited by 115 · see citing works

USE OF DINITROPHENOL IN OBESITY AND RELATED CONDITIONS: A PROGRESS REPORT

TAINTER, M. L., STOCKTON, A. B., & CUTTING, W. C. (1933) · Journal of the American Medical Association · doi:10.1001/jama.1933.02740440032009 · Cited by 112 · see citing works

Experimental discrimination between proton leak and redox slip during mitochondrial electron transport

Brand, M. D., Chien, L., & Diolez, P. (1994) · Biochemical Journal · doi:10.1042/bj2970027 · Cited by 99 · see citing works

Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis

Gimeno, R. E., Dembski, M., Weng, X., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.5.900 · Cited by 98 · see citing works

Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo

Conley, K. E., Amara, C. E., Jubrias, S. A., & Marcinek, D. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.034330 · Cited by 96 · see citing works

CL-316,243, a β3-Specific Adrenoceptor Agonist, Enhances Insulin-Stimulated Glucose Disposal in Nonobese Rats

de Souza, C. J., Hirshman, M. F., & Horton, E. S. (1997) · Diabetes · doi:10.2337/diab.46.8.1257 · Cited by 94 · see citing works

Effects of Sibutramine on Resting Metabolic Rate and Weight Loss in Overweight Women

SEAGLE, H. M., Bessesen, D. H., & Hill, J. O. (1998) · Obesity Research · doi:10.1002/j.1550-8528.1998.tb00324.x · Cited by 89 · see citing works

Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria

HARPER, J. A., STUART, J. A., JEKABSONS, M. B., ROUSSEL, D., BRINDLE, K. M., DICKINSON, K., JONES, R. B., & BRAND, M. D. (2002) · Biochemical Journal · doi:10.1042/bj3610049 · Cited by 87 · see citing works

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

Affourtit, C., & Brand, M. D. (2008) · Biochemical Journal · doi:10.1042/bj20070954 · Cited by 85 · see citing works

Processes Contributing To Metabolic Depression In Hepatopancreas Cells From The Snail Helix Aspersa

Bishop, T., & Brand, M. D. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.23.3603 · Cited by 83 · see citing works

Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose-Stimulated Insulin Secretion in a β-Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element-Binding Protein-1c

Yamashita, T., Eto, K., Okazaki, Y., Yamashita, S., Yamauchi, T., Sekine, N., Nagai, R., Noda, M., & Kadowaki, T. (2004) · Endocrinology · doi:10.1210/en.2003-1602 · Cited by 81 · see citing works

Mitochondrial coupling in vivo in mouse skeletal muscle

Marcinek, D. J., Schenkman, K. A., Ciesielski, W. A., & Conley, K. E. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00237.2003 · Cited by 81 · see citing works

Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology

Kopecký, J., Rossmeisl, M., Hodný, Z., Syrový, I., Horáková, M., & Kolarova, P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e776 · Cited by 81 · see citing works

Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

Amo, T., Yadava, N., Oh, R. J., Nicholls, D. G., & Brand, M. D. (2008) · Gene · doi:10.1016/j.gene.2008.01.007 · Cited by 74 · see citing works

Perspective on the Central Control of Appetite

Blundell, J. E. (2006) · Obesity · doi:10.1038/oby.2006.298 · Cited by 72 · see citing works

Respiration rate of hepatocytes varies with body mass in birds

Else, P. L., Brand, M. D., Turner, N. A., & Hulbert, A. J. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.01017 · Cited by 70 · see citing works

Progress in obesity research

Westerterp, K. R. (2003) · Cited by 69 · see citing works

Proton leak in hepatocytes and liver mitochondria from archosaurs (crocodiles) and allometric relationships for ectotherms

Hulbert, A., Else, P. L., Manolis, S., & Brand, M. D. (2002) · Journal of Comparative Physiology B · doi:10.1007/s00360-002-0264-1 · Cited by 68 · see citing works

Roles of Norepinephrine, Free Fatty Acids, Thyroid Status, and Skeletal Muscle Uncoupling Protein 3 Expression in Sympathomimetic-Induced Thermogenesis

Sprague, J. E., Yang, X., Sommers, J., Gilman, T. L., & Mills, E. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107755 · Cited by 62 · see citing works

Metabolic alterations associated with the antidiabetic effect of beta 3-adrenergic receptor agonists in obese mice

ARBEENY, C. M., Meyers, D. S., Hillyer, D. E., & Bergquist, K. E. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.268.4.e678 · Cited by 51 · see citing works

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-824 · Cited by 50 · see citing works

ConA induced changes in energy metabolism of rat thymocytes

Buttgereit, F., Brand, M. D., & Müller, M. (1992) · Bioscience Reports · doi:10.1007/bf02351215 · Cited by 47 · see citing works

Mitochondrial proton conductance and H+/0 ratio are independent of electron transport rate in isolated hepatocytes

Porter, R. K., & Brand, M. D. (1995) · Biochemical Journal · doi:10.1042/bj3100379 · Cited by 41 · see citing works

Why some of us get fat and what we can do about it

Levin, B. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135434 · Cited by 39 · see citing works

Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.

Ito, M., Grujić, D., Abel, E. D., et al. (1998) · Diabetes · doi:10.2337/diabetes.47.9.1464 · Cited by 39 · see citing works

Regulation of metabolic processes in brown adipose tissue in relation to nonshivering thermogenesis

Himms‐Hagen, J. (1970) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(70)90013-0 · Cited by 38 · see citing works

Use of Top-Down Elasticity Analysis to Identify Sites of Thyroid Hormone-Induced Thermogenesis

Harper, M., & Brand, M. D. (1995) · Experimental Biology and Medicine · doi:10.3181/00379727-208-43852b · Cited by 37 · see citing works

Does Thermoregulatory Feeding Occur in Newborn Infants? A Novel View of the Role of Brown Adipose Tissue Thermo genesis in Control of Food Intake

Himms‐Hagen, J. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00162.x · Cited by 36 · see citing works

Respiration and adenine nucleotides of Baltic lamprey (Lampetra fluviatilis l.) hepatocytes during spawning migration

Savina, M. V., & Gamper, N. L. (1998) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(98)10026-3 · Cited by 30 · see citing works

ConA induced changes in energy metabolism of rat thymocytes

Buttgereit, F., Brand, M. D., & Müller, M. (1992) · Bioscience Reports · doi:10.1007/bf01121501 · Cited by 25 · see citing works

CL-316,243, a beta3-specific adrenoceptor agonist, enhances insulin-stimulated glucose disposal in nonobese rats

de Souza, C. J., Hirshman, M. F., & Horton, E. S. (1997) · Diabetes · doi:10.2337/diabetes.46.8.1257 · Cited by 12 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

Brown fat as a therapy for obesity and diabetes

Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376 · see citing works

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Tao, H., Zhang, Y., Zeng, X., Shulman, G. I., & Jin, S. (2014) · Nature Medicine · doi:10.1038/nm.3699 · Cited by 288 · see citing works

Regulation of obesity and insulin resistance by nitric oxide

Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.016 · Cited by 245 · see citing works

Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3

Mailloux, R. J., Seifert, E. L., Bouillaud, F., Aguer, C., Collins, S., & Harper, M.-E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.240242 · Cited by 174 · see citing works

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

Christoffersen, B. Ø., Sanchez‐Delgado, G., John, L. M., Ryan, D. H., Raun, K., & Ravussin, E. (2022) · Obesity · doi:10.1002/oby.23374 · Cited by 142 · see citing works

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Alexopoulos, S. J., Chen, S.-Y., Brandon, A. E., Salamoun, J. M., Byrne, F. L., Garcia, C. J., Beretta, M., Olzomer, E. M., Shah, D. P., Philp, A. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16298-2 · Cited by 137 · see citing works

Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle

Cavaliere, G., Trinchese, G., Bergamo, P., De Filippo, C., Mattace Raso, G., Gifuni, G., Putti, R., Moni, B. H., Canani, R. B., Meli, R., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149033 · Cited by 87 · see citing works

Mitochondrial involvement in skeletal muscle insulin resistance: A case of imbalanced bioenergetics

Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.07.008 · Cited by 67 · see citing works

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

Fu, Y.-Y., Zhang, M., Turner, N., Zhang, L.-N., Dong, T.-C., Gu, M., Leslie, S. J., Li, J.-Y., Nan, F.-J., & Li, J. (2013) · Diabetologia · doi:10.1007/s00125-013-2987-9 · Cited by 35 · see citing works

Targeting skeletal muscle mitochondrial health in obesity

Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21 · see citing works

The bioenergetics of cancer: Is glycolysis the main ATP supplier in all tumor cells?

Moreno‐Sánchez, R., Rodríguez‐Enríquez, S., Saavedra, E., Marín‐Hernández, Á., & Gallardo‐Pérez, J. C. (2009) · BioFactors · doi:10.1002/biof.31 · Cited by 128 · see citing works

A high-resolution method for assessing cellular oxidative phosphorylation efficiency: bringing mitochondrial bioenergetics into focus. Focus on “Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers”

Stary, C. M. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00203.2016 · Cited by 5 · see citing works

Bioenergetic studies of mitochondrial oxidative phosphorylation using 31phosphorus NMR.

Gyulai, L., Roth, Z., Leigh, J. S., et al. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89214-6 · Cited by 128 · see citing works

Increased mitochondrial energy efficiency in skeletal muscle after long-term fasting. Its relevance to animal performance

Bourguignon, A., Rameau, A., Toullec, G., Romestaing, C., & Roussel, D. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.159087 · Cited by 38 · see citing works

[On the reversibility of oxidative phosphorylation. II. Effect of adenosine triphosphate on the respiratory chain of respiring mitochondria].

Klingenberg, M., & Schollmeyer, P. J. (1961) · PubMed · Cited by 6 · see citing works