Cited by 837Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismHormonal and reproductive studies

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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Nishizawa, Hitoshi, Shimomura, Iichiro, Kishida, Ken, Maeda, Norikazu, Kuriyama, Hiroshi, Nagaretani, Hiroyuki, Matsuda, Morihiro, Kondo, Hidehiko, Furuyama, Naoki, Kihara, Shinji, Nakamura, Tadashi, Tochino, Yoshihiro, Funahashi, Tohru, Matsuzawa, Yuji·2002·Diabetes

DOI 10.2337/diabetes.51.9.2734

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Abstract

Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 ± 11.9 years [mean ± SD]) than in 137 women (53.2 ± 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.

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Oxidative Stress Associated with Rapid Weight Reduction Decreases Circulating Adiponectin Concentrations
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Dearborn, J. L., Schneider, A. L. C., Gottesman, R. F., Kurth, T., Pankow, J. S., Couper, D. J., Rose, K. M., Williams, M. A., & Peterlin, B. L. (2014) · Neurology · doi:10.1212/wnl.0000000000001067 · Cited by 26
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“Sex-based differences in adiponectin levels have also been reported, and it has been hypothesized that androgens inhibit secretion of adiponectin, resulting in lower levels of adiponectin in men.(37) Furthermore, sex-based differences in fat distribution may play a role in pathophysiology of leptin and adiponectin sec…”
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Authors: Nishizawa, H., Shimomura, I., Kishida, K., Maeda, N., Kuriyama, H., Nagaretani, H., Matsuda, M., Kondo, H., Furuyama, N., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T., & Matsuzawa, Y.
Affiliations: The University of Osaka (JP)
From the Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
ORCID: Nishizawa, Hitoshi
Shimomura, Iichiro
Kishida, Ken
Maeda, Norikazu
Kihara, Shinji
Nakamura, Tadashi
Tochino, Yoshihiro
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2002-09-01
Volume: 51
Issue: 9
Pages: 2734-2741
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.51.9.2734
OpenAlex: W2102610155
Cited by: 837
References: 44
Citations by year: 2026: 13 · 2025: 18 · 2024: 7 · 2023: 32 · 2022: 19 · 2021: 28 · 2020: 25 · 2019: 32 · 2018: 34 · 2017: 24 · 2016: 21 · 2015: 41 · 2014: 46 · 2013: 43 · 2012: 51
FWCI: 28.65
Type: journal article
Language: en
Open access: closed
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: adiponectin, androgens, testosterone, sex hormones, insulin sensitivity, insulin resistance, atherosclerosis, hypoadiponectinemia, ovariectomy, castration, adipocytes, 3T3-L1 adipocytes, sex differences, menopause
MeSH terms: Adult, Androgens, Animals, Female, Humans, Insulin, Male, Mice, Inbred C57BL, Mice, Inbred ICR, Middle Aged, Ovariectomy, Proteins, Sex Characteristics, Testosterone, 3T3 Cells, Adipocytes, Postmenopause, Intercellular Signaling Peptides and Proteins, Mice, Adiponectin

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Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

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