Cited by 883Adipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and InteractionsMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Interleukin-6 induces cellular insulin resistance in hepatocytes.

Open access

Senn, Joseph J., Klover, Peter J., Nowak, Irena A., Mooney, Robert A.·2002·Diabetes

DOI 10.2337/diabetes.51.12.3391

Open this paper in CoChat — free account Open PDF

Abstract

Interleukin (IL)-6 is one of several proinflammatory cytokines that have been associated with insulin resistance and type 2 diabetes. A two- to threefold elevation of circulating IL-6 has been observed in these conditions. Nonetheless, little evidence supports a direct role for IL-6 in mediating insulin resistance. Here, we present data that IL-6 can inhibit insulin receptor (IR) signal transduction and insulin action in both primary mouse hepatocytes and the human hepatocarcinoma cell line, HepG2. This inhibition depends on duration of IL-6 exposure, with a maximum effect at 1-1.5 h of pretreatment with IL-6 in both HepG2 cells and primary hepatocytes. The IL-6 effect is characterized by a decreased tyrosine phosphorylation of IR substrate (IRS)-1 and decreased association of the p85 subunit of phosphatidylinositol 3-kinase with IRS-1 in response to physiologic insulin levels. In addition, insulin-dependent activation of Akt, important in mediating insulin's downstream metabolic actions, is markedly inhibited by IL-6 treatment. Finally, a 1.5-h preincubation of primary hepatocytes with IL-6 inhibits insulin-induced glycogen synthesis by 75%. These data suggest that IL-6 plays a direct role in insulin resistance at the cellular level in both primary hepatocytes and HepG2 cell lines and may contribute to insulin resistance and type 2 diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.2337/diabetes.51.12.3391

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,032
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246

Show all 51 references

Sorted by citations

Items 701–800 of 879

Inflammation métabolique et insulino-résistance : Les connaissances actuelles
Dali‐Youcef, N. (2015) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(15)30075-4 · Cited by 3
The IGF-IGFBP system in aerobic exercise : with focus on skeletal muscle
Berg, U. (2007) · Figshare · Cited by 1
Role of Inflammation in the Pathogenesis of Insulin Resistance in Obesity: Specific Role of Reactive Oxygen and Reactive Nitrogen Species
Issa, N. G. (2016) · Cited by 2
Oligonol Attenuates Diabetes-Induced Pancreatic Damage by Inhibiting Inflammatory Responses via Oxidative Stress-Dependent MAPK/NF-kB SignalingPreprint
Park, C. H., Lee, J. Y., Shin, S. H., Kim, M. Y., Lee, E. S., Shin, Y. S., Kim, Y. O., Lee, S., Choi, J. S., & Yokozawa, T. (2017) · Preprints.org · doi:10.20944/preprints201705.0208.v1 · Cited by 2
“Furthermore, some studies have shown that TNF-α and IL-6 are positively correlated with measures of insulin resistance and/or plasma insulin concentration [35,36].”
Background
Thyroid Dysfunction and Cardiovascular Disease in Chronic Kidney Disease
Zoccali, C., & Mallamaci, F. (2020) · Springer eBooks · doi:10.1007/978-3-030-36871-5_24 · Cited by 1
Risk stratification and predictive value of glucose variability for the development of post-acute pancreatitis diabetes mellitus
Qian, S., Liu, Y., Wang, W., Ni, W.-J., Zhao, S., Xu, Y., Gu, P., Yu, W., & Tong, Z. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1501530 · Cited by 2
Astragaloside IV alleviates chronic low-grade inflammation in polycystic ovary syndrome by acting on IL-6R and inhibiting the NLRP3 inflammasome
Shi, H., Liu, Q., Zhong, L., Zhou, M., Zhang, T., & Lei, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-47165-7 · Cited by 1
Pediococcus acidilactici XZ106 ameliorates hyperglycemia in mice via steroid hormone and AMP-activated protein kinase pathway modulation
Zhou, S., Hu, W., Kan, J., Zalán, Z., Chengjun, J., & Du, M. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108974 · Cited by 1
Le tissue adipeux: Son rôle dans les maladies métaboliques
Pégorier, J. P. (2007) · Springer eBooks · doi:10.1007/978-2-287-33475-7_25 · Cited by 1
Mood Disorders and Cardiovascular Disease
Jennifer, L., Lavoie, K., Arsenault, A., Ditto, B., & Simon, L. S. (2012) · InTech eBooks · doi:10.5772/33278 · Cited by 1
“Adipokines also contribute to obesity-induced insulin resistance by inhibiting insulin’s signal to fat and muscle cells to absorb glucose (Senn et al., 2002; Uysal et al., 1997).”
Background
Nowe adipokiny - korzystne czy niekorzystne w aspekcie patogenezy insulinooporności?
Olszanecka‐Glinianowicz, M., Kocełak, P., Orlik, B., Handzlik, G., & Juszczyk, Ł. (2009) · Via Medica Journals · Cited by 1
Adipokines in Health and Disease
Ahima, R. S., & Goncalves, M. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_4 · Cited by 1
Effects of synbiotic Gaz consumption on insulin function and serum hs-CRP in pregnant women
Bahmani, F., Asemi, Z., Taghizadeh, M., Khassaf, A., & Alizadeh, S. (2014) · The Journal of Qazvin University of Medical Sciences · Cited by 1
Relationships between serum zinc concentrations and inflammatory intermediate factors, blood glucose, and HbA1c in postmenopausal diabetic women
Taghdir, M., Djazayeri, A., Sepandi, M., Ashourpour, M., Fariba, F., & Djalali, M. (2011) · Journal of Diabetes & Metabolic Disorders · Cited by 1
Preliminary study of the level of visfatin and the relationship with insulin resistance in Chinese patients with chronic hepatitis C.
Wang, Y., Chen, J., Pan, J., Zhang, W., Chen, Z., & Yu, F. (2013) · PubMed · Cited by 1
Exercise ameliorates diabetes-induced osteoarthritis in rats
El-Karib, A. O. (2014) · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology · doi:10.21608/eajbsc.2014.16035 · Cited by 1
“…that exercise suppresses the release of the proinflammatory cytokine, IL-6 that is known to be involved in the pathology of diabetes (Suthem et al. 1990; Senn et al. 2002) and OA (Doss et al. 2007; Stannus et al. 2010), we measured, by ELISA, the blood level of IL-6, 8 weeks after T1DM induction.”
Background
Pathomechanism of insulin resistance in chronic hepatitis C
Kukla, M., Sawczyn, T., Żwirska-Korczala, K., & Jarosz, M. J. (2011) · Gastroenterology Review · doi:10.5114/pg.2011.25376 · Cited by 1
“Przewlekła ekspozycja na zwiększone stężenie IL-6 zmniejsza autofosforylację receptorów insulinowych oraz fosforylację IRS-1 i IRS-2, co przekłada się na wzrost IR [45, 46].”
Biological role of tumor necrosis factor type α in physiology and pathophysiology
Badowska-Kozakiewicz, A. M. (2013) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2013.35071 · Cited by 1
Insulin Pathway
Kim, M., & Wands, J. R. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_15 · Cited by 1
Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases
Ren, J., Wang, X., Nakao, T., Libby, P., & Shi, G. (2023) · Cardiology Discovery · doi:10.1097/cd9.0000000000000096 · Cited by 1
Exploring the Function of Inflammatory Routes in Insulin Resistance: Interpreting the Inflammatory Veil of Medusa
Kumari, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005568 · Cited by 1
Neuroendocrine mechanisms of behavioral changes induced by hypoglycemia
Park, M. J. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1
The influence of acute resistive exercise on inflammatory markers in the blood of obese, postmenopausal women
Patrizi, R. M. (2008) · University Microfilms International eBooks · Cited by 1
Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats
Zhou, Y., Xu, J. C., & Xu, C. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15027596 · Cited by 1
“IL-6 is one of several proinflammatory cytokines that have been associated with insulin resistance (Senn et al., 2002).”
Background
Leukocyte Count as Chronic Inflammation Markers in Type 2 Diabetes Patients
Durmuş, E., Aypak, C., & Görpelioğlu, S. (2017) · Ankara Medical Journal · doi:10.17098/amj.364164 · Cited by 1
Comparing the prevalence of metabolic syndrome in systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis: A cross sectional study
Mobini, M., Niksolat, F., Mohammadpour, R. A., Sadr, S., & Dargahloo, S. D. (2018) · Rheumatology Research · doi:10.22631/rr.2018.69997.1044 · Cited by 1
“hyperglycemia, compensatory hyperinsulinemia, and dyslipidemia [22,23].”
Assessment of NF-κB-SN50’s Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression
Dahman, L. S. B., Al‐Daghri, N. M., Alfadda, A. A., Sallam, R. M., & McTernan, P. G. (2020) · doi:10.3390/iecbm2020-08579 · Cited by 1
Minor allele of rs12976445 polymorphism in the promoter region of microRNA-125a is associated with the severity of primary open-angle glaucoma (POAG)
Zhang, W., Li, Y., Ke, H.-Q., Wang, Y., Duan, C., Zhu, Q., & Liu, H. (2021) · Archives of Medical Science · doi:10.5114/aoms/135595 · Cited by 1
Relación entre Porphyromonas gingivalis y diabetes mellitus tipo 2: revisión sistemática exploratoria
Trocha–Mendoza, M. J., & Arévalo‐Caro, C. (2021) · Acta Odontológica Colombiana · doi:10.15446/aoc.v11n2.95219 · Cited by 1
“En primer lugar, porque niveles elevados de IL-6 se han relacionado con IR y por ende con DM2 (25), y en segundo lugar, porque el TNF-α puede alterar la vía de señalización de insulina y, también, interferir en la secreción de insulina por parte de las células beta pancreáticas (9).”
Background
Inflammation in chronic kidney disease
Carrero, J. J., Kistler, B. M., & Stenvinkel, P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818540-7.00049-5 · Cited by 1
Metabolic syndrome in autoimmunity.Epidemiological cross-sectional analysis of a complex interaction in a Latin American population
Universidad Autónoma de Bucaramanga, B., Blanco, E., León, J. S. T., Universidad Autónoma de Bucaramanga, B., Ayala, J. A. G., Universidad Autónoma de Bucaramanga, B., Peña, V. C., Universidad Autónoma de Bucaramanga, B., Strauch, R. G. P., Universidad Autónoma de Bucaramanga, B., et al. (2023) · Revista Salud y Desarrollo · doi:10.55717/dufq2969 · Cited by 1
“55717/DUFQ2969 insulin receptor autophosphorylation, and disrupt signaling pathways leading to hyperglycemia, compensatory hyperinsulinemia, and dyslipidemia (Senn et al., 2002; Gupta et al., 2007).”
Background
Role of calcium-independent phospholipase A2 in insulin-stimulated glucose uptake in 3T3-L1 adipocytes
Yang, J. (2009) · Cited by 1
Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome
Smith, U., & Yang, X. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch14 · Cited by 1
Type 2 diabetes exacerbates bone loss in Native American women
Leyva, M. J. (2012) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · Cited by 1
Obesità addominale e diabete
Bonora, E., Brangani, C., & Pichiri, I. (2008) · Giornale italiano di cardiologia · doi:10.1714/669.7812 · Cited by 1
The association between C-572G polymorphism of the Interleukin 6 gene promoter and type 2 diabetes mellitus in a Chinese Han population
Wang, Y., Ling-fang, K., Wang, Y., Cao, Y., & Song, Y. (2011) · International Journal of the Physical Sciences · doi:10.5897/ijps11.035 · Cited by 1
Excretion of urinary proteins as predictors of early posttransplantation complications and late renal allograft failure
Teppo, A. (2005) · Työväentutkimus Vuosikirja · Cited by 1
For Debate Interleukin-6 and insulin sensitivity: friend or foe?
Carey, A. L., & Febbraio, M. A. (2004) · Cited by 1
Altered bone cell biology associated with Type Two Diabetes Mellitus – consequences for periodontal disease
Al-Qarakhli, A. M. A. (2018) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1
Correspondence on ‘Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis‘
Ruscitti, P., Sesti, G., Cipriani, P., Gerli, R., & Giacomelli, R. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-220047 · Cited by 1
Protein and mRNA Studies of Rat FA1/Pref-1/dlk
Hedlund, G. P. (2007) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Assessment of NF-κB Inhibitor (SN50) Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and ExpressionPreprint
Al‐Daghri, N. M., Alfadda, A. A., Sallam, R. M., McTernan, P. G., & Dahman, L. S. B. (2021) · Preprints.org · doi:10.20944/preprints202104.0170.v1 · Cited by 1
Insulin Pathway
Kim, M., & Wands, J. R. (2005) · Springer eBooks · doi:10.1007/3-540-27194-5_9 · Cited by 1
COVID-19 and metabolic disorders: focus on the implicated molecular pathwaysPreprint
Nigro, E., Perrotta, F., Polito, R., D’Agnano, V., Scialò, F., Bianco, A., & Daniele, A. (2020) · doi:10.22541/au.158880240.00304700
Vitamin D, Inflammation, and Relations to Insulin Resistance in Morbidly Obese Pre-Menopausal Women
Nguyen, V. T. (2013) · Figshare
MOLECULAR MECHANISMS OF INSULIN RESISTANCE IN HUMAN SKELETAL MUSCLE AND LIPODYSTROPHIC ADIPOSE TISSUE
Korsheninnikova, E. (2003) · Työväentutkimus Vuosikirja
Association between immune reactivity and disease status of type 1, type 2 diabetes and latent autoimmune diabetes in adults
Pham, R. N., & Do, T. M. N. (2011) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
Efeito do exercício físico aeróbico agudo e crônico nos níveis séricos de citocinas e na expressão gênica em leucócitos circulantes de pacientes com lúpus eritematoso sistêmico
Perandini, L. A. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-23102014-144752
Regulation of human adipose tissue gene expression in relation to obesity and insulin resistance
Klimčáková, E. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique)
Molecular mechanisms regulating glucose uptake into podocytes: The roles of ezrin, septin 7 and nonmuscle myosin IIA
Wasik, A. A. (2014)
Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming
Glund, S. (2007) · Figshare
Fish oil and omega3 in the prevention of metabolic disorders linked to obesity: role of mitochondrial function
Pignalosa, A. (2011) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8988
Célula muscular esquelética resistente à insulina apresenta resposta alterada à IL-6 no metabolismo de carboidrato, mas não no de lipídio.
Guimarães, D. E. D. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2012.tde-24072012-165034
Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes
Lundgren, M. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Resistencia a insulina en el músculo esquelético: conexión con la obesidad
Vázquez, I. N., Fernández‐Veledo, S., García‐Guerra, L., Vila‐Bedmar, R., & Lorenzo, M. (2008) · Anales de la Real Academia Nacional de Farmacia
Fatty acid metabolism, impaired glucose tolerance and the effects of lifestyle
Corpeleijn, E. (2006) · Research Publications (Maastricht University) · doi:10.26481/dis.20061110ec
Exploratory pathway analysis
Kelder, T. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20110708tk
Resistencia a la insulina y su correlación con interleucina-6 (IL-6) en niños y adolescentes de San Luis Potosí (México)
Goldaracena-Azuara, M., Calderón, J., Mendoza, E. D. L. C., Morales, J. M. V., Mondragón-González, R., Cruz, M., Lucina, T.-R. M., & Aradillas-García, C. (2008) · RESPYN Revista de Salud Pública y Nutrición
Molecular mechanisms of insulin resistance in chronic liver disease
Bernsmeier, C. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004634719
“Upregulation of the cytokines IL-6 (136, 143) and TNF (121, 137) in response to viral infection have also been proposed to interfere with the insulin signaling cascade and initiate insulin resistance development.”
Background
Bariatric surgery and its effect on the metabolic and inflammatory aspects of morbid obesity
Nijhuis, J. (2008) · Research Publications (Maastricht University) · doi:10.26481/dis.20080625jn
Insulin resistance, genetic variation and cytokines; associations to myocardial infarction risk
Bennet, A. M. (2003) · Figshare
Novel risk markers in the chronic kidney disease patient : New insights into the wasting-inflammation axis
Carrero, J. J. (2008) · Figshare
Molecular mechanisms of insulin resistance in glucagon-producing alpha cells
Aguirre, M. G. (2006) · doi:10.53846/goediss-1294
The insulin-like growth factor system : Effects of circulating proteases
Gustafsson, S. (2005) · Figshare
PPAR β/δ, inflamació i resistència a la insulina en adipòcits
Marco, L. S. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Short Report: Association of IL-15 with Peripheral and Hepatic Insulin Sensitivity in Healthy Middle-Aged Men
Nishida, Y., Tokuyama, K., Nagasaka, S., Kiyonaga, A., Higaki, Y., Hara, M., Tanaka, K., & Tanaka, H. (2014) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2014.43007
La activación de receptor activado por proliferadores peroxisómicos β/δ mejora la resistencia a insulina inducida por IL-6 en células hepáticas
Serrano, L., Michalik, L., Wahli, W., & Vázquez‐Carrera, M. (2012) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2012.09.010
El ácido palmítico estimula la producción de interleucina 6 en células musculares esqueléticas por activación de la proteincinasa C y el factor nuclear κB
Jové, M., Planavila, A., & Vázquez‐Carrera, M. (2005) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(05)73353-2 · Cited by 1
Hepatocyte growth factor regulates inflammatory mediated diseases by suppression of IL-6: implications for type 2 diabetes
Coudriet, G. M. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
STAT-3 and the liver: A new STATion on our way to understand diabetes?
Kortylewski, M., & Barthel, A. (2004) · Hepatology · doi:10.1002/hep.1840400432
Role of interleukin-6 in states of metabolic health and disease
Holmes, A. G. (2010) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27354477
Innate immune system and adiponectin in diabetic nephropathy in type 1 diabetes
Saraheimo, M. (2009) · Työväentutkimus Vuosikirja
On the genetic variation of interleukin-6 in health and coronary heart disease
Bennermo, M. B. (2005) · Figshare
Estrogen and liver X receptors in human disease
Nilsson, M. (2006) · Figshare
Pathogenesis and treatment of lipodystrophy in hiv-infected patients receiving highly active antiretroviral therapy
Sutinen, J. (2003) · Työväentutkimus Vuosikirja
The Effect of Manipulating the IL-6 Response to Exercise on Biomarkers and Exercise Performance
Walshe, I. H. (2012) · Northumbria Research Link (Northumbria University)
Lipid Microdomains in Insulin Receptor Signalling
Vainio, S. (2006) · Työväentutkimus Vuosikirja
Análisis en animales transgénicos del papel del incremento en la gliceroneogénesis o en la captación de glucosa por el tejido adiposo
Forero, M., & Antonio, S. (2006) · TDX (Tesis Doctorals en Xarxa)
The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
Boyle, J. G. (2009) · Enlighten: Theses (The University of Glasgow)
Apical Periodontitis, inflammation and insulin resistance
(2015) · Inflammation and Cell Signaling · doi:10.14800/ics.1055
“Studies show that IL-6 reduces hepatic glycogen synthesis stimulated by insulin [45, 46] and decreases the transcription of IRS-1 and GLUT4 in adipocytes, reducing glucose uptake in adipose tissue ([47]).”
Background
SILDENAFIL ALLEVIATES INSULIN SENSITIVITY VIA ATTENUATING OXIDATIVE STRESS AND PROINFLAMMATORY CYTOKINE PRODUCTION IN DIABETIC RATS
Aboryag, N. B., Mahmoud, A. M., & Ramadan, S. A. (2013)
Serum Levels of Interlukin-6, C-Reactive Protein in Diabetic Patients and Their Relation To Progression of Diabetic Retinopathy
Ahmed, H. M., Frhood, Q. K., & Alsahlawi, M. M. R. (2014) · Medical Journal of Babylon
Editorial Body shape, insulin resistance and inflammation: bridging diabetology and cardiology?
Després, J., Barter, P. J., & Sydney, A. (2010)
SENSITIVITY AND GLUCOSE HOMEOSTASIS HAVE A BENEFICIAL ROLE IN INSULIN COUNTERPOINT: INTERLEUKIN-6 DOES NOT
Barrett, T., Kim, J. K., Davis, R. J., Sabio, G., Zhang, Z., Jun, J. Y., Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., et al. (2015)
A Síndrome Metabólica na Esquizofrenia: Uma Revisão Não Sistemática Metabolic Syndrome in Schizophrenia: A Non ‑systematic Review
Nascimento, M., & Ribeiro, R. (2012)
Angiotensinogen Gene Silencing Reduces Lipid Accumulation and Inflammation in Cultured 3T3-L1 Adipocytes
Carroll, W. X. (2012)
Bone Marrow Stem Cells and Bone Turnover in Diabetic Disease
McCabe, L. R., Raehtz, S., VanGelderen, C., & Rios‐Arce, N. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-16402-1_8
Baicalin Improves the IL-6-Mediated Hepatic Insulin Resistance in Hepa-1c1c7 Cells
Chae, B.-S., & Chanho, O. (2013) · Natural Product Sciences
Oxidative Stress in Chronic Renal Failure: Molecular Basis of Its Deleterious Effects and Therapeutical Considerations
Selvaraj, N. (2008) · INFLIBNET
Mutação inativadora do TLR4 protege contra a obesidade e a restencia a insulina induzidas por dieta hiperlipidica
Tsukumo, D. M. L. (2008) · doi:10.47749/t/unicamp.2008.424541
Studies on the possible mechanisms behind the anti-diabetic effects of Xylitol.
Chukwuma, C. I. (2013) · ResearchSpace (University of KwaZulu-Natal)
Activation of opioid μ-receptors by loperamide to improve
Shien, P. T., Cheng, J., & City, T. (2005)
Avaliação do perfil de expressão gênica modulado pelo GQ-16 em adipócitos 3T3-L1 utilizando a técnica de microarranjo
Milton, F. A. (2015) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2015.02.t.18077
Early Puberty: The Interplay among Obesity, Hormones, the Brain, and the Environment
Pope, S., & Lytle, S. (2015) · Child and Adolescent Psychopharmacology News · doi:10.1521/capn.2015.20.6.1
Der Einfluss erhöhter Glukosekonzentrationen auf die Produktion von Interleukin-6 in vivo und in vitro
Roden, M. (2011)
Identification and functional studies of two novel serine phosphorylation sites of insulin receptor substrate (IRS)-2: Ser 675 and Ser 907
Naturwissenschaften, F. (2010)
Glycerol -3 -phosphate acyltransferase isoforms: Hepatic triacylglycerol synthesis and the development of insulin resistance
Nagle, C. A. (2007)
Monocyte-macrophage dialogue with adipocytes : implication in human obesity-related type 2 diabetes
Hruskova, Z. (2016) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/65905
“In particular, IL6 expression by adipocytes has been considered to be one of the key inflammatory cytokines that promote insulin resistance (Kern et al., 2001; Rotter et al., 2003; Senn et al., 2002).”
Background
PGC-1 alfa como regulador inflamatório na esteato-hepatite não-alcoólica
Barroso, W. A. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2016.tde-06062016-125337
AVALIAÇÃO DA ANEXINA A1, IL-6 E DE VIAS SINALIZADORAS INTRACELULARES NA OBESIDADE E NO DIABETES MELLITUS TIPO 2
Pós-Graduação, P. D. (2013)

Authors: Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A.
Affiliations: University of Rochester Medicine (US)
ORCID: Mooney, Robert A.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-12-01
Volume: 51
Issue: 12
Pages: 3391-3399
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.12.3391
OpenAlex: W2130078845
Cited by: 883
References: 51
Citations by year: 2026: 27 · 2025: 19 · 2024: 22 · 2023: 29 · 2022: 28 · 2021: 41 · 2020: 42 · 2019: 31 · 2018: 31 · 2017: 36 · 2016: 49 · 2015: 46 · 2014: 46 · 2013: 34 · 2012: 39
FWCI: 23.00
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Funders: Centers for Disease Control and Prevention (PHS R01 38138)
U.S. Public Health Service
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: interleukin-6, insulin resistance, hepatocytes, insulin receptor signaling, IRS-1 tyrosine phosphorylation, phosphatidylinositol 3-kinase, p85 regulatory subunit, Akt activation, glycogen synthesis, type 2 diabetes, inflammatory cytokines
MeSH terms: Animals, Cell Line, Dose-Response Relationship, Drug, Humans, Insulin, Insulin Resistance, Phosphoproteins, Phosphorylation, Proto-Oncogene Proteins, Receptor, Insulin, Time Factors, Tyrosine, Signal Transduction, Interleukin-6, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Hepatocytes, Proto-Oncogene Proteins c-akt, Mice, Insulin Receptor Substrate Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Interleukin-6 induces cellular insulin resistance in hepatocytes.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks